Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"CXCR5"”.
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Increased BCA-1 Expression and Attenuated Apoptosis in Epithelial Cells in Helicobacter pylori-associated Low Grade Gastric MALT Lymphogenesis
… situ hybridization for BCA-1 and its receptor, CXCR5, and TUNEL staining for apoptosis were done, respectively. We tested a change of BCA-1 and CXCR5 using in situ hybidization after H. pylori eradication in 28 patients, after which the complete remissions of MALToma were achieved. Also, we …
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Follicular Regulatory T cell migration and differentiation
… cells. A unique feature of Tfr cells is their CXCR5-dependent localisation within the GC. Therefore, genetic strategies that exclude Treg cells from entering the GC are a rational approach to generating a mouse model that lacks Tfr cells. To this end, I generated a strain of mice that lacks …
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Microglial Modulation of Neuronal Autophagy: Uncovering Cytokine-Mediated Pathways
… were found. Instead, two receptor-ligand pairs, CXCR5-CXCL13 and CXCR3-CXCL10, were identified as inducers of autophagy. CXCL13, the ligand for CXCR5, enhanced autophagy in several neuronal models, including primary mouse neurons and iPSC-derived neurons. Similarly, CXCL10 promoted autophagy in …
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Regulation of Autoimmune Germinal Center Reaction By Tfh Cells and Application of Tfr-Like Cells For The Treatment of Autoimmune B Cell Responses
… that Foxp3<sup>+</sup> Treg cells expressing CXCR5 can migrate into the germinal center (GC) zone where they specifically suppress GC reactions <em>in vivo</em>, presumably by directly suppressing B cells and/or Tfh cells. These CXCR5<sup>+</sup> Foxp3<sup>+</sup> Treg cells are termed as …
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Investigating the role of CD28 costimulation and IL-4/IL-13 responsive myeloid and lymphoid cells during helminth infections in mice
… abrogated humoral immunity and failure to expand CXCR5⁺ TFH cells.
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… were expressed on major T cell populations with CXCR5, CXCR6, CCR4 and CCR5 on minor populations. Tumour cells expressed CXCL10, CXCL12 and CCL21. Vessels expressed ICAM-1, CXCL12, CCL17 and CCL21. Tumour cell lines secreted factors that mediated chemotaxis of lymphoblasts in vitro and TIL …
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T Helper Cell Dysfunction in ANCA Associated Vasculitis
… T helper (PTH) cells, characterised by the PD1+CXCR5- phenotype, was described in the context of auto-immune diseases, driving organ inflammation. These pathogenic cells were shown to infiltrate sites of inflammation and have the necessary machinery to provide B cell help in the peripheral …
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Investigating pulmonary vascular B cells
… behaviour which can be mediated by CD49e or via CXCR5/CXCL13. Blocking CD49e decreased the amount B cell-neutrophil interactions taking place within the lung capillaries, and providing exogenous CXCL13 or neutralizing endogenous CXCL13 would respectively increase and decrease the amount of …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
… tonsils. This subset expressed low-levels of CXCR5 and ICOS (CXCR5loICOSlo) and helped naïve B cells more efficiently than GC-Tfh cells through high IL-21 production. Notably, CXCR5loICOSlo Tfh cells lacked the capacity to help GC-B cells due to FAS-L expression. This study shows that …
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REGULATION OF ADAPTIVE IMMUNE RESPONSES TO PLASMODIUM CHABAUDI MALARIA INFECTION
… the expression of the Tfh chemokine receptor CXCR5, but only Blimp-1 deficiency increased the proportions of Th1-like Tfh cells. STAT3 TKO mice had more IFN-γ+ Th1 memory cells, and were protected from reinfection. Since persistent immune stimulation can promote Tfh development, we treated …
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Elucidating the role of BCL6 in helper T cell activation, proliferation, and differentiation
… differentiation, including its role in sustained CXCR5 surface expression, a signature marker for TFH cells. This model also allowed us to recognize the role of BCL6 in promoting the expression of PD-1, another key surface marker for TFH cells. Without BCL6, CD4+ T cells cannot express PD-1 at the …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
… tonsils. This subset expressed low-levels of CXCR5 and ICOS (CXCR5loICOSlo) and helped naïve B cells more efficiently than GC-Tfh cells through high IL-21 production. Notably, CXCR5loICOSlo Tfh cells lacked the capacity to help GC-B cells due to FAS-L expression. This study shows that …
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Maintenance and function of antigen-specific CD4 T cells within the lung during tuberculosis
… factor Bcl6, and the chemokine receptor CXCR5. Furthermore we find that a majority of KLRG1+ IFN-γ producing CD4 T cells are located in the lung-associated vasculature and not in the lung parenchyma as previously thought. However, the PD-1+ population that shares features with follicular …