Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"CYP2D6"”.
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CYP2D6 Inhibitory Activities of Sarpogrelate hydrochloride and Drug-Drug Interaction
… Nine healthy male subjects genotyped for CYP2D6*1/*1 or *1/*2 were included in a randomized, open-label, three-treatment three-period, crossover study. A single oral dose of metoprolol (100 mg) was administered with water (treatment A) and sarpogrelate (100 mg bid.; a total dose of 200 mg; …
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Post-mortem Molecular Investigation: exploring genetic variation in CYP2D6 in deceased individuals at Salt River Mortuary
… assay to sequence the drug metabolising enzyme, CYP2D6. Subsequent to primer design, exons in CYP2D6 were amplified and sequenced. The optimised assay was then applied to DNA from two decedents suspected to have demised from drug intoxication. Following a toxicological drug screen, certain drugs …
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Microarray and molecular genetic analysis of aberrant splicing in human drug metabolizing cytochromes P450 CYP2D6 and CYP2B6
… chosen based on 5 different probes. Within the CYP2D6 gene it was known that the SNP 2988G>A (allele *41) in intron 6 shifts splicing towards a variant lacking exon 6, what explains the intermediate phenotype within allele *41. The splicing platform verified this splicing aberration in allele …
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Fenotipos metabólicos de CYP2D6 relacionados a efectos adversos y falla terapéutica en pacientes colombianos tratados con tramadol
… un profármaco que requiere ser metabolizado por CYP2D6, para generar su metabolito activo O-Desmetiltramadol el cual actúa sobre los receptores miu y de esta forma cumple gran parte de su acción analgésica. Este fármaco se ha visto implicado en diversos efectos adversos y falla terapéutica a …
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CYP2D in the Brain Alters Response to Drugs and Neurotoxins
… acting drugs and neurotoxins. In humans, CYP2D6 is genetically polymorphic, resulting in variable activity. CYP2D in the liver is regulated primarily by genetics, while CYP2D in the brain is affected by genetics and other factors, including xenobiotic induction and hormonal regulation. …
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A Double-blinded Randomized Controlled Trial on the Effect of Distant Reiki on Pain after Non-emergency Caesarean Section and the Effect of CYP2D6 Variation on Codeine Analgesia
… into morphine by the Cytochrome P450 enzyme 2D6 (CYP2D6). Individuals who convert up to 50 fold more codeine into morphine, ultrarapid metaboizers, are at a greater risk for adverse effects. Conversely poor metabolizers, individuals who convert almost no codeine into morphine, are at risk for …
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Unravelling Variability in Antidepressant Outcomes using Pharmacogenetic and Pharmacokinetic Strategies
… O-desmethylvenlafaxine (ODV). Incorporating CYP2D6 metabolizer status significantly enhanced the model’s predictive accuracy. CYP2D6 metabolizers showed different VEN clearance, VEN exposure, and active moiety (VEN plus ODV) exposure, where differences were mostly driven by CYP2D6 poor …
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From macromolecular crowding to transcriptional regulation: Exploring the complexities of cytochrome P450s, cannabinoids, and inflammation
… of the interactions of Cytochrome P450 2D6 (CYP2D6) and several of its polymorphisms with an array of phytocannabinoids (pCBs). CYP2D6 is a highly polymorphic CYP which has been shown previously to be inhibited by cannabidiol (CBD). In our current study, we examined the binding of eight pCBs …
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An investigation into the association between cytochrome P450 and glutathione S-transferase detoxification enzyme polymorphisms and human oral squamous cell carcinoma
… squamous cell carcinoma of the oral cavity. The CYP2D6 PM phenotype was associated with a significantly increased risk of oral cancer (p = 0.0012). The CYP2D6 PM and HET phenotypes appear to be markers for a putative tumour suppressor gene at or close to 22q12. The EM phenotype is a risk factor …
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The interactions of Propafenone and its enantiomers with the major human forms of cytochrome P450 in terms of inhibition and metabolic rates
… with the major cytochrome P450 isoforms (CYP2D6, CYP1A2, CYP3A4 and CYP2C19) to determine any stereospecific differences which may exist. This was conducted by measuring the in vitro metabolism of propafenone (racemate and enatiomers) and by developing CYP inhibition screens which could …
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Genetically engineering a new system for the expression of cytochrome P450 enzymes in insect cells using novel P450 reductases
… and studied the interactions of seven CYPs, CYP2D6, CYP3A4, CYP1A1, CYP1B1, CYP1A2, CYP2E1 and CYP2C8 in conjunction with different CPR species (the native human CPR, variants of human CPR and the yeast CPR) using the baculovirus expression system. In my studies I have found that different …
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Nuevos factores genéticos asociados a la predisposición de crisis en Porfiria Aguda Intermitente.
… en los genes de los citocromos CYP2C9, CYP2C19, CYP2D6, CYP3A4 y CYP3A5 que actúen como factores de susceptibilidad para la manifestación de crisis agudas en los portadores de PAI. Material y métodos: Se realizó un estudio retrospectivo de la ocurrencia de crisis (PAI manifiesta) en 50 individuos …
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The Relationship between methylation and genes associated with opioid response in humans.
… The promoter region methylation of ABCB1/MDR1, CYP2D6 and OPRM1 genes were analysed by pyrosequencing in smoking, opioid exposed and control pilot populations. Genetic variations within ABCB1/MDR1, COMT, CYP2B6, CYP2D6 and OPRM1 genes were also investigated. Tissue opioid concentrations were …
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Synthesis and characterisation of imprinted polymeric receptor mimics
… the metabolically important cytochrome isoform CYP2D6. The MIPs re-bound their templates and various cross-reactivities were encountered for test compound/drug recognition. One MIP in particular exhibited a rational discrimination amongst the related synthetic templates and was reasonably …
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Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms
… the other major CYP isoforms namely, CYP2C9 and CYP2D6 and developing a new immobilisation-free technology with label-free mass spectrometric identification and quantitation of metabolites formed. The goals of expansion of functional CYP microarrays were achieved by using microarray or confocal …
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Metabolic Studies on 1-Cyclopropyl-4-phenyl-1,2,3,6-tetrahydropyridinyl Derivatives by HPLC and LC-ESI/MS
… human hepatic cytochrome P450 has shown that CYP2D6 catalyzes the formation of cinnamaldehyde, the N-descyclopropyl, pyridinium and hydroxylated products. CYP3A4 is responsible for the formation of the N-descyclopropyl and pyridinium species and cinnamaldehyde but it does not mediate any …
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In vitro metabolism studies to inform physiologically-based pharmacokinetic modelling of mefloquine, ritonavir and proguanil
… by a number of enzymes, namely CYP1A2, CYP2D6, CYP2C19 and CYP3A. This confirms reported data for CYP2C19 and CYP3A, and provides new data for CYP1A2 and CYP2D6. Lastly, ritonavir was found to be metabolized by CYP2D6 and CYP3A. These determined fm,CYPs were then used, along with …
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