Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 43 for “"CYP1A1"”.
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Characterization of serum-induced CYP1A1 expression and activity in mouse embryo fibroblasts
… in MEFs, we observed a super induction of CYP1A1 with newborn calf serum (NCS) in the presence (10nM/15nM) of TCDD. In addition to NCS, fetal bovine serum (FBS) also has the capability to yield a CYP1A1 super induction. These results suggest that components within the sera affect the …
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In search of human cytochrome P450 1A1 enzyme inhibitor
… family consists of three members; they are CYP1A1, CYP1A2 and CYP1B1. The mRNAs of CYP1A1 and CYP1B1 genes are known to be expressed in extra-hepatic tissues while that of the CYP1A2 gene is found in the liver amongst other tissues. Under normal circumstances, rarely has CYP1A1 protein …
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Cytochrome P450 1A1 and aromatase (CYP19) in cetaceans : enzyme expression and relationship to contaminant exposure
… to such exposures. Cytochrome P450 1A1 (CYP1A1) induction by planar halogenated aromatic hydrocarbons, including certain polychlorinated biphenyls (PCBs), has been correlated with toxic effects in rodents. CYP1A1 expression was measured in multiple organs from beluga whales and …
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Tetrachlorobiphenyl metabolism, toxicity, and regulation of cytochrome P50 expression in a marine teleost fish
… strong and sustained induction of hepatic CYP1A1 mRNA, protein content, and catalytic activity. A high TCB dose (5.0 mg/kg) elicited similar, strong induction of hepatic CYP1A1 mRNA, but not of CYP1A1 protein content or catalytic activity. This post-transcriptional "suppression" at the high …
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Characterization of resistance to halogenated aromatic hydrocarbons in a population of Fundulus heteroclitus from a marine superfund site
… examined the inducibility of cytochrome P4501A1 CYP1A1 in fish from NBH and Scorton Creek SC, reference site. Despite higher PCB concentrations in NBH than in SC fish - -1 500-fold - CYP1A1 expression, in most tissues, was not higher in NBH fish than in SC fish. Glutathione S-transferase GST and …
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Le poulamon atlantique (Microgadus tomcod) de l'estuaire de la rivière Miramichi et la truite arc-en-ciel (Oncorhynchus mykiss): l'effet des usines de transformation de bois de la Miramichi et l'induction du système enzymatique cytochrome P4501A1
… a mis en évidence l’induction de l’ARNm CYP1A1 en laboratoire chez la truite arc-en-ciel (Oncorhynchus mykiss) exposée à des effluents provenant de l’usine de pâte à kraft blanchie à Newcastle, Nouveau-Brunswick. Cette expérience et deux autres effectuées avec le poulamon atlantique …
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Identification de co-régulateurs impliqués dans la réponse transcriptionnelle induite par les récepteurs AhR et ER[alpha]
… des gènes cibles de AhR à savoir les gènes CYP1A1, CYP1A2, CYP1B1, suite au traitement avec le TCDD. Le niveau d'induction du gène CYP1A1 diminue alors que celui du gène CYP1B1 reste constant. Cela diminuerait le ratio CYP1A1/CYP1B1 et ferait augmenter le risque pour le cancer. En effet, …
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An investigation into the metabolic activation of novel chloromethylindolines by isoforms of cytochrome P450. Targeting drug metabolising enzymes in cancer: analysis of the role and function of selected cytochrome P450 oxidising novel cancer prodrugs
… including AQ4N, Phortress and Aminoflavone. CYP1A1, CYP1B1, CYP2W1, and CYP4F11 have been identified as expressed in tumour tissue and surrounding stroma at high frequency compared to most normal tissues. Aim is to investigate the differential metabolism of novel chloromethylindoline by high …
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Genetic evaluation of cytochrome P450 expression in smoking and nonsmoking women
1. Regiospecific expression of CYP1A1 and CYP1B1 in human uterus of nonsmokers. The goal of this study was to investigate the expression of these isoforms in different regions of the human uterus. Expression was determined in the endometrium, endocervix and squamous (exocervix) regions from six …
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Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state
… cells, pre-confluent cells had higher levels of CYP1A1 mRNA and greater activation of an AhR-responsive luciferase reporter, demonstrating that AhR was active in the pre-confluent cells. AhR and aryl hydrocarbon receptor nuclear translocator mRNA and protein levels were also higher in …
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Xenobiotic Metabolism Genes and Clubfoot
… SNPs and two null alleles in eight genes (CYP1A1, CYP1A2, CYP1B1, CYP2A6, EPHX1, NAT2, GSTM1 and GSTT1) were genotyped in a dataset composed of nonHispanic white and Hispanic multiplex and simplex families. Only one SNP in CYP1A1, rs1048943, had significantly altered transmission in the …
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The Role of the Aryl Hydrocarbon Receptor in Tumor Growth and Chemoresistance
… quantifying the expression levels of Cyp1b1 and Cyp1a1. Based on the results of the in vivo experiments, continued testing was conducted to examine the role of AHR inhibition in chemoresistance. Using MTT cell viability assays coupled with dosing of commonly used chemotherapeutics, the effects of …
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Study of the aryl hydrocarbon receptor as a target for rational drug design
… D2 suppression. D2 suppresses the induction of CYP1A1 at both the message and protein levels in Hep3B cells; however, the CYP1B1 induction is not affected. D2 suppresses the recruitment of Arnt to the cyp1a1 promoter but not to the cyp1b1 promoter, partly because the AhR/Arnt heterodimer binds …
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Genetic polymorphisms in the drug metabolizing genes and their roles in the development of oesophageal cancer
… in the genes coding for the cytochrome P450 (CYP1A1, CYP1A2, CYP1B1, CYP2E1), sulphotransferase 1A1 (SULT1A1), glutathione S-transferases (GSTT1. GSTM1 and GSTP1) alcohol dehydrogenase (ADH2 and ADH3) and aldehyde dehydrogenase (ALDH2) because the products of these genes are involved in the …
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Effect of Comorbidities on HIV-1 Pathogenesis in Monocytic Cells
… a significant increase in the expression of CYP1A1, AOEs (SOD1 and catalase), ROS generation, caspase-3 cleavage activity, and cytotoxicity. However, acute treatment with BaP showed only an increase in the mRNA expression of CYP1A1. These results suggested that of the five PAHs tested, BaP is …
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Approaches for assessing the presence and impact of thyroid hormone disrupting chemicals in delphinid cetaceans
… Blubber morphology, cytochrome P450 1A1 (CYP1A1) expression in the skin-blubber biopsy, blubber and plasma PCBs, and plasma OH-PCBs were assessed in bottlenose dolphins (Tursiops truncatus). In addition, magnetic resonance (MR) images of the postmortem brain in situ were obtained from …
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Noxious Cellular Injury Triggers an Oxidative Stress Gene Response
… HSPA1B (fc: 2.20±0.35), and cytochrome P450 1A1 (CYP1A1) (fc: 3.24±1.06), matching NGS data trends. Extending CA venom stimulation to 8 hours significantly increased the gene expression of metallothionein 1X (MT1X, fc: 5.64±1.34) and peroredoxin-4 (PRDX4, fc: 3.29±0.43) compared to non-stimulated …
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Mechanisms by which natural polyphenols regulate the expression of cytoprotective genes
… two flavonoids can increase the mRNA level of Cyp1a1. Lastly, the effect of quercetin and kaempferol in vivo was also examined in animals by using C57BL/6 male mice. Only quercetin showed up-regulation of Cyp1a1 mRNA in the small intestine. An effect on Nqo1 and Nrf2 by the flavonoids observed …
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