Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"CYP2C8"”.
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Impact of CYP2C8 single nucleotide polymorphisms on in-vitro metabolism of imatinib to N-desmethyl imatinib
… metabolite N-desmethyl imatinib by CYP3A4 and CYP2C8. In vitro human liver microsome (HLM) studies indicate imatinib autoinhibition of CYP3A4-mediated metabolism, suggesting a more significant role for CYP2C8 upon chronic dosing. CYP2C8 is polymorphic and functional effects of the major CYP2C8 …
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Genetic polymorphisms in breast cancer in relation to risk and prognosis
… 0%, P=0.018). In Study IV the frequencies of CYP2C8*3, CYP2C8*4, CYP2C9*2, CYP2C9*3, GSTM1*0 and GSTT1*0 were evaluated and haplotype blocks constructed. CYP2C8/9 *1/*4/*1/*1 was associated with a lower frequency of axillary lymph node involvement as compared with the wild type in tumors …
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Valor pronóstico y predictivo de polimorfismos en genes relacionados con el metabolismo y el mecanismo de acción del cabazitaxel en pacientes con cáncer de próstata avanzado
… de cabazitaxel (CYP3A4, CYP3A5, ABCB1, TUBB1, CYP2C8). La presencia/ausencia de alelos mutados de los SNP seleccionados, se correlacionó con las características clínicas de CPRCm, la SLP, la SG y la toxicidad de cabazitaxel mediante la realización de análisis univariante y multivariante. Para …
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Human host and malaria parasite genome variations to susceptibility to malaria
… As part of confirmation, genotyping for CYP2C8 SNPs was carried out in native South African population groups, which we have access to our laboratory. CYP2C8 is particularly interesting because of its central involvement in the metabolism of some of the major antimalarial drugs. Results: …
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
… cell lines. The study also showed that CYP2A6, CYP2C8, CYP2C18, CYP2F1 and CYP4Z1 mRNA were expressed in certain BCCs that were characterised by oestrogen receptor (ER) - ER-positive Caucasian and ER-negative African-Caribbean BCCs. Although no differences in P450 mRNA were observed between the …
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Human Genetics, Psychotropic Drugs, and Acts of Violence
… <p>• More than 4 variant alleles for CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 or CYP3A4.</p> <p>• Three or more prescription medications, especially when an antidepressant or other psychoactive medication is prescribed.</p> <p>• An intermediate phenotype for CYP3A4.</p> <p>• Fluctuating levels …
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Genetically engineering a new system for the expression of cytochrome P450 enzymes in insect cells using novel P450 reductases
… CYP3A4, CYP1A1, CYP1B1, CYP1A2, CYP2E1 and CYP2C8 in conjunction with different CPR species (the native human CPR, variants of human CPR and the yeast CPR) using the baculovirus expression system. In my studies I have found that different CPRs have different coupling efficiencies towards the …
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Clinical Drug-Gene and Drug-Drug-Gene Interactions for the Most Commonly Used Chronic Drugs in the UK
… gliclazide side effects and the association of CYP2C8*3 with reduced pioglitazone efficacy. We also report some other novel and potentially important associations from both the DG and DDG interaction studies.<b><br/></b><b><br/></b><b>Conclusion</b>: The work in this thesis highlights the value …
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Genetic and non-genetic determinants of drug response in type 2 diabetes
… (<i>SLCO1B1</i> 521T>C) andmetabolizing (CYP2C8*<i>3</i>) proteins withHbA1c reduction and weight gain to thiazolidinediones (TZDs), we showed a largeclinical impact on the therapeutic response to rosiglitazone. Lastly, in a meta-analysis consisting of 1,235T2D subjects treated with …
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Emerging anabolic drugs - investigation of the in vitro and in vivo metabolism of selective androgen receptor modulators
… and porcine orthologues of human CYP2A6, CYP2B6, CYP2C8, CYP2C9 (only ostarine), and CYP3A4 were implicated in metabolism of ostarine and LGD-4033 across species. <br/><br/>To expand on the liver-based in vitro tools employed in this thesis, the metabolism of SARM compounds ostarine, LGD-4033, and …
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Pharmacological targets for treatment of retinal neurodegenerations: new perspectives [Nuove prospettive sui target farmacologici per il trattamento della neurodegenerazione retinica]
… P2X3 e P2X4, insieme agli enzimi codificati da CYP2C8, LDHA e MAOB potrebbero essere degni di ulteriori indagini sperimentali per la mancanza di studi preclinici e clinici legati ad essi. In più, si è evidenziato il coinvolgimento di diversi geni noti per aver un ruolo nell’eziopatogenesi del …