Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 44 for “"CXCL12"”.
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The roles of the chemokines CXCL12 and CXCL16 in breast cancer.
… immunity. Evidence suggests that the chemokine CXCL12 and its receptors may be important in a number of aspects of breast cancer progression and site-specific metastasis. Another chemokine, CXCL16, has been identified as a specific chemotactic factor for Type Ipolarised T lymphocytes, which are …
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CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse
… has been reported. The chemokine CXCL12 is constitutively expressed in adult brain and expression of CXCL12 and its cognate receptor CXCR4 have been reported in regions of rat brain that construct dopamine (DA) and glutamate (GLU) pathways such as ventral tegmental area (VTA), …
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Stromal cell derived factor-1/CXCL12 acts as a hematopoietic progenitor cell survival factor by reducing apoptosis
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Die Bedeutung der Interaktion des Chemokins SDF-1 (CXCL12) mit CXCR4-Chemokinrezeptoren auf Leukämiezellen von Patienten mit Akuter Myeloischer Leukämie
KM - Stromazellen regulieren die Entwicklung und Proliferation HSC innerhalb des KM - Mikromilieus. Die AML stellt eine Neoplasie unreifer hämatopoetischer Zellen dar, durch die Verdrängung der gesunden Hämatopoese durch Blasten sind Teile des klinischen Erscheinungsbilds <br> der Erkrankung zu …
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Il nucleotide extracellulare UTP: induzione della migrazione di cellule staminali emopoietiche CD34+
… di promuovere, in associazione alla chemochina CXCL12, la migrazione di cellule staminali umane CD34+. E’ così emerso che la stimolazione con UTP è in grado di incrementare significativamente la migrazione dei progenitori emopoietici in risposta al gradiente chemioattrattivo di CXCL12, nonché la …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… populations. Tumour cells expressed CXCL10, CXCL12 and CCL21. Vessels expressed ICAM-1, CXCL12, CCL17 and CCL21. Tumour cell lines secreted factors that mediated chemotaxis of lymphoblasts in vitro and TIL demonstrated chemotaxis to CXCL12 but not CCL17. VAP-1 was expressed on vessels and a …
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Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma
… and this effect is related to the chemokine CXCL12 produced by FAP+ stromal cells. Targeting the CXCL12/CXCR4 pathway with AMD3100, a CXCR4 antagonist, resulted T cell infiltration and tumor regression with anti-PD-L1 therapy in the KPC model. The CAMPLEX clinical trial was initiated to …
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The Hematopoietic Compartment Regulates Osteoblast Differentiation And Apoptosis During Cytokine Treatment
… the disruption by G-CSF of signaling between CXCL12, a chemokine expressed in the HSC microenvironment, and its receptor CXCR4, broadly expressed on hematopoietic cells. By examining mice genetically deficient in CXCR4, we show that this mechanism is not only the predominant pathway by which …
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Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury
… not upregulate adhesion molecule expression but CXCL12 and CXCL1 did significantly enhance HSC adhesion to endothelium. However, blockade of CXCR4 (CXCL12 receptor) failed to reduce HSC adhesion in vivo following IR injury. Furthermore, we demonstrated exogenous HSCs were identified primarily in …
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B-RafV600E에 의한 갑상샘 발암과정에서 Thyroid stimulating hormone (TSH) 의 역할연구
… cancer cell invasion by means of the CXCR4 and CXCL12 interaction. 57 11. CXCR4 expression is correlated with CXCL12 level and invasion ability. 62 IV. DISCUSSION 70 V. CONCLUSION 79 VI. REFERENCES 80 국문요약 88
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The roles of human cytomegalovirus US27 gene product during virus infection
… of CXCR4 in response to its natural ligand CXCL12. cmvIL-10, an ortholog of human IL-10, was also found to enhance CXCR4 signaling and act synergistically with US27. In both HCMV-infected and US27-transfected cells, exposure to cmvIL-10 increased calcium and migration responses to CXCR4 …
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Développement et caractérisation de ligands du récepteur à chimiokine CXCR4
… couplés aux protéines G les plus étudiés. Le CXCL12, sa chimiokine endogène induit l’activation de plusieurs voies de signalisation cruciales à plusieurs processus physiologiques. Par ailleurs, dans de nombreux processus pathologiques comme le cancer, le récepteur CXCR4 et/ou son ligand …
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Vitamin D Levels Affect Survival in a BCR-ABL Acute Lymphoblastic Leukemia Mouse Model but Do Not Cause Vitamin-Drug Interactions
… with bone marrow stroma. 1, 25-(OH)2VD3 induced CXCL12 production in vivo and in vitro in bone marrow stromal cells and CXCL12 increased stromal migration and the number of BCR-ABL blasts. Vitamin D together with ALL reprogrammed the marrow environment by increasing production of Type I and V …
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Estudio de la influencia de los fibroblastos del estroma tumoral en el comportamiento de los carcinomas mamarios
… inflamatorias (IL6 y IL8), quimiocinas (CCL2 y CXCL12), proteasas (uPA, MMP2, MMP9 y MMP11), el factor de transcripción NF¿B y TIMP1. También se analizó mediante cocultivos de los CAFs con dos líneas celulares de cáncer de mama (MCF7 y MDA-MB-231), la posible existencia de una influencia …
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Examining Cellular Interactions and Response to Chemotherapy in The Glioblastoma Perivascular Niche
… 68%, as well as elevated secretion of TGF-β and CXCL12 up to 2.6-fold from Day 8 to 14. These trends correlated with cell colocalization, indicating a chemotactic role for CXCL12 in enabling the migration of LN229 cells towards HUVECs in co-cultures. Von Willebrand factor (vWF) was co-expressed …
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Stat3 Controls The Neutrophil Migratory Response to Cxcr2 and Its Ligand Mip-2 (Cxcl2)
… neutrophil mobilization, in contrast to SDF-1 (Cxcl12), which contributes to neutrophil retention in the bone marrow, requiring downregulation to promote neutrophil release. Using a murine model with conditional STAT3 deletion in bone marrow, we demonstrate that STAT3 regulates G-CSF-dependent …
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Conformational engineering of human chemokine receptors and HIV-1 Env using deep mutational scanning
… landscapes, I identified that the chemokine CXCL12 binds asymmetrically in the CXCR4 ligand-binding cavity, discovered mutations within a potential allosteric site in CXCR4 that enhance CXCL12 binding, and engineered a CCR5 variant with increased Env binding for structural biology purposes. …
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Graphene-based Biochemical Sensing Array: Materials, System Design and Data Processing
… nature-like specific interactions with the CXCL12 ligand and HIV-coat glycoprotein in 100% human serum. Furthermore, the platform is capable of providing highly distinguishable fingerprints of relevant biomarkers in breath. Machine learning models trained on multi-dimensional data collected …
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Development of an Injectable Hydrogel Platform to Capture and Eradicate Glioblastoma Cells with Chemical and Physical Stimuli
… and entrapping GBM/GSCs into the hydrogel with CXCL12-mediated chemotaxis, and 3) assessing the feasibility of utilizing histotripsy to mechanically and non-invasively ablate cells entrapped in the hydrogel. The results revealed that hydrogel formulations comprising 0.175 M NaHCO3(aq) and 50 wt% …
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