Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"CYP1B1"”.
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Genetic evaluation of cytochrome P450 expression in smoking and nonsmoking women
1. Regiospecific expression of CYP1A1 and CYP1B1 in human uterus of nonsmokers. The goal of this study was to investigate the expression of these isoforms in different regions of the human uterus. Expression was determined in the endometrium, endocervix and squamous (exocervix) regions from six …
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Identification de co-régulateurs impliqués dans la réponse transcriptionnelle induite par les récepteurs AhR et ER[alpha]
… cibles de AhR à savoir les gènes CYP1A1, CYP1A2, CYP1B1, suite au traitement avec le TCDD. Le niveau d'induction du gène CYP1A1 diminue alors que celui du gène CYP1B1 reste constant. Cela diminuerait le ratio CYP1A1/CYP1B1 et ferait augmenter le risque pour le cancer. En effet, CYP1A1 métabolise …
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Study of the aryl hydrocarbon receptor as a target for rational drug design
… and protein levels in Hep3B cells; however, the CYP1B1 induction is not affected. D2 suppresses the recruitment of Arnt to the cyp1a1 promoter but not to the cyp1b1 promoter, partly because the AhR/Arnt heterodimer binds better to the cyp1b1 DRE than to the cyp1a1 DRE. Interestingly, D2 has no …
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The Role of the Aryl Hydrocarbon Receptor in Tumor Growth and Chemoresistance
… the AHR by quantifying the expression levels of Cyp1b1 and Cyp1a1. Based on the results of the in vivo experiments, continued testing was conducted to examine the role of AHR inhibition in chemoresistance. Using MTT cell viability assays coupled with dosing of commonly used chemotherapeutics, the …
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In search of human cytochrome P450 1A1 enzyme inhibitor
… of three members; they are CYP1A1, CYP1A2 and CYP1B1. The mRNAs of CYP1A1 and CYP1B1 genes are known to be expressed in extra-hepatic tissues while that of the CYP1A2 gene is found in the liver amongst other tissues. Under normal circumstances, rarely has CYP1A1 protein expression been seen in …
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Toxicity of TCDD in the mouse antral follicle
… P450, family 1, subfamily b, polypeptide 1 (Cyp1b1). TCDD exposure for 48 hours increased levels of A4, without changing HSD3B1 protein, HSD17B1 protein, estrone (E1), T or E2 levels. Further, TCDD did not alter atresia rating, but it did down-regulate the AHR protein compared to vehicle. …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
… coding for the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2E1), sulphotransferase 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the metabolism or …
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Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state
… dehydrogenases (17βHSD1 and 2), CYP1B1, and catechol-O-methyltransferase (COMT) in an MCF10A-derived lineage cell culture model for basal-like human breast cancer progression and in ERα-positive luminal MCF7 breast cancer cells. Low levels of ERα and ERβ mRNA were present in …
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Studies on pro-oxidant cytochrome P450 enzymes as drug discovery tools and the discovery that they also have a dual function as antioxidants
… objectives in mind. (i) CYP1A1, CYP1A2, and CYP1B1 are enzymes highly up-regulated in lung cancers that are caused by inhaling or coming into contact with polyaromatic hydrocarbons (PAHs) which exist in cigarette smoke, in the close proximity to petrochemical industries and in environments …
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Effect of Mesoporous Silica-Loaded Anticancer Drugs on 3D vs 2D Models of Colon Cancer Cells
… of CYP enzymes such as CYP1A1, CYP1A2 and CYP1B1 in 3D spheroids than in 2D monolayer cells (p = 0.0069, p = 0.00001, and p = 0.0004, respectively). Treatment with DMU121MSN (p < 0.001) and OXAMSN (p < 0.01) increased CYP1A1, CYP1A2, and CYP1B1 expression in both 2D and 3D cellular models. …
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Zebrafish cardiovascular cDNA microarrays : expression profiling and gene discovery in embryos exposed to 2,3,7,8-Tetrachlorodibenzo-ρ-dioxin
… ≥1.8-fold (p-values ≤5x10-4), and only CYP1A and CYP1B1 were induced >4- fold. Transcriptional responses to TCDD were highly dose-dependent, and adaptive responses were a prevalent feature of TCDD-modulated gene expression. Microarray analyses indicated induction of genes in three major functional …
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Xenobiotic Metabolism Genes and Clubfoot
… two null alleles in eight genes (CYP1A1, CYP1A2, CYP1B1, CYP2A6, EPHX1, NAT2, GSTM1 and GSTT1) were genotyped in a dataset composed of nonHispanic white and Hispanic multiplex and simplex families. Only one SNP in CYP1A1, rs1048943, had significantly altered transmission in the aggregate and …
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Isolation and effects of citrus limonoids on cytochrome p450 inhibition, apoptotic induction and cytotoxicity on human cancer cells.
… and hydroxylase activities of CYP1A2, CYP1B1, CYP3A4 and CYP19, using specific substrates such as ethoxyresorufin (ethoxyresorufin O-dealkylase, EROD), methoxyresorufin (methoxyresorufin O-dealkylase, MROD), and dibenzylfluorescein (DBF), were found to be significantly (P < 0.001) …
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Cytochrome P450 mRNA profile in human breast cancer cell lines.
… expression of target genes. Results showed that CYP1B1, CYP2D6, CYP2J2, CYP2R1, CYP2U1 and CYP4X1 mRNA were present in all cell lines. The study also showed that CYP2A6, CYP2C8, CYP2C18, CYP2F1 and CYP4Z1 mRNA were expressed in certain BCCs that were characterised by oestrogen receptor (ER) - …
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Synthesis of Novel CYP1 Activated Heterocyclic Anticancer Prodrugs
… endogenous and exogenous substrates. CYP1A1 and CYP1B1 have been found to be over-expressed in tumour cells whilst undetected or present in very low levels in corresponding normal tissue. This presented a novel target for the development of anti-cancer prodrugs, which would remain non-toxic until …
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Genetically engineering a new system for the expression of cytochrome P450 enzymes in insect cells using novel P450 reductases
… of seven CYPs, CYP2D6, CYP3A4, CYP1A1, CYP1B1, CYP1A2, CYP2E1 and CYP2C8 in conjunction with different CPR species (the native human CPR, variants of human CPR and the yeast CPR) using the baculovirus expression system. In my studies I have found that different CPRs have different …
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An investigation into the metabolic activation of novel chloromethylindolines by isoforms of cytochrome P450. Targeting drug metabolising enzymes in cancer: analysis of the role and function of selected cytochrome P450 oxidising novel cancer prodrugs
… AQ4N, Phortress and Aminoflavone. CYP1A1, CYP1B1, CYP2W1, and CYP4F11 have been identified as expressed in tumour tissue and surrounding stroma at high frequency compared to most normal tissues. Aim is to investigate the differential metabolism of novel chloromethylindoline by high …
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Investigating the Role of Cigarette Smoke and Alcohol in Oesophageal Squamous Cell Carcinoma
… by RT-qPCR. Seven genes, AHRR, ALDH3A1, CYP1A1, CYP1B1, GSTM3, GSTM4 and UGT1 A6, involved in xenobiotic metabolism and a number of other metabolic pathways were also altered in response to CSC and EtOH treatment. However, these genes' involvement require further confirmation by RT-qPCR. This …
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Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
… the involvement of CYP2A6, CYP2A13, CYP1A1, and CYP1B1 in smoking/nicotine-mediated toxicity leading to various types of cancers and hepatic toxicity. The majority of tobacco constituents, including nicotine, are metabolized and/or activated by CYP enzymes to generate reactive oxygen species …
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