Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"CXCL5"”.
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MUTANT P53 REGULATION OF CXC-CHEMOKINE EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA
… pathways function to increase the expression of CXCL5, which has been identified as a key mediator in the process of tumor metastasis. Previous data from our lab suggested that the p53 homolog, p63, may function as a negative regulator of CXCL5 and that mutant p53 may inhibit this molecule to …
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The Effects of Gain of Function Mutant p53 and p63 on EPS8 and CXCL5 Expression in Head and Neck Squamous Cell Carcinoma
… mutant p53 enhances, and p63 inhibits, EPS8 and CXCL5 expression and promoter activity. We found decreased EPS8 expression, CXCL5 expression, and cellular migration associated with the loss of GOF mutant p53. This indicates an enhancing role of GOF mutant p53 in cellular migration and expression …
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P53 mediated cell motility in H1299 lung cancer cells
… cell motility were determined by scratch assays. CXCL5- chemokine is also known to induce cell motility. We hypothesized that enhanced cell motility by AKT and NFκB is mediated, in part, by CXCL5. CXCL5 expression levels in the presence and absence of inhibitors were determined by qRT-PCR. We also …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… promotes proliferation, and upregulates CXCL5</p> <p>which recruits macrophages into the tumor microenvironment (TME). These</p> <p>tumor-associated macrophages not only suppress anti-tumor immunity but</p> <p>serve to support cancer cell survival via their secretion of GAS6 which</p> …
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
… we found that at the gene expression level, <em>CXCL5</em>, a CXCR2-ligand, was the main driver of a cluster of cell lines and lung adenocarcinomas with high-risk features, including <em>RAS</em> and MET pathway activation, epithelial-to-mesenchimal transition and resistance to epidermal growth …
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Decoding Disease Drivers Through Single-Cell Omics and Scalable Phenotypic Screens
… de novo gene program highly enriched in the MMP1+CXCL5+ Fibroblast that correlates with TB burden in a non-human primates (NHP) granuloma dataset, supporting the importance of this subset in TB. In a collaborative effort, we validate that this MMP1+CXCL5+ Fibroblast localizes to TB granuloma on …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… including chemokines CCL20, CXCL3, CX3CL1, CXCL5, CXCL2 and CXCL1, the receptors Tenascin C, OLR1, IL-18 receptor 1 and growth factors, CSF2, CSF3, IL-6, IL1 and FGF18. Downregulated genes were transcription factors/signaling molecules including ID2. Microarray results were confirmed for …
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Investigating the role of primary cilia loss in intrahepatic cholangiocarcinoma
… chemokines such as Cxcl1, Cxcl2 and Cxcl5 was significantly suppressed. In concordance, immunohistochemical analysis revealed that neutrophil infiltration was frequently decreased in the livers of mice with non-ciliated biliary cells when compared to mice with ciliated cholangiocytes. …
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Investigating The link Between High-Risk Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Haplotypes, Periodontal Inflammation and Depression in People With HIV (PWH) on Antiretroviral Therapy ( ART)
… profiles, with elevated levels of CCL23, CXCL5, FGF5, and DNER in individuals of African ancestry, and increased IL-4 and MMP-10 in individuals of White origin, underlining ancestry-dependent immune regulation. Moreover, to clarify the cellular mechanisms linking PERK signaling to …
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Analisi dell espressione delle Chitinasi e dei geni ad esse correlati nei soggetti esposti ad agenti inquinanti e al fumo di sigaretta
… CHID1) e delle citochine (TNFa, IL1b, IL6, CCL2, CXCL5, CXCL1, CXCL3, CXCL6, CXCL8, CXCL2) coinvolte nei processi infiammatori. Alcuni dati di questo studio sono stati acquisiti utilizzando un dataset di microarray costituito dal trascrittoma di macrofagi alveolari di soggetti fumatori e controlli …
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Identification of Subclass-Specific Biomarkers by Developing an Integrated Database of Breast Cancer
… related genes including MMP12 and BCL2A1, CXCL5 are observed. On the other hand, FOS, which known as oncogenes, and TFF2, which is known to induce endocervicitis that closely associated to breast disease, are underexpreseed. To check the classification accuracy of these genes, we use four …
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Inhibitory potential of anthocyanins and anthocyanin-rich extracts on colorectal cancer progression through apoptosis, angiogenesis, and immune response effects
… modified (Secreted phosphoprotein 1 and CXCL2, CXCL5, and CXCL10). Black lentil and D3G-enriched extracts impacted interleukin-17 signaling, cytokine-cytokine receptor interaction, and intestinal immune network pathways. Black lentil treatment showed both anti-carcinogenic and anti-inflammatory …