Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"CXCR4"”.
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Synthesis and Characterisation of Dual CCR7/CXCR4 Antagonists
… 7 (CCR7) and C-X-C chemokine receptor type 4 (CXCR4) plays an important role in lymph node metastasis in a variety of cancers. Indeed, in patients with tumours which are positive for CCR7 and/or CXCR4 expression, prognosis and survival are poorer than those whose tumours are negative for these …
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Molecular Mechanisms Regulating Chemokine Receptor CXCR4 Signaling and Trafficking
<p>CXCR4 is a G protein-coupled receptor (GPCR) that binds to the chemokine, stromal cell-derived factor-1 (SDF-1alpha; a.k.a. CXCL12). The SDF-1alpha/CXCR4 signaling axis plays an essential role during embryogenesis in the development of the heart, brain and vasculature and in the adult mediating …
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Développement et caractérisation de ligands du récepteur à chimiokine CXCR4
Le récepteur à chimiokine CXCR4 est à ce jour l’un des récepteurs couplés aux protéines G les plus étudiés. Le CXCL12, sa chimiokine endogène induit l’activation de plusieurs voies de signalisation cruciales à plusieurs processus physiologiques. Par ailleurs, dans de nombreux processus …
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The Role of SDF1/CXCR4 Signaling in Opioid-Induced Hypernociception
… I tested for changes in expression of SDF1 and CXCR4 signaling in the dorsal root ganglion following repeated morphine administration. Secondly, I investigated if opioid or non-opioid signaling was involved in the development of OIH and which of these receptor signaling cascades was responsible …
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CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse
… expression of CXCL12 and its cognate receptor CXCR4 have been reported in regions of rat brain that construct dopamine (DA) and glutamate (GLU) pathways such as ventral tegmental area (VTA), substantia nigra (SN), and nucleus accumbens (NAc). In the central nervous system (CNS), activation of …
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Regulation Of Neutrophil Homeostasis By Chemokines Signaling Through The Cxcr2 And Cxcr4 Receptors
… CXCR2 signals and retention-promoting CXCR4 signals, act antagonistically to regulate neutrophil release from the bone marrow. We generated mice with neutrophils genetically deficient for the receptors CXCR2: CXCR2-/-), CXCR4: CXCR4-/-), or both: double knock-out or DKO) in order to …
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Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of …
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Biochemical Characterization of CXCR4 Interactions With HIV -1, Natural Ligands and De Novo Designed Inhibitors
… cell, CD4 and a chemokine coreceptor, usually CXCR4 or CCR5. The natural ligand of CXCR4 is stromal cell-derived factor (SDF)-1alpha. Whereas the overlap between HIV-1 and SDF-1alpha functional sites on the extracellular domains of CXCR4 has been well documented, it is yet to be determined …
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Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma
… by FAP+ stromal cells. Targeting the CXCL12/CXCR4 pathway with AMD3100, a CXCR4 antagonist, resulted T cell infiltration and tumor regression with anti-PD-L1 therapy in the KPC model. The CAMPLEX clinical trial was initiated to assess the safety of a 7-day AMD3100 infusion and provide …
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Effects of Pharmacological and Genetic Disruption of Chemokine Receptor Cxcr4 In B-Cell Acute Lymphoblastic Leukemia
<p>The CXCR4 chemokine receptor plays a pivotal role in homing and retention of B-cell Acute Lymphoblastic Leukemia cells to bone marrow niches. The bone marrow stromal cells (BMSCs) constitutively secrete the CXCR4 ligand CXCL12, thus attracting leukemia cells and protecting them from cytotoxic …
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Untersuchungen zur Signaltransduktion des CXCR4 (CD 184) Chemokinrezeptors im Hinblick auf Vitalität und Migration humaner B-CLL-Zellen
… B-CLL-Zellen exprimieren auf der Oberfläche den CXCR4-Rezeptor (CD184) für das Chemokin SDF-1. Dieser Chemokinrezeptor spielt eine Schlüsselrolle für das Homing ins Knochenmark und die Stroma-vermittelte Apoptose-Resistenz. Stromazellen des Knochenmarks und Ammenzellen („nurse-like cells“, NLC) …
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Evaluation of new PET tracers for receptor tumour imaging
… showed significant tracer defluorination.The CXCR4 chemokine receptor and its natural ligand CXCL12 have essential physiological roles including cell trafficking for organogenesis at the embryonic development stage. They also have an established role in tumorigenesis with CXCR4 being …
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Die Bedeutung der Interaktion des Chemokins SDF-1 (CXCL12) mit CXCR4-Chemokinrezeptoren auf Leukämiezellen von Patienten mit Akuter Myeloischer Leukämie
… bzw. nur geringen funktionellen Expression der CXCR4 - Rezeptoren korreliert. Gesunde HSC haben eine vergleichsweise höhere Kapazität <br> zur Migration in das Stroma als AML - Zellen. Die Pseudoemperipolese der AML - Zellen kann mit verschiedenen Inhibitoren gehemmt <br> werden. Die …
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
… (IL-4 and IL-13) cytokines in the regulation of CXCR4 and CCR5 expression by monocytes, and the functional implications of Th1 and Th2 cytokine induced alterations in chemokine receptor expression on chemotaxis and HIV infection, are poorly understood and constituted the major aim of this …
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The roles of human cytomegalovirus US27 gene product during virus infection
… signaling of cellular chemokine receptor CXCR4. Enhanced cell survival and proliferation were mediated by the DRY box and C-terminal domain (CTD) of US27. PCR array analysis revealed that expression of US27 led to up-regulation of pro-survival factor Bcl-x, AP-1 transcription factor …
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Configurationally restricted bis-tetraazamacrocyclic complexes: chemokine receptor antagonists
The chemokine receptor CXCR4 is a trans-membrane protein which has been implicated in many physiological and pathological processes including cancer, rheumatoid arthritis and most significantly HIV replication. CXCR4 plays a vital role in embryonic development but is not essential at the …
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THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
… endothelial cells. SDF-1 alpha binds to the CXCR4 receptor on cell surfaces and to heparan sulfate in cell membranes and the extracellular matrix. We hypothesized that SDF-1 alpha is an important mediator of tumor vasculogenesis, recruiting bone marrow-derived endothelial progenitor cells to …
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The Role of Von Hippel-Lindau Protein in the Glomerulus
… de novo expression of the HIFα target gene Cxcr4. In glomeruli from mice with RPGN, the course of RPGN is markedly improved in mice treated with a blocking antibody to Cxcr4, whereas overexpression of Cxcr4 alone in podocytes of transgenic mice is sufficient to cause glomerular disease. …
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