Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"CXCR3"”.
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Charakterisierung des Chemokinrezeptors CXCR3 in humanen proximalen Tubuluszellen der Niere
Der Chemokinrezeptor CXCR3 , ein Mitglied der CXC Familie der Chemokinrezeptoren ist beteiligt an der Pathogenese chronisch entzündlicher Veränderungen, Autoimmunerkrankungen und der Metastasierung einiger Tumoren. <br>In der Niere wurde er vor allem im Zusammenhang mit Glomerulonephritiden …
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Die Rolle der Chemokinrezeptoren CXCR3 und CXCR7 bei den tumorogenen Einflüssen von CXCL11
… wirkt über die beiden Chemokinrezeptoren CXCR3 und CXCR7 und kontrolliert die Entwicklung verschiedener Organe, sowie die Hämatopoese, Angiogenese und die Lymphozytenwanderung. Bekannte pathophysiologische Funktionen des CXCL11 Systems umfassen des Weiteren die Kontrolle von …
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Die Bedeutung von Entzündung und reaktiven Sauerstoffspezies in der Intimahyperplasie
… sind Liganden des CXC-Chemokinrezeptors 3 (CXCR3) und locken chemotaktisch CXCR3 positive Entzündungszellen zum Ort der Gefäßverletzung. Daher wurde die spezielle Bedeutung des Chemokins CXCL10 in der Restenose untersucht. Dazu wurden CXCL10-defiziente Mäuse dem Femoralisverletzungsmodell …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
… vaccination induces exclusive activation of CXCR3+ blood Tfh subset at day 7. The emergence of activated CXCR3+ blood Tfh cells at day 7 correlated with the generation of protective antibody responses. Mechanistically, we found that activated CXCR3+ blood Tfh cells efficiently help memory B …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
… vaccination induces exclusive activation of CXCR3+ blood Tfh subset at day 7. The emergence of activated CXCR3+ blood Tfh cells at day 7 correlated with the generation of protective antibody responses. Mechanistically, we found that activated CXCR3+ blood Tfh cells efficiently help memory B …
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Chemokinrezeptorexpression auf T-Zellen in bronchoalveolärer Lavage und peripherem Blut bei Kindern mit chronischer Bronchitis und interstitiellen Lungenerkrankungen
… by flow cytometry. The percentages of CCR5+and CXCR3+ cells were determined within each T cell subset. Results are expressed as medians. For statistical analyses non-parametric tests (Wilcoxon, Mann-Whitney U) were applied. Results: In peripheral blood, the percentage of CXCR3+ T cells (16.4%, …
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Neuropathological characterization of transgenic mice with astrocyte-directed production of the CXC chemokine ligand 10
… expression analysis of the CXCL10 receptor, CXCR3, on <br>brain-infiltrating leukocytes from GFAP-CXCL10 mice indicated that there was significant enrichment for CXCR3-positive cells in the CNS of these mice compared with spleen. The majority of CXCR3-positive cells co-expressed the T cell …
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Microglial Modulation of Neuronal Autophagy: Uncovering Cytokine-Mediated Pathways
… two receptor-ligand pairs, CXCR5-CXCL13 and CXCR3-CXCL10, were identified as inducers of autophagy. CXCL13, the ligand for CXCR5, enhanced autophagy in several neuronal models, including primary mouse neurons and iPSC-derived neurons. Similarly, CXCL10 promoted autophagy in SH-SY5Y cell line …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… Treg cells to proliferate and acquire a T-bet+CXCR3+ phenotype, and to suppress the accumulation of CD4+Foxp3- and CD8+ effector T cells in the lungs of infected mice. Notably, when cognate Ag was expressed at high levels by antigen presenting cells, Treg cells also underwent substantial …
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Evolution of adaptive immune response from acute to chronic phase of hepatitis C virus infection
… expressing the chemokine receptors CCR2, CCR5, CXCR3, and CXCR6. Additionally, the studies revealed preferential expression of CXCR3 on HCV-specific CD8+ T cells in both chronic and acute HCV infection suggesting a key role for CXCR3 in regulation of HCV-specific CD8+ T cell trafficking to the …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… receptors were examined on infiltrating T cells. CXCR3, CXCR4 and CCR7 were expressed on major T cell populations with CXCR5, CXCR6, CCR4 and CCR5 on minor populations. Tumour cells expressed CXCL10, CXCL12 and CCL21. Vessels expressed ICAM-1, CXCL12, CCL17 and CCL21. Tumour cell lines secreted …
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Activation of T regulatory cells in Type II Immune Responses
… we examined chemokine receptor expression (CXCR3, CCR4, CCR6, CCR7) to identify T helper (Th-like) phenotypes. We also examined Treg activation and suppression-related molecules (CD39, Class II MHC, and PD-1) within each subpopulation. We further examined for changes in B cell subsets. We …
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The role of chemokines in the pathology of multiple sclerosis and other neuroinflammatory diseases
… T-lymphocytes predominantly expressing CXCR3 and CCR5, and foamy macrophages within the lesion predominantly expressing CCR3, CCR5 and CCR8. <i>In vitro</i> studies confirmed the production of chemokines and the expression of chemokine receptors by isolated rat astrocytes and microglia …
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Systems analysis of cytokine mediated communication and signaling
… INF[gamma] and TNF[alpha] for production of CXCR3 chemokines. Overall, this combination of modeling and experimental work has made contributions to understanding regulation of the cytokine environment in multicellular environments, as well as contributions of specific cytokines of interest to …
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EFFECTOR T CELL HOMING TO THE SMALL INTESTINAL MUCOSA
… receptors including CCR9, CCR6, CCR5, CXCR6 and CXCR3. Furthermore, since CCR9 was shown to be selectively induced on CD4+ T cell activated in mesenteric lymphnodes and expressed on the majority of CD4+ T cells entering into the small intestinal LP, CCR9 was suggested as a candidate receptors …
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Natural Killer Cell Recruitment and Activation Following Orthopoxviral Infection
… expression on NK cells. We determined that CXCR3 was intrinsically required for NK cell recruitment to the draining LN in an interferon-γ: IFN-γ) dependent manner. Additionally, a non-overlapping requirement for subcapsular sinus macrophages was required for NK cell …
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis.
… astrocytes. Even though astrocytes expressed CXCR3, similar negative results on calcium influx and downstream signalling pathways were observed for CXCL10. D6 chemokine decoy receptor expression was then assessed in vitro and in situ to further investigate the mechanism(s) of chemokine binding …
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Investigating the T cell-specific role of Interleukin-4 receptor alpha (IL-4Rα) in tuberculosis (TB)
… (CD44+KLRG1+ ) expressed reduced amounts of CXCR3, CD69, and CD103, which are all markers associated with poorer migration into the lung parenchyma. Importantly, these factors result in decreased survival in T cell-specific IL-4Rα mice. In conclusion this study demonstrates that absence of …
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Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… CD69 also being reduced in this group. Finally, CXCR3+CCR6+ nonconventional Th1 cells in the lungs were significantly reduced in PKD1mKO mice after repeated S. rectivirgula exposures. Discussion: Our results demonstrate that PKD1 in myeloid-lineage cells plays an essential role in the onset and …
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Single Cell Analysis of B Cell Responses to Malaria
… while some populations additionally express CXCR3. To examine the dynamics of alternative lineage cells after primary and recall immunization we tracked circumsporozoite protein specific B cells after plasmodium parasite vaccination in malaria naive volunteers. We found that alternative …
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