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Showing 1 to 3 of 3 for “"CYP27A1"”.
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Synthesis and evaluation of CYP27A1 inhibitors and NR0B2 agonists as anticancer immunomodulators
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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The impact of cholesterol and its metabolites on the ovarian tumor microenvironment and cancer progression
… in cholesterol metabolism pathways. Among them, CYP27A1 is highly expressed in myeloid cells and oxidizes cholesterol into 27-hydroxychoelsterol (27HC), which is the most abundant oxysterol and an endogenous signaling molecule. In addition, serum 27HC concentration closely correlates to that of …
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The Role of Vitamin D in Skeletal Muscle Function and Regeneration
… termed Vitamin D. Skeletal muscle expresses both CYP27A1 and CYP27B1 encoding for the hydroxylases required to convert Vitamin D to 25[OH]D and subsequently the bioactive 1α-25-dihydroxyvitamin D3 (1α-25[OH]2D3) (Girgis et al., 2014b). Crucially, the Vitamin D receptor (VDR) is also present in …