Global ETD Search
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Showing 1 to 4 of 4 for “"CXXC Domain"”.
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Critical Functions Specified by the MLL CXXC Domain Determine Leukemogenic Capacity
… functional role of amino acids within the MLL CXXC domain to determine how specific residues contribute to leukemogenic capacity.</p> <p>MLL fusion proteins retain the amino-terminal portion of MLL including the CXXC DNA-binding domain while the carboxy-terminal portion is comprised of a fusion …
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The Specific Role of the MLL CXXC Domain in MLL Fusion Protein Function
… novel fusion proteins that cause leukemia. The CXXC domain of MLL is a cysteine rich DNA binding domain with specificity for binding unmethylated CpG-containing DNA. The CXXC domain is retained in oncogenic MLL fusions, and is absolutely required for the fusions to cause leukemia. This project …
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Maintaining Proper Levels of DNA Methylation Marks Through the TET Family is Critical for Normal Embryo Development in Pigs
… cells, only the pTET3L isoform, which contains CXXC domain that carry DNA binding property, was verified in mature porcine oocytes. Expression level of the pTET3L isoform was much higher in mature oocytes compared to that in somatic cells and tissues. In addition, the transcript level of this …
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Tet1: A Unique Dna Demethylase For Maintenance of Dna Methylation Pattern
… we show that overexpression of TET1 catalytic domain alone (TET1-CD) but not full length TET1 (TET1-FL) induces global DNA demethylation in HEK293T cells. Genome-wide mapping of 5hmC further reveals a unique regulation pattern of 5mC by TET1-FL, where its 5hmC production is relatively inhibited …