Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CYLD"”.
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The role of the deubiquitinating enzyme CYLD and its substrate BCL-3 in solid tumors
The tumor suppressor CYLD and the proto-oncogene BCL-3 are known to be deregulated in various cancer types. The molecular background of how these genes participate in carcinogenesis is not fully understood. CYLD is a deubiquitinating enzyme known to specifically target lysine 63 linked ubiquitin …
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Ubiquitin Mediated Regulation of NF-kappa B Signaling
… are targeted for proteasomal degradation and how CYLD negatively regulates NF-κB signaling. In these studies, I investigated the molecular mechanisms involved in the regulation of IκBalpha degradation. Using a siRNA approach, NPL4 was shown to be required for IκBalpha degradation. In vitro …
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The Role of K63-Linked Ubiquitination Cycles In Akt Kinase Activation
… regulate Akt activation, we have identified that CYLD as a DUB for Akt, and CYLD inhibited growth factor-induced ubiquitination and activation of Akt. Under serum-depletion condition, CYLD interacts with Akt and keep Akt under inactive state by directly removing K63-linked ubiquitination of Akt. …
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Biochemical and Genetic Studies on CC2D1A, a new NF-κB Activator and a Regulator of Synaptic Functions
… and an essential regulator of IKK complex, NEMO. CYLD, a deubiquitination enzyme specific for Lysine-63 linked polyubiquitin chains, negatively regulates the activity of CC2D1A. These results suggest that CC2D1A activates NF-κB through the canonical IKK pathway. In an attempt to identify the …
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Haploid reporter screens aimed at identification of NF-kappaB regulators
… S resistance gene (BSR) reporter and identified CYLD, a known negative regulator of NF-KB, demonstrating that in principle this approach works. In the same screen, two members of the poorly characterized leucine-rich repeat-containing 8 (LRRC8) family of proteins appeared as significant hits. I …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
… The ubiquitin-editing enzyme A20 and the DUB CYLD were hits chosen to be validated from a ubiquitin family esiRNA screen. Again, these were found to interact with FLIP by immunoprecipitation in a FLIP-ubiquitinationdependent manner and reduced FLIP'S ubiquitination when silenced.<br/><br/> …