Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"CXCL9"”.
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Antibacterial peptides - key players in host defense at epithelial surfaces
… high concentrations of the chemokines CXCL9/MIG, CXCL10/IP-10, CXCL11/I-TAC were found in tonsil fluid. Similarly, these chemokines were produced by activated pharyngeal epithelial cells in vitro. CXCL9/MIG was the predominant chemokine and also the most potent in killing GAS. …
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O papel das quimiocinas na resposta imune de pacientes com leishmaniose mucosa
… do que a produção de pacientes SC. Os níveis de CXCL9 foram significativamente maiores em paciente com LM comparados com paciente SC e grupo controle. De acordo com resultados preliminares observados foi possível detectar níveis significativamente mais elevados de CCL4 e CXCL10 em amostras de …
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Loss of Ptdss1 in tumor cells improves anti-PD-1 therapy
… of IFNγ-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1. Loss of PTDSS1 in tumor cells also led to increased expression of MHC-I, which was associated with increased expression of cytolytic function related genes in CD8<sup>+</sup> T cells and increased frequency of an …
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Die differentielle Expression tumorfördernder und tumorinhibierender Gene im ersten und zweiten Trimester der Schwangerschaft
… SFRP4, CXCL14) and an up-regulation for one (CXCL9) when comparing the first to the second trimester. In addition, one marker’s up-regulation (SLPI) could be further verified on protein level. The results of this study show that genes promoting tumor invasion (like SLPI, SFRP4 and CXCL14) are …
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Epitelinio kiaušidžių vėžio predikcinių imuninių žymenų paieška /
… Concentrations of CCL2/MCP-1, CXCL11/I-TAC, CXCL9/MIG, CCL3/MIP-1α, CCL4/MIP-1β, IFN-γ in the blood were significantly higher (p<0,05) in treatment-resistant versus sensitive patients. However, there was no difference in cytokine concentration (p>0,05) in tumor lysates between two different …
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Die Bedeutung von Entzündung und reaktiven Sauerstoffspezies in der Intimahyperplasie
… wird und die proinflammatorischen Chemokine CXCL9 (MIG, Monokine Induced by INF), CXCL10 (IP-10, INF inducible Protein of 10 kDa) und CXCL11 (I-TAC, Interferon inducible T cell-Chemoattractant) induziert. CXCL9, CXCL10 und CXCL11 sind Liganden des CXC-Chemokinrezeptors 3 (CXCR3) und locken …
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Surface proteins of Finegoldia magna interacting with the human host
… LL-37 and the antibacterial chemokine MIG/CXCL9. Furthermore, the protease cleaves fibrinogen and thereby inhibits fibrin network formation. To our knowledge, the first example of directed mutagenesis of F. magna is presented with the disruption of the sufA gene. The other identified …
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Microglial Modulation of Neuronal Autophagy: Uncovering Cytokine-Mediated Pathways
… was found to inhibit autophagy when activated by CXCL9, another CXCR3 ligand. Both CXCL13 and CXCL10 triggered autophagy through activation of the JNK pathway, as shown by increased cJUN phosphorylation, and this effect was reversed by JNK inhibition. These findings highlight the significance of …
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Protein FOG at the interface between G streptococci and human host defence lines
… and triggers secretion of the chemokines MIG (CXCL9) and IL-8 (CXCL-8). GGS are less susceptible than GAS, to antimicrobial effects of MIG in physiological NaCl concentrations corresponding to that of sweat and plasma but not of saliva, and also to these NaCl concentrations alone.
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Genetische Haplotypanalyse des distalen CXC-Chemokinclusters bei Patienten mit symptomatischer Cholelithiasis
… in a test series of healthy individuals in which CXCL9 serum concentrations were significantly associated with the presence of this CXC haplotype (p<0,001). Furthermore there was a significant negative correlation with the serum concentration of glucose at the presence of dCXC_4 (p=0,036). At last …
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Evaluation of the Role of Epstein-Barr virus and Cellular Gene Expression in Paediatric and Adult Transplant Recipients
… in PTLD. We also detected four cellular genes (CXCL9, CXCL10, CDC2, and CHI3L1) that were differentially expressed in PTLD vs. non-PTLD patients. To conclude, these findings suggest a basis for the likely microenvironment in which PTLD could develop. Further evaluation of candidate EBV and …
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Investigating the role of primary cilia loss in intrahepatic cholangiocarcinoma
… expression of pro-inflammatory cytokines such as Cxcl9, Cxcl10 and Cxcl11. However, the expression of neutrophil-specific chemokines such as Cxcl1, Cxcl2 and Cxcl5 was significantly suppressed. In concordance, immunohistochemical analysis revealed that neutrophil infiltration was frequently …
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STAT3, NF-κB, and Estrogen Receptor Beta: The Balance of Inflammation in K-ras Mutant Lung Adenocarcinoma
… several NF-κB anti-tumor target genes including CXCL9, a chemokine for primed T cells. Transcriptional profiling of the TIME revealed improved immune activation and anti-tumor skewing, as well as B cell signaling enrichment. Analysis of human LUAD data demonstrated negative correlations between …
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The Role of Human Guanylate Binding Proteins in Host Defense and Inflammation
… of several chemokines, including CXCL1, CXCL9, CXCL10, and CCL2, which act as chemoattractants for professional immune cells. This role in chemokine expression was independent of the GBP1 PBM and CaaX motif necessary for bacterial targeting, and extended not only to B. thailandensis, but …
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Dissecting the Role of Hedgehog Signaling in Tumor-associated Macrophages and Immunosuppression in the Tumor Microenvironment
… inhibition of C-X-C motif chemokine ligand 9 (CXCL9) and CXCL10 production by TAMs. Lastly, we demonstrated that Krüppel-like factor 4 (Klf4) mediates Hh-dependent TAM M2-polarization and the immunosuppressive function. Collectively, these findings highlight a critical role for tumor derived …
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Characterisation of the Tumour Microenvironment in Ovarian Cancer
… higher expression of the T cell chemoattractant CXCL9 and evidence of immunoediting. These findings suggest that multiple distinct tumour immune microenvironments can co-exist within a single individual and may explain in part the hetero- geneous fates of metastatic lesions often observed in the …
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CANNABINOID RECEPTOR 2 AGONIST REDUCES IMMUNE CELL MIGRATION IN NEUROINFLAMMATION VIA INHIBITION OF MATRIX METALLOPROTEINASE-9
… reduction in the expression of the chemokines CXCL9, 10, 11 and cytokines IL-23 and its receptor in CB2R agonist-treated cords. There was also a reduction in the expression of toll-like receptors (TLR1, TLR4, TLR6, and TLR7), which correlated with a decreased number of immunoreactive microglia. …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… induction of the IFNg-responsive genes CIITA and CXCL9. This suggests that IFNg signaling may be defective in the induction of IFNg-responsive genes in neonates compared to adults.</p> <p>To dissect the role of individual components of the immune system, we utilized CD46+ mice crossed to specific …