Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"CYP19"”.
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Cytochrome P450 1A1 and aromatase (CYP19) in cetaceans : enzyme expression and relationship to contaminant exposure
Contamnant exposure has been associated with toxic effects in marine mammals. Studies on early biochemical and molecular responses prior to, but associated with, contaminant-induced toxicity will aid in understanding the susceptibility of cetaceans to such exposures. Cytochrome P450 1A1 (CYP1A1) …
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Toxicological evaluation of azole fungicides in agriculture and food chemistry
… Nebenwirkung der Azole betrachtet. Aromatase (CYP19) katalysiert die Demethylierung von Testosteron zu Östradiol und wird durch Azole gehemmt. Die Verringerung der Östrogenspiegel durch CYP19-Inhibition ist das Wirkprinzip der als Zytostatika genutzten Azole, bei den Fungiziden wird es als …
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Análisis molecular de los genes calpaína-5, calpaína-10 y CYP19 aromatasa y su implicación en el desarrollo del síndrome metabólico
… cromosoma 15 que contiene el gen de la enzima CYP19 aromatasa. Esta enzima cataliza la conversión de andrógenos a estrógenos, la última e irreversible reacción de la síntesis de estrógenos a partir de colesterol. Nuestra hipótesis de trabajo fue que la asociación entre CAPN10 y DMII podía estar …
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Isolation and effects of citrus limonoids on cytochrome p450 inhibition, apoptotic induction and cytotoxicity on human cancer cells.
… activities of CYP1A2, CYP1B1, CYP3A4 and CYP19, using specific substrates such as ethoxyresorufin (ethoxyresorufin O-dealkylase, EROD), methoxyresorufin (methoxyresorufin O-dealkylase, MROD), and dibenzylfluorescein (DBF), were found to be significantly (P < 0.001) reduced at micromolar …
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Methadone metabolism in placentas from preterm pregnancies
… CYP isoforms. The affinity of methadone to CYP19 remained relatively unchanged throughout gestation. However, the activity of the enzyme increased as gestation progressed, but showed wide variations between individual placentas. Taken together, it was shown that aromatase is the major enzyme …
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Buprenorphine metabolism by preterm placentas: A pilot study
… earlier gestational age placentas revealed that CYP19 remains the major metabolizing enzyme of buprenorphine but suggests additional enzymes may be involved, namely, CYP3A4, 1A1, 2E1, 2D6 and 2C19. Further studies must be conducted for conclusions to be drawn but we hope this report can …
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Estrogen sulfotransferase (sult1e1) expression and function in mcf10a-series breast epithelial cells: role as a modifier of breast carcinogenesis and regulation by proliferation state
… SULT2B1), steroid sulfatase (STS), aromatase (CYP19), 17β-hydroxysteroid dehydrogenases (17βHSD1 and 2), CYP1B1, and catechol-O-methyltransferase (COMT) in an MCF10A-derived lineage cell culture model for basal-like human breast cancer progression and in ERα-positive luminal MCF7 breast cancer …
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Effects of benzo[a]pyrene and CYP19a1b knockdown on zebrafish development
… endocrine disruptor and a carcinogen. Aromatase (CYP19) is a key enzyme in steroidogenesis playing a key role in the hypothalamus-pituitary-gonad feedback loop. We hypothesized that BaP would negatively impact cyp19a1b expression in zebrafish, in turn, adversely affecting development and …
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Diterpenes as models for the study of their effect on neural progenitor cells and on cytochrome p-450 enzymes
… inhibited two classes of CYPs: CYP3A4 and CYP19.