Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"CXCR2"”.
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Regulation Of Neutrophil Homeostasis By Chemokines Signaling Through The Cxcr2 And Cxcr4 Receptors
… gradients, specifically release-inducing CXCR2 signals and retention-promoting CXCR4 signals, act antagonistically to regulate neutrophil release from the bone marrow. We generated mice with neutrophils genetically deficient for the receptors CXCR2: CXCR2-/-), CXCR4: CXCR4-/-), or both: …
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
… the chemokine receptor CXC chemokine receptor 2 (CXCR2) plays an important role in promoting the progression of many cancers, including pancreatic cancer, one of the most lethal human malignancies. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl termini, which might …
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Chemokine CXCL7 Monomer, Homodimer, and Heterodimer: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
… vascular injury. CXCL7 function is coupled to CXCR2 receptor activation and interactions with sulfated glycosaminoglycans (GAG) that regulate receptor activity. CXCL7 exists as monomers and dimers and there is also evidence that it could form heterodimers. Currently, nothing is known regarding …
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Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin
… of CXCL1 and CXCL2 with their receptor CXCR2 on osteoclast precursor cells drives osteoclastogenesis in vitro and bone degradation in vivo. Our studies also demonstrated that in addition to its effects on osteoclasts, CXCR2 signaling axis is important for macrophage phenotype and …
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Chemokine CXCL7 Monomer, Homodimer, and Heterodimer: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
… vascular injury. CXCL7 function is coupled to CXCR2 receptor activation and interactions with sulfated glycosaminoglycans (GAG) that regulate receptor activity. CXCL7 exists as monomers and dimers and there is also evidence that it could form heterodimers. Currently, nothing is known regarding …
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Stat3 Controls The Neutrophil Migratory Response to Cxcr2 and Its Ligand Mip-2 (Cxcl2)
… and MIP-2 (Cxcl2), and their shared receptor CXCR2 (l8rb), also stimulate neutrophil mobilization, in contrast to SDF-1 (Cxcl12), which contributes to neutrophil retention in the bone marrow, requiring downregulation to promote neutrophil release. Using a murine model with conditional STAT3 …
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A Critical Role Of Cxcr2 Pdz Motif-Mediated Interactions In Endothelial Progenitor Cell Homing And Angiogenesis
… cytokines, and chemokines. Chemokine receptor CXCR2 and its cognate ligands are reported to mediate EPC recruitment and angiogenesis. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl terminus. The PDZ motif has been reported to regulate cellular signaling and functions. …
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
<p>CXC chemokine receptor 2 (CXCR2) is a G-protein coupled receptor which mediates signaling by binding to CXC chemokines CXCL1-3 and 5-8. In non-small cell lung cancer CXCR2 has been studied mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. However, there is …
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The role of chemokine receptor trafficking in regulating neutrophil migration to inflammatory sites
… two G-protein coupled receptors, Cxcr1 and Cxcr2. Through new in vivo biosensors, I show that Cxcr1 and Cxcr2 exhibit differential trafficking in response to endogenous gradients. Cxcr1 is extensively internalised whilst Cxcr2 is sustained on the cell membrane. Live-imaging of receptor …
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BIOLOGICAL AND TRANSDUCTIONAL EFFECTS OF ALLOSTERIC ANTAGONISTS ON THE ACTIVITY OF CHEMOATTRACTANT RECEPTORS
… on the surface of neutrophils, CXCR1 and CXCR2.It is thought that targeting both receptors may be necessary for optimal inhibition of PMN influx in several inflammation disorders such as post-ischemia reperfusion injury, pulmonary fibrosis, sepsis, psoriasis among other. DF 2156A is a …
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Inflammation and neutrophil recruitment in ageing subjects and patients with chronic obstructive pulmonary disease
… expression or shedding, but inhibition of CXCR2 gave young neutrophils and old migratory phenotype, suggesting altered downstream signalling. COPD neutrophils migrated with increased speed and reduced accuracy compared with control groups. They formed less pseudopodia when migrating, and …
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Generation of a novel pan-cancer chemokine receptor-modified CAR-T cell therapy directed towards nfP2X7
… into solid tumours. As the ligands for CXCR2, CXCR6 and CCR10 were found to be highly expressed in human breast and prostate tumours, these chemokine receptors were engineered to be co-expressed with the nfP2X7-specific CAR. In vivo delivery of CXCR2-expressing CAR-T cells resulted in …
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The Role of Gene Transcription and Inflammatory Cytokines in Bone Fracture Repair
… through deletion of CXC family receptor 2 (Cxcr2). Several members of the CXC chemokine family are among the most highly upregulated genes following skeletal injury. Despite this, their impact of fracture repair has not been reported. We used a global knockout mouse for Cxcr2 (Cxcr2 KO) to …
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Aging Effects on Acute Lung Inflammation After Burn Injury
… defects, as levels of the receptor for KC, CXCR2, is not different on neutrophils between age groups. In addition, we found that burn injury causes a significant decrease in CXCR2 on the surface of neutrophils, indicating that these cells are more susceptible to receptor desensitization. …
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The structural basis of chemokine binding affinity and receptor selectivity: Role of receptor N-terminal domain
… and dimers with their receptors CXCR1 and CXCR2. CXCR1 is specific and binds IL-8 alone with high affinity, whereas CXCR2 is promiscuous and binds both ligands with high affinity. The receptor structures are not known, and also due to the intrinsic difficulties of working with receptors, …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… receptor antagonist that binds CXCR1 and CXCR2 with high affinity. PolyI:C treatment significantly increased maternal levels of the chemokine CXCL1, the rodent analogue of IL-8 that binds CXCR1 and CXCR2. The offspring of polyI:C-treated dams showed impaired associative recognition memory …
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Proliferative and survival pathways in oesophageal cancer
… was to determine the role of EGFR, IGF-1R and CXCR2 in proliferation and survival of OSCC cells.
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Investigating the Role of Chemokines in Neutrophil Recruitment and Resolution During Inflammation
… of two chemokine receptors, Cxcr1 and Cxcr2, which were previously shown to mediate clustering and dispersal of neutrophils, respectively. I demonstrate that Cxcr1 recognises Cxcl8a and is rapidly internalised, whereas Cxcr2 recognises Cxcl8b and traffics in a manner consistent with …
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