Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 134 for “"CYP"”.
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Detection of Biological Effects of Environmental Pollutants of the Kafue River on the Kafue Lechwe (KOBUS LECHE KAFUENESIS)by Characterization of Selected Biomarkers
… assessing the potential of Cytochrome P450 1A1 (CYP 1A1), Cytochrome P450 3A (CYP 3A) and Metallothionein1 (MT 1) as biomarkers in the Kafue lechwe in response to pollutants in the Kafue river. Kafue lechwe liver samples from Lochnivar GMA (n=23) and Blue Lagoon GMA (n=15) were analyzed for the …
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Surf Therapy for Children and Young People: A Systematic Literature Review of Qualitative Mental Health and Well-Being Outcomes. Exploring the Impact of Adaptive Surfing on the Mental Health and Well-Being of Children and Young People: A Multiperspectival Interpretative Phenomenological Analysis
… difficulties among Children and Young People (CYP) remaining prevalent, and existing services struggling to meet demand, there is a growing drive towards developing novel interventions and prevention strategies tailored to CYP. Surf therapy is gaining recognition as a potential mental health …
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Developing novel systems for expression of intracellular membrane-bound human cytochrome P450 enzymes in baker’s yeast
Human cytochrome P450 (CYP) enzymes belong to a family of monooxygenase enzymes that are responsible for the metabolism, in a stereo-specific and stereo-selective manner, of diverse chemicals. These chemicals are often referred to as xenobiotics which are usually harmful and toxic to the human …
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“The teachers, they try to understand, they say they understand, but they really don’t” An exploration into the educational experiences of secondary school pupils from military families
… explores how service children and young people (CYP) experience education. Service CYP may experience multiple school transitions throughout their education as a result of frequent family relocations which can affect their academic attainment, emotional wellbeing and friendships. Some service CYP …
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Mechanismus působení protinádorového léčiva ellipticinu v cílových tkáních jeho účinku
… ellipticinu se podílí cytochromy P450 (CYP) a peroxidasy za vzniku aktivačních a detoxifikačních metabolitů. Již v dřívějších pracích byly identifikovány jednotlivé isoformy CYP, které se podílí na oxidaci ellipticinu v různých tkáních (játra, plíce, ledviny) laboratorního potkana, …
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Genetically engineering a new system for the expression of cytochrome P450 enzymes in insect cells using novel P450 reductases
Human cytochrome P450 enzymes (CYPs) are a superfamily of haem-binding monooxygenase enzymes involved in the metabolism of xenobiotics such as toxins, carcinogens and pharmaceutical drugs as well as in the biosynthesis of cholesterol, vitamins and steroids. In recent years, the area of drug …
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The Role of Ovarian Metabolism in 4-Vinylcyclohexene Metabolites and 7,12-Dimethylbenz[a]anthracene Induced Ovotoxicity in Mice
… to an ovotoxic diepoxide (VCD) by hepatic CYP 2A and CYP 2B. DMBA is sequentially bioactivated to the ovotoxicant DMBA-3,4-diol-1,2-epoxide by hepatic CYP 1B1, microsomal epoxide hydrolase (mEH), and CYP 1A1/1B1 enzymes. Even though the liver is the primary organ metabolizing VCH and DMBA …
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Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
… macrophages in cigarette smokers. The role of CYP enzymes has not been studied in context with smoking/nicotine and HIV pathogenesis. However, there are several elegant studies that show the involvement of CYP2A6, CYP2A13, CYP1A1, and CYP1B1 in smoking/nicotine-mediated toxicity leading to …
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Genetic and Environmental Factors Related to Child and Parent Mental Health in the Context of Intellectual Disabilities
… health problems in children and young people (CYP) with intellectual disabilities (ID) and other neurodevelopmental disorders (NDDs) have long been a concern of research and clinical practice. Genetic diagnosis has become increasingly available for this group in the past decade, opening new …
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Comparative structural analysis of cytochrome P450 family CYP51 in the genus Cryptococcus
Cytochrome P450 monooxygenase CYP51 (sterol 14α-demethylase) is a well-known target of the azole drug fluconazole for treating cryptococcosis, a life-threatening fungal infection in immune-compromised patients in poor countries. Studies indicate that mutations in CYP51 confer fluconazole resistance …
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The lived experience of gaming and gambling: guiding practitioners' understanding for supporting children and young people.
… harms for children and young people (CYP) who play video games. Whereas alcohol and drug addiction are known to be associated with health risks, there is less awareness of the potential risks of gambling-like behaviour within video games, and the support services available to young …
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Exploring Educational Psychologists’ views and experiences of the Beads of Life narrative therapy based intervention
… that supports children and young people’s (CYP) emotional wellbeing by helping them to identify their strengths and view their problems as separate to themselves (Portnoy et al., 2016). Despite a core function of the Educational Psychologist (EP) role being to deliver effective interventions …
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Functional effects of cytochrome P450 variants on drug metabolism and adverse drug reactions: developing and extending high throughput P450 protein technology platforms
Cytochrome P450 (CYPs) are a superfamily of heme containing enzymes that catalyse a diverse range of biological reactions. They are responsible for over 80% of primary metabolism of currently available drugs and are therefore central to its medical importance. Investigating the effects of these …
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The modulation of cytochrome P450 activities by their membrane lipid environment
… be modulated. The membrane lipid environment of CYP isoforms has proved to be an essential component for their optimal activities and consequently investigations into this aspect of modulation are fundamental to many areas of research. The work described in this thesis investigates 3 methods for …
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Co-producing healthcare guidance for children and young people with ataxia telangiectasia (A-T) including the exploration and design of a home-based complex intervention
… quality of life for children and young people (CYP) living with ataxia telangiectasia (A-T), a rare and complex neurodegenerative condition. Addressing significant gaps in non-medical care provision, the project was structured into four interrelated work packages (WPs), each contributing …
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IN VITRO AND IN VIVO KINETIC MODELING OF DIAZEPAM METABOLISM
… enzymes (DMEs). Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of more than 60% of the top 200 prescribed drugs. X-ray and NMR data of CYP enzyme suggest that relatively large and flexible active sites are capable of multi-substrate binding. Due to the multiple …
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Raising a ‘red flag’ by not going to school: A grounded theory study of family coach intervention with persistent school non-attenders.
… in the long term. Children and young people (CYP) who are often absent from school are more likely than others to leave with few or no qualifications, to suffer mental health difficulties and to become criminal offenders in adult life. Family coaches work with families where a child has …
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Effect of Comorbidities on HIV-1 Pathogenesis in Monocytic Cells
… in monocytic cells via cytochrome P450 (CYP)-mediated oxidative stress pathway. They have also shown the role of cigarette smoke condensate (CSC), which contains numerous organic compounds such as polyaryl hydrocarbons (PAHs), on cytotoxicity and HIV-1 replication in monocytic cells. …
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Identification of Cyclophilin gene family in soybean and characterization of GmCYP1
I identified members of the Cyclophilin (CYP) gene family in soybean (Glycine max) and characterized the GmCYP1, one of the members of soybean CYP. CYPs belong to the immunophilin superfamily with peptidyl-prolyl cis-trans isomerase (PPIase) activity. PPIase catalyzes the interconversion of the …
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Exploring teachers' experiences of working with transgender young people in Northern Ireland
… teaching transgender children and young people (CYP) in the NI context. Using an exploratory qualitative research design, eight semi-structured interviews were completed and analysed using Thematic Analysis. Analysis of the data extracted through interview highlighted key aspects of teacher …
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