Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"CYP2C9"”.
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Meta-analysis of the population and phenotypic expression of CYP2C9/2C19 polymorphism on drug metabolism in different ethnicities
… studies. In this thesis, the prevalence of CYP2C9/2C19 alleles between different ethnicities has been estimated through meta-analysis and the population genetic principle. The clinical outcome of CYP2C9/2C19 allelic variation on the pharmacotherapy of epilepsy has been investigated; although …
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Bedeutung des Cytochrom-P450-2C9- und -3A5-Genpolymorphismus für Pharmakokinetik, Wirkungen und Nebenwirkungen von Delta-9-Tetrahydrocannabinol bei gesunden Probanden und Probandinnen
… dieser Studie untersuchten wir den Einfluss des CYP2C9- und-3A5-Genpolymorphismus auf die Pharmakokinetik sowie Wirkungen und Nebenwirkungen von 15 mg oral appliziertem Delta-9-THC bei 43 gesunden Probanden und Probandinnen. Dazu wurden zu vordefinierten Zeitpunkten Blut- und Urinproben gewonnen …
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Genetische Marker bei hausärztlichen Patienten mit oraler Antikoagulation
… wirkstoffabbauenden Enzyms Cytochrom-P450-2C9 (CYP2C9) aufweisen, benötigen zur Therapie geringere Warfarindosierungen als homozygote Wildtyp-träger und haben ein erhöhtes Risiko für Blutungskomplikationen.In Deutschland ist Phenprocoumon das am häufigsten verordnete Antikoagulanz. Phenprocoumon …
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The impact of the cytochrome CYP2C9*2 and *3 polymorphisms in the South African Caucasian population on warfarin therapy protocols
Please read the abstract in the section 00front of this document
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The role of warfarin pharmacogenomics on the time it takes to reach stable therapeutic International Normalized Ratio (INR) and on warfarin dose required to maintain stable therapeutic INR in Black African and Mixed Ancestry South Africans: a focus on CYP2C9 and VKORC1
… the Vitamin K epoxide reductase. Genes CYP2C9 and VKORC1 code for these two proteins, respectively. CYP2C9 and VKORC1 exhibit genetic polymorphisms that have been shown to affect warfarin response and favorably facilitate warfarin dosing and improve clinical outcomes. However, none of …
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Nuevos factores genéticos asociados a la predisposición de crisis en Porfiria Aguda Intermitente.
… del gen ALAS1 y en los genes de los citocromos CYP2C9, CYP2C19, CYP2D6, CYP3A4 y CYP3A5 que actúen como factores de susceptibilidad para la manifestación de crisis agudas en los portadores de PAI. Material y métodos: Se realizó un estudio retrospectivo de la ocurrencia de crisis (PAI manifiesta) …
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Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms
… format to the other major CYP isoforms namely, CYP2C9 and CYP2D6 and developing a new immobilisation-free technology with label-free mass spectrometric identification and quantitation of metabolites formed. The goals of expansion of functional CYP microarrays were achieved by using microarray or …
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Pharmacogenomics of warfarin: comprehensive evaluation of important warfarin genomic response factors
… and targeted proteins. Genetic variants in CYP2C9 and VKORC1 have been extensively studied on how they affect warfarin dose variability, culminating in several dosing algorithms incorporating genetic (i.e., CYP2C9*2, CYP2C9*3 and VKORC1 g.-1639G>A) and non-genetic factors (i.e., age, body …
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HEPATIC DIFFERENTIATION OF HUMAN AMNIOTIC EPITHELIAL CELLS AND IN VIVO THERAPEUTIC EFFECT ON ANIMAL MODEL OF CIRRHOSIS
… CELLS SECRETED ALBUMIN, EXHIBITED INDUCIBLE CYP2C9 AND CYP3A4 ENZYMATIC ACTIVITIES, WERE ABLE TO UPTAKE AND CLEAR INDOCYANINE GREEN, AND UPTAKE LOW-DENSITY LIPOPROTEIN. AFTER CELLULAR TRANSPLANTATION INTO NSG MICE WITH THIOACETAMIDE INDUCED CHRONIC LIVER FAILURE, HAECS SHOWED ENGRAFTMENT AND …
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Genetic polymorphisms in breast cancer in relation to risk and prognosis
… Study IV the frequencies of CYP2C8*3, CYP2C8*4, CYP2C9*2, CYP2C9*3, GSTM1*0 and GSTT1*0 were evaluated and haplotype blocks constructed. CYP2C8/9 *1/*4/*1/*1 was associated with a lower frequency of axillary lymph node involvement as compared with the wild type in tumors larger than 20 mm, OR …
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Exploring the effects of polymorphic variation on the stability and function of human cytochrome P450 enzymes in silico and in vitro
… assays were performed on a panel of CYP3A4 and CYP2C9 variants heterogeneously expressed in E.coli. All mutations predicted to alter protein function by stabilising or destabilising the apo-protein structure in silico were found to significantly alter the thermostability of the holo-protein in …
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Migreenin estolääkkeen amitriptyliinin metaboloitumisen geneettiset erot Itä- ja Länsi-Suomessa
… joista määritettiin kolmen CYP-entsyymin (CYP2C9, CYP2C19, CYP2D6) fenotyyppien esiintyvyys itä- ja länsisuomalaisissa. Tutkimustulosten mukaan eroavaisuudet fenotyyppien esiintyvyydessä itä- ja länsisuomalaisten välillä olivat maltillisia. Amitriptyliinin metaboliassa erityisen oleellisen …
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… supporting results: The C-allele at rs4918758 in CYP2C9 was associated with a 25% (15-44%) lower odds of dose reduction of quinine, p=1.6×10-5; the A-allele at rs9895420 in ABCC3 was associated with a 46% (24-62%) reduction in odds of dose reduction with doxazosin, p=1.2×10-4, and altered blood …
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Human Genetics, Psychotropic Drugs, and Acts of Violence
… More than 4 variant alleles for CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 or CYP3A4.</p> <p>• Three or more prescription medications, especially when an antidepressant or other psychoactive medication is prescribed.</p> <p>• An intermediate phenotype for CYP3A4.</p> <p>• Fluctuating levels of …
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Studies on pro-oxidant cytochrome P450 enzymes as drug discovery tools and the discovery that they also have a dual function as antioxidants
… compounds. (ii) CYP1A2, CYP2C19, CYP2D6, CYP2C9 and CYP3A4 are major liver enzymes that are widely used to study drug metabolism (i.e. metabolism of medicines). These particular CYPs metabolise medicines into more polar substances through such reactions as hydroxylation etc. Hence, CYPs …
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Characterisation of mammalian cytochrome P450 enzymes by their metabolic activities.
… with anti-CYP2C antibodies and sulphaphenazole (CYP2C9/10 inhibitor). These studies suggest that metabolism of harman by human liver microsomes is mainly by CYP1A2, with the additional involvement of CYP2C in the formation of the minor metabolite M2. Harman may therefore be a useful model …
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Emerging anabolic drugs - investigation of the in vitro and in vivo metabolism of selective androgen receptor modulators
… orthologues of human CYP2A6, CYP2B6, CYP2C8, CYP2C9 (only ostarine), and CYP3A4 were implicated in metabolism of ostarine and LGD-4033 across species. <br/><br/>To expand on the liver-based in vitro tools employed in this thesis, the metabolism of SARM compounds ostarine, LGD-4033, and RAD140 …
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Advancing precision medicine: harnessing data from diverse sources and individuals to predict medication efficacy and safety.
… (n=236 and n=198), we found significantly higher CYP2C9*3 allele frequencies (18.9% vs. 3.0%) and lower predicted warfarin maintenance doses (19.8 vs. 21.3 mg/week) compared to other East Asians. These genetic differences, combined with non-genetic factors, result in distinct warfarin dosing …