Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CYP enzyme"”.
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IN VITRO AND IN VIVO KINETIC MODELING OF DIAZEPAM METABOLISM
… of drug metabolism by various drug-metabolizing enzymes (DMEs). Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of more than 60% of the top 200 prescribed drugs. X-ray and NMR data of CYP enzyme suggest that relatively large and flexible active sites are capable of …
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Translational high-dimesional drug interaction discovery and validation using health record databases and pharmacokinetics models
… for quantifying fraction of metabolism (fm) of CYP450 isozymes for FDA approved drugs. A reproducible data collection protocol was developed to extract key information from publicly available in vitro selective CYP enzyme inhibition studies. The fm was then estimated from the curated data. Then, …
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Effect of Mesoporous Silica-Loaded Anticancer Drugs on 3D vs 2D Models of Colon Cancer Cells
… stability observed at 4°C. Cytochrome P450 (CYP) enzymes play a central role in drug metabolism, with this study revealing differential expression in 2D vs 3D cellular models. Real-time PCR showed higher baseline expression of CYP enzymes such as CYP1A1, CYP1A2 and CYP1B1 in 3D spheroids than …
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Targeting CYP5122A1 and CYP51 for the Inhibition of Ergosterol Biosynthesis in Trypanosomatids
… new anti-trypanosomatid agents. Cytochrome P450 (CYP) 51 acts as a sterol C14α-demethylase during ergosterol biosynthesis and has been widely studied for its potential as a therapeutic target. CYP5122A1, another CYP enzyme found in both Leishmania and Trypanosoma species, has been demonstrated to …
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Developing novel systems for expression of intracellular membrane-bound human cytochrome P450 enzymes in baker’s yeast
Human cytochrome P450 (CYP) enzymes belong to a family of monooxygenase enzymes that are responsible for the metabolism, in a stereo-specific and stereo-selective manner, of diverse chemicals. These chemicals are often referred to as xenobiotics which are usually harmful and toxic to the human …
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In vitro metabolism studies to inform physiologically-based pharmacokinetic modelling of mefloquine, ritonavir and proguanil
… substantially mediated by the cytochrome P450 (CYP) enzyme superfamily. Thus, a valuable step in assessing the contribution of drug metabolism to variability in drug exposure is the measurement of the kinetics of CYP-mediated metabolism. However, this in vitro data needs to be translated to …