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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 20 for “"CXCL8"”.

  1. Effects of CXCL8 Overexpression on Tumor Cell Proliferation and Migration in an HNSCC Cell Model

    Christofakis, Emil Paul2014

    … the chemotactic cytokines known as chemokines. CXCL8 (Interleukin-8), a CXC ELR+ Chemokine mainly responsible for neutrophil chemoattraction, has beenimplicated in increased tumor proliferation, migration and angiogenesis. The current studytests the effects of CXCL8 on the tumor proliferation …

    vcu Repository record

  2. BIOLOGICAL AND TRANSDUCTIONAL EFFECTS OF ALLOSTERIC ANTAGONISTS ON THE ACTIVITY OF CHEMOATTRACTANT RECEPTORS

    N.P. MACHADO TORRESUniversità degli Studi di Milano2010

    … range of 1 to 2 nM. Despite its potency on both CXCL8 receptors, the effect of DF 2156A was highly specific. DF 2156A did not affect the activity of several related chemokine receptor belonging to both CC and CXC subfamilies. Our evidences show that DF 2156A is able to block different signaling …

    milano Repository record

  3. High MUC2 Biosynthesis and Production Augment Pro-Inflammatory Responses in Colonic Goblet Cells

    Kim, Ariel JayuGraduate Studies2023

    … investigated if the pro-inflammatory chemokine, CXCL8, was altered in WT and CRISPR/Cas9 MUC2KO human colonic goblet cells in response to E. histolytica. CXCL8 (IL-8) is a potent chemokine that recruits neutrophils to sites of inflammation, and symptomatic E. histolytica infections are marked by …

    calgary Repository record

  4. The role of the rho-associated coiled-coil containing kinase (ROCK) in cytokine-induced chemokine responses in intestinal epithelial cells

    Perey, Aaron C2017

    … but incomplete, suppression of TNF-α-induced CXCL8 expression in Caco-2 cells, indicating that ROCK is required for optimal CXCL8 production in IEC. ROCK inhibition also blocked TNF-α-stimulated JNK phosphorylation in Caco-2 cells but did not affect NF-κB activation, suggesting an explanation …

    binghamton Repository record

  5. Analysis of Cellular Transcriptomic Changes Induced by Merkel Cell Polyomavirus miRNA

    Akhbari, PouriaUniversity of Bradford2017

    … SP100, and the neutrophil stimulator chemokine, CXCL8. Moreover, dual luciferase assays revealed that SP100 and MAPK10 (a member of mitogen-activated protein kinases (MAPK) family which is involved in regulation of CXCL8 expression) are directly and specifically targeted and downregulated by MCV …

    bradford Repository record

  6. Response of salivary IL-8 to prolonged and interrupted sitting

    O’Rourke, NicholasUniversity of Ontario Institute of Technology2022

    … to determine the reliability of salivary IL-8 (CXCL8) and the response of IL-8 to prolonged and interrupted sitting. Participants completed two sessions in random order: prolonged sitting (4 hours of sitting) and interrupted sitting (prolonged sitting interrupted every 30 minutes by 3 minutes of …

    uoit Repository record

  7. The Immune Modulatory Effects of Tylvalosin in Porcine Neutrophils and Macrophages in vitro

    Moges, RuthGraduate Studies2017

    … (LTB4) and in stimulated macrophages (CXCL8 and IL-1α). Together, these findings demonstrate that tylvalosin has immuno- modulating properties in vitro, including the induction of leukocyte apoptosis, the inhibition of pro-inflammatory cytokines and lipids mediators, and the induction …

    calgary Repository record

  8. Human neutrophils generate extracellular vesicles that modulate their functional responses

    Hurtado Gutierrez, Maria JoséUniversité de Sherbrooke2023

    … G-CSF, IFNγ, and dexamethasone was reversed; CXCL8 and NET formation were induced in otherwise unstimulated neutrophils; the induction of inflammatory chemokines by TNFα was modulated depending on the activation state of the NDEs’ parent cells; and inducible NET generation was attenuated. Our …

    sherbrooke Repository record

  9. Investigation of chemokine expression and modulation following traumatic brain injury

    Rhodes, Jonathan K.J.The University of Edinburgh2010

    … human neutrophil chemokine, interleukin-8 (IL-8/CXCL8; a functional homologue of MIP-2/CXCL2), MCP-1/CCL2 and soluble interleukin-6 receptor (sIL-6R) to contusion enlargement has not been investigated. In this thesis, I investigated chemokine expression and modulation both in in-vitro, in-vivo …

    edinburgh Repository record

  10. O papel das quimiocinas na resposta imune de pacientes com leishmaniose mucosa

    Macedo, Aécio Mateus deFaculdade de Medicina da Bahia2014

    … quimocinas em seus resumos. A produção de CCL2 e CXCL8 por macrófagos de pacientes com LM foi maior do que a produção de pacientes SC. Os níveis de CXCL9 foram significativamente maiores em paciente com LM comparados com paciente SC e grupo controle. De acordo com resultados preliminares …

    brazil-ufba Repository record

  11. Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism

    Ballendine, StephanieUniversity of Saskatchewan2014

    … were also treated with the three injections of CXCL8(3–72)K11R/G31P (G31P) (500 µg/kg, i.p.), a chemokine receptor antagonist that binds CXCR1 and CXCR2 with high affinity. PolyI:C treatment significantly increased maternal levels of the chemokine CXCL1, the rodent analogue of IL-8 that binds …

    sask Repository record

  12. Characterization and Immunomodulatory Function of Human Mesencymal Stem Cells

    장, 인근2011

    … 성장인자를 분석한 결과, 전체적으로 비슷하였으나, IL-12(p40), CCL5, CXCL8 PDGF-AA, VEGF의 분비가 다르게 나타났다. 중간엽줄기세포 자체는 면역반응을 유도하지 않았으며, 동종 말초혈액단핵구나 PHA를 이용한 면역세포 자극시 중간엽줄기세포의 양이 많을수록 면역억제반응이 강하게 나타났고, 면역 반응시 배양 배지내의 IFN-γ와 TNF-α의 양도 시간에 따라 중간엽줄기세포가 없는 대조군에 비해 증가폭이 감소하였다. 또한 transwell system을 이용하여 soluble factor가 면역억제에 …

    ajou Repository record

  13. The role of chemokine receptor trafficking in regulating neutrophil migration to inflammatory sites

    Coombs, Caroline GiseleUniversity of Cambridge2020

    … Here, I address this question using zebrafish Cxcl8a (a homologue of human CXCL8) which signals through two G-protein coupled receptors, Cxcr1 and Cxcr2. Through new in vivo biosensors, I show that Cxcr1 and Cxcr2 exhibit differential trafficking in response to endogenous gradients. Cxcr1 is …

    cambridge Repository record

  14. Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies

    Coish, JeremiaBrock University2025

    … Increases in TNF, IL-1b, CCL5, CCL4, CCL3, CXCL8, CXCL10 were detected in cell-free supernatants 72 hpi for both canonical and ADE replication pathways, albeit ADE significantly increased mediator secretion kinetics as early as 48 hpi. This is the first work characterizing ZIKV infection in …

    brock Repository record

  15. Innate Immunity in Chickens: In Vivo Responses to Different Pathogen Associated Molecular Patterns

    Byrne, Kristen Alicia2017

    … mRNA expression of IL-1, IL-6, IL-10, and CXCL8, and at lower expression levels IL-4 and IFN. As the first comprehensive investigation into the immunostimulatory effects of PAMPs in a complex tissue, we show that intradermal administration of PAMPs initiates an elaborate cascade of …

    arkansas Repository record

  16. Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)

    khalifah, Afnan2025

    … proinflammatory cytokines (CCL11, CCL19, CD8A, CXCL8, and FGF-19) in serum and (CSF3 and IL-1β) in gingival crevicular fluid (GCF). Race- and sex-stratified analyses demonstrated unique cytokine profiles, with elevated levels of CCL23, CXCL5, FGF5, and DNER in individuals of African ancestry, …

    penn Repository record

  17. Investigating the role of IgG and Fcγ receptors in intestinal inflammation

    Castro Dopico, TomasUniversity of Cambridge2018

    … associated with UC susceptibility, were IL1B andCXCL8. Ex vivo stimulation of human and murine lamina propria mononuclear cells with IgG immune complexes (IC) resulted in an increase in these cytokines/chemokines. In vivo manipulation of the macrophage FcγR A/I ratio in transgenic mice determined …

    cambridge Repository record

  18. Analisi dell espressione delle Chitinasi e dei geni ad esse correlati nei soggetti esposti ad agenti inquinanti e al fumo di sigaretta

    LONGO, ANNA MARIAUniversità degli studi di Catania2017

    … IL1b, IL6, CCL2, CXCL5, CXCL1, CXCL3, CXCL6, CXCL8, CXCL2) coinvolte nei processi infiammatori. Alcuni dati di questo studio sono stati acquisiti utilizzando un dataset di microarray costituito dal trascrittoma di macrofagi alveolari di soggetti fumatori e controlli non fumatori. Risultati L …

    catania Repository record

  19. Maternal Immune Markers In Serum During Late Gestation and In Breast Milk and the Risk of Asthma-Like Symptoms At Ages 6 and 12 Months: A Longitudinal Study

    Soto-Ramírez, Nelís Del Carmen

    … interleukin (IL) 1-beta;, IL-4, IL-5, IL-6, CXCL8, IL-10, IL-12(p70), IL-13, transforming growth factor (TGF)-beta-1, and immunoglobulin (Ig) A in both maternal serum and milk whey were determined via immunoassays. FAs concentrations of n-3 and n-6 were determined by gas chromatography. AS of …

    south-carolina Repository record

  20. Determining the contribution of formylated peptides and formyl peptide receptor 1 to the pathogenesis of acute lung injury

    Dorward, David AndrewThe University of Edinburgh2014

    … release of the neutrophil chemo-attractant mouse CXCL8 (KC). Conclusions: Taken together, mitochondrial formylated peptides released following cell necrosis and FPR1 play a significant role in the pathogenesis of sterile acute lung injury. This is likely to be predominantly through …

    edinburgh Repository record