Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 19 of 19 for “"CXCL2"”.
-
Stat3 Controls The Neutrophil Migratory Response to Cxcr2 and Its Ligand Mip-2 (Cxcl2)
… unknown. The chemokines KC (Cxcl1) and MIP-2 (Cxcl2), and their shared receptor CXCR2 (l8rb), also stimulate neutrophil mobilization, in contrast to SDF-1 (Cxcl12), which contributes to neutrophil retention in the bone marrow, requiring downregulation to promote neutrophil release. Using a …
-
Investigation of chemokine expression and modulation following traumatic brain injury
… macrophage inflammatory protein-2 (MIP-2/CXCL2) and the monocytic chemokine, monocyte chemoattractant protein-1 (MCP-1/CCL2) are derived from glial. However the origin of these chemokines following TBI, has not been established. Furthermore, little is known about the modulation of these …
-
Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin
… on two adipocyte-supplied chemokines, CXCL1 and CXCL2, and bone marrow macrophage-secreted osteopontin as key drivers of pro-inflammatory environment in the bone marrow and important regulators of tumor growth and survival in bone. </p> <p>Our results revealed that adipocyte-supplied CXCL1 and …
-
Isoprenylation and NET formation in acute pancreatitis
… reduction of neutrophil up-regulation Mac-1 and CXCL2 formation in the pancreas. Blocking geranylgeranyltransferase activity attenuated systemic inflammation and pulmonary neutrophils in animals with pancreatitis. In paper Paper III address the role of Ras-signalling in AP. Ras inhibition …
-
Rac1 signaling regulates platelet-dependent inflammation abdominal sepsis
… macrophages leading to local secretion of CXCL2. Thus, our novel data not only elucidates complex mechanisms regulating pulmonary neutrophil trafficking in sepsis but also suggest that targeting Rac1 signaling and platelet-derived CCL5 might be a useful way to control pathological …
-
Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… chemokines CCL20, CXCL3, CX3CL1, CXCL5, CXCL2 and CXCL1, the receptors Tenascin C, OLR1, IL-18 receptor 1 and growth factors, CSF2, CSF3, IL-6, IL1 and FGF18. Downregulated genes were transcription factors/signaling molecules including ID2. Microarray results were confirmed for selected …
-
ROLES OF MAST CELL G PROTEIN-COUPLED RECEPTOR KINASE 2 (GRK2) IN ALLERGY AND INFLAMMATION
… of matrix metalloproteinase 9 (MMP9), chemokine, CXCL2, and the recruitment of MCs and inflammatory cells in control mice but these responses were substantially reduced in GRK2-deleted mice. IgE-mediated anaphylaxis and itch were also significantly reduced in the absence of GRK2. Furthermore, in …
-
Regulation Of Neutrophil Homeostasis By Chemokines Signaling Through The Cxcr2 And Cxcr4 Receptors
… granulocyte colony stimulating factor: G-CSF), CXCL2, or Listeria monocytogenes infection are absent or impaired in CXCR4-/- neutrophils, suggesting that disruption of CXCR4 signaling may be a common step mediating neutrophil release. CXCR2-/- neutrophils exhibit abnormal retention in the bone …
-
Sustained Adrenergic Signaling Promotes Cervical Cancer Progression
… and elevated mRNA of pro-inflammatory genes CXCL2 and IL-8. Further, the fibroblasts took up cervical cancer cell derived exosomes that contain HPV E7. The conditioned fibroblasts demonstrated the ability to increase cervical cancer cell invasion when co-cultured.</p> <p>Conclusion:<strong> …
-
Les Récepteurs nicotiniques de l'acétylcholine modulent la production et la distribution des monocytes pro-inflammatoires
… les monocytes (CCL2) et les neutrophiles (CXCL2), dans le cerveau de souris EAE. Cependant, deux autre facteurs pourraient aussi y contributer : la réduction du nombre de monocytes M1 dans le sang et la réduction de la capacité des monocytes à répondre au CCL2. En résumé, cette …
-
Investigating the role of primary cilia loss in intrahepatic cholangiocarcinoma
… of neutrophil-specific chemokines such as Cxcl1, Cxcl2 and Cxcl5 was significantly suppressed. In concordance, immunohistochemical analysis revealed that neutrophil infiltration was frequently decreased in the livers of mice with non-ciliated biliary cells when compared to mice with ciliated …
-
The Role and Regulation of Id2 In Dendritic Cells
… specific roles for Id2 to modestly promote CXCL2 production from CD103<sup>+</sup> cDC1s, though Id2 was largely dispensable for their maturation. Collectively, we conclude Id2 predominately exerts its role as a developmental regulator of the cDC1 lineage, but also regulates the production …
-
Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… Chemokine levels of CCL2, CCL3, CCL4, CXCL1, CXCL2, and CXCL10 were also lowered. Neutrophilic alveolitis was decreased, as was granuloma formation and fibrosis over longer exposure periods. Minor alterations in B cell populations and levels of immunoglobulin subtypes were altered, with …
-
The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
… bacterial count, neutrophil infiltration and CXCL2 expression. In addition, ATF3-null mice displayed compromised flagellin-induced corneal protection compared to PBS-pretreated ATF3-/- littermates at 3 dpi. Together, our results indicate that ATF3 plays a role in the corneal innate immune …
-
Toll-like Receptors 2 and 9 Are Important for Innate Immune Cell Activation and Recruitment in Hypersensitivity Pneumonitis
… in the expression of the neutrophil chemokine CXCL2 and inflammatory cytokines TNFα and IL-6 in the BALF. Disease severity in HP is associated with granuloma formation and a Th17 response. After 3 weeks exposure to SR, our results demonstrate a decrease in IL-17 and IL-22 mRNA expression and a …
-
DISSECTING THE ROLE OF THE TETRASPANIN MS4A4A IN MODULATING MACROPHAGE PLASTICITY AND FUNCTION
… by affecting the release of TNF-α and CXCL2. This modulatory role of MS4A4A appears to be independent on direct influence on FcγR signaling, and the precise mechanism remains to be defined. To dissect the role of MS4A4A in macrophage activation mediated by TLR-2, we found that MS4A4A …
-
Analisi dell espressione delle Chitinasi e dei geni ad esse correlati nei soggetti esposti ad agenti inquinanti e al fumo di sigaretta
… IL6, CCL2, CXCL5, CXCL1, CXCL3, CXCL6, CXCL8, CXCL2) coinvolte nei processi infiammatori. Alcuni dati di questo studio sono stati acquisiti utilizzando un dataset di microarray costituito dal trascrittoma di macrofagi alveolari di soggetti fumatori e controlli non fumatori. Risultati L analisi …
-
Uncovering the hidden mechanisms governing the transcriptional regulation of inflammation
… ELR+ CXCL chemokines (IL-8, CXCL1, CXCL2 and CXCL3). By exploiting the pre-formed local 3D topology, UMLILO is able to epigenetically prime the chemokines for transcriptional activation. This involves the discrete deposition of H3K4me3 onto the promoters of the chemokines, which …
-
Inhibitory potential of anthocyanins and anthocyanin-rich extracts on colorectal cancer progression through apoptosis, angiogenesis, and immune response effects
… modified (Secreted phosphoprotein 1 and CXCL2, CXCL5, and CXCL10). Black lentil and D3G-enriched extracts impacted interleukin-17 signaling, cytokine-cytokine receptor interaction, and intestinal immune network pathways. Black lentil treatment showed both anti-carcinogenic and …