Global ETD Search
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Showing 1 to 7 of 7 for “"CYP2J2"”.
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Protein-protein interactions and mechanistic insights for CYP2J2 and CYP5A1
… from the oxidation of -3 and -6 fatty acids. CYP2J2 and CYP5A1 are two key enzymes involved in the formation of eicosanoids. CYP2J2 is a classical P450 which requires transfer of electrons from its obligate redox partner, cytochrome P450 reductase (CPR). Here the triphasic kinetics of the …
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Enzymology of lipid metabolism by CYP2J2 as controlled by multiple-ligand binding events
… the predominant CYP epoxygenase in the heart, CYP2J2. We aim to understand how multiple-ligand binding events effect the endogenous lipid metabolism by CYP2J2 in order to understand how they may effect cardiovascular and cerebrovascular function. We have developed a combined approach of kinetic …
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Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
Cytochrome P450 2J2 (CYP2J2) is membrane bound enzyme that is highly expressed in the cardiovascular system and brain where it mediates the metabolism of polyunsaturated fatty acids into oxygenated bioactive metabolites. This enzyme is most well-known for the conversion of arachidonic acid into …
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From macromolecular crowding to transcriptional regulation: Exploring the complexities of cytochrome P450s, cannabinoids, and inflammation
… interactions of the Cytochrome P450 2J2 (CYP2J2) and its redox partner Cytochrome P450 Reductase (CPR). CYP2J2 is a membrane-bound epoxygenase expressed in cardiac tissue that is known to metabolize fatty acids as well as several xenobiotics. Previous studies on the effects of …
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
… genes. Results showed that CYP1B1, CYP2D6, CYP2J2, CYP2R1, CYP2U1 and CYP4X1 mRNA were present in all cell lines. The study also showed that CYP2A6, CYP2C8, CYP2C18, CYP2F1 and CYP4Z1 mRNA were expressed in certain BCCs that were characterised by oestrogen receptor (ER) - ER-positive …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… lipid mediators. Recently, CYP450 2J2 (CYP2J2) was found to metabolize EPEA to epoxyeicosatetraenoic-ethanolamide (EEQ-EAs) and DHEA to epoxydocosapentaenoic-ethanolamide (EDP-EAs) that are known as omega-3 eCB epoxides. Previously, 17,18-EEQ-EA and 19,20-EDP-EA have shown to have …
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Theoretical and computational investigations of membrane associated molecular pathology
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms