Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CYP27B1"”.
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Synthesis of 20S-Hydroxyvitamin D3 Analogs and Their 1α-Hydroxyl Derivatives as Potent Anti-inflammatory Agents
… influence on the kinetics of 1α-hydroxylation by CYP27B1 were determined. Their corresponding 1α-hydroxyl derivatives were subsequently produced. Biological comparisons of these products showed different properties with respect to vitamin D3 receptor activation, anti-inflammatory activity, and …
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Expression und Funktion des Vitamin-D-Rezeptors in malignen Keimzelltumoren des Hodens
… NCOR2, TRIP15, GADD45, MAPKAPK2, CYP24A1 und CYP27B1 nach Vitamin-D-Stimulation.
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The roles of vitamin D in cutaneous wound healing: In vitro and ex vivo studies of the effect of 1,25(OH)2D3 and its precursors on human dermal fibroblasts and epidermal keratinocytes in cutaneous wound healing
… via 25-hydroxylase (CYP2R1) and 1α-hydroxylase (CYP27B1). Another enzyme, 24-hydroxylase (CYP24A1), regulates local levels by inactivating 1,25(OH)2D3. While recent studies have shown that absence of VDR or 1,25(OH)2D3 impairs formation of granulation tissue during wound healing in mice, little …
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Déploiement et évaluation d’une offre de test de dépistage néonatal pour le rachitisme vitamino-dépendant de type 1A
… inherited disease caused by variants in the CYP27B1 gene, which is required for vitamin D activation. Although rare worldwide, the prevalence is 1 in 2916 births in the Saguenay-Lac-Saint-Jean (SLSJ), Haute-Côte-Nord (HCN) and Charlevoix regions. At birth, the affected children are normal in …
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Effects of vitamin D on pro-inflammatory cytokines associated with Non-alcoholic fatty liver disease
… mRNA and protein expression of VDR, IκBα, and cyp27B1 in HepG-2. Treatment of HepG-2s with calcitriol significantly decrease mRNA and protein expression of importin-α3 and attenuate the effects of pro-inflammatory cytokines to induce importin-α3 mRNA and protein expression. IL-10, which is an …
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The Role of Vitamin D in Skeletal Muscle Function and Regeneration
… D. Skeletal muscle expresses both CYP27A1 and CYP27B1 encoding for the hydroxylases required to convert Vitamin D to 25[OH]D and subsequently the bioactive 1α-25-dihydroxyvitamin D3 (1α-25[OH]2D3) (Girgis et al., 2014b). Crucially, the Vitamin D receptor (VDR) is also present in skeletal muscle …