Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"CYP19A1"”.
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Spectroscopic characterization of iron-oxygen intermediates in human aromatase (CYP19A1)
CYP19A1 or aromatase, is a human steroidogenic P450 important for estrogen biosynthesis in humans. Over activation of aromatase results in malignancies of the breast tissue, especially in post menopausal women. In fact, aromatase inhibitors constitute the front line therapy for estrogen receptor …
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Association of aromatase (TTTA)n repeat polymorphisms with central precocious puberty in girls.
… onset of puberty. The cytochrome P450 19A1 (CYP19A1) gene encodes an aromatase that is responsible for the conversion of androgens to estrogen, which is key step in estrogen biosynthesis. The aim of this study is to identify CYP19A1 gene mutations or polymorphisms in girls with central …
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Mechanistic investigation of human cytochromes P450 involved in hormone biosynthesis
CYP17A1 and CYP19A1 are the key cytochromes P450 involved in steroidogenesis. Mutations causing hypo- or hyper-activation of both these enzymes results in diseased states, including cancers. In addition to carrying out mono-oxygenation reactions, both CYP17A1 and CYP19A1 also catalyze carbon-carbon …
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Structural Dynamics and Reaction Reversibility of Specific vs. Promiscuous Detoxification Enzymes
… related, substrate-specific counterparts CYP19A1 and GSTA4-4. Two aspects of enzyme behavior are considered: (I) structural dynamics in the absence and presence of ligands, and (II) reversibility of catalysis.Chapters 2 and 3 describe the substrate-dependent structural dynamics of …
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Stress Fiber Formation and Migration Are Novel PGR-Dependent Pathways Initiated in the Granulosa Cells of the Ovulating Follicle
… within the basal granulosa cell layer. Using a Cyp19a1-Cre line, granulosa cell conditional ‘knockout’ mouse models for both Jam3 and vinculin were established. Surprisingly, neither model showed loss of ovulatory function. However, further investigation found evidence that the Cyp19a1-Cre line, …
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Variation in age at menarche and adult reproductive function: the role of energetic and psychosocial stressors
… at a promoter of the gene coding for aromatase (CYP19A1) along with farming during childhood significantly predicted age at menarche in a rural Polish population. We further identified a potential pathway by which increased cortisol concentrations increases CYP19A1 promoter I.4 methylation, which …
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Toxicity of TCDD in the mouse antral follicle
… levels for Cyp11a1, Cyp17a1, Hsd17b1, and Cyp19a1, but increased Hsd3b1 transcript. TCDD exposure particularly lowered both Hsd17b1 transcript and HSD17B1 protein. However, TCDD exposure did not affect levels of E1 in the media. The down regulation of the AHR protein in TCDD exposed …
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Toxicity and detoxification of imidacloprid in mouse ovarian follicles
… regulators (Star, Cyp11a1, Cyp17a1, Cyp19a1, Hsd3b1, and Hsd17b1), estrogen receptors (Esr1 and Esr2), and apoptotic factors (Bax and Bcl2). I found that DNI, but not IMI, inhibited follicle growth and caused follicles to rupture in culture compared to control. IMI increased …