Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 52 for “"CXCL10"”.
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Enzymatic cleavage of chemokines CCL2 and CXCL10 : Implications for multiple sclerosis pathogenesis.
… type in the CNS, and endothelial cells. CCL2 and CXCL10 are chemokines expressed in MS lesions, which are thought to be pivotal in chemoattraction of T cells and monocytes into the CNS. Astrocytes, microglia, and endothelial cells produce proteases, such as matrix metalloproteinases (MMPs), which …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… United States. The pro-inflammatory chemokine CXCL10 is induced by hepatitis C virus (HCV) infection <italic>in vitro</italic> and <italic>in vivo</italic>, and is associated with the outcome of interferon (IFN)-based therapies. Since persistent hepatic inflammation can lead to degenerative …
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Characterization of the effects of Interferon gamma protein-10 (CXCL10) against the protozoan parasite Leishmania amazonesis
… of the infection. In this study, we found that CXCL10-treated bone marrow-derived macrophages from both BALB/c and C57BL/6 mice showed decreased numbers of L. amazonensis parasites, which was partially due to increased nitric oxide production, as well as elevated production of pro-inflammatory …
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Neuropathological characterization of transgenic mice with astrocyte-directed production of the CXC chemokine ligand 10
… disorders. In the present study, the impact of CXCL10 production in the CNS was examined in transgenic mice with astrocyte-directed production of this chemokine. <br>These glial fibrillary acidic protein (GFAP)-CXCL10 transgenic mice developed spontaneous, transgene dose- and age-related …
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The Transcriptional Regulation Of Flagellin-Induced Innate Protection Of The Cornea: Role Of Irf1 And Atf3
… siRNA and identified the pleiotropic chemokine CXCL10, but not IL12-p35 or iNOS, as a specific target. </p> <p>We then attempted to understand the role of IRF1 and CXCL10 in mucosal innate protection against infections in vivo. Flagellin augmented the P. aeruginosa-induced expression of CXCL10 …
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Die Bedeutung von Entzündung und reaktiven Sauerstoffspezies in der Intimahyperplasie
… Chemokine CXCL9 (MIG, Monokine Induced by INF), CXCL10 (IP-10, INF inducible Protein of 10 kDa) und CXCL11 (I-TAC, Interferon inducible T cell-Chemoattractant) induziert. CXCL9, CXCL10 und CXCL11 sind Liganden des CXC-Chemokinrezeptors 3 (CXCR3) und locken chemotaktisch CXCR3 positive …
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Microglial Modulation of Neuronal Autophagy: Uncovering Cytokine-Mediated Pathways
… receptor-ligand pairs, CXCR5-CXCL13 and CXCR3-CXCL10, were identified as inducers of autophagy. CXCL13, the ligand for CXCR5, enhanced autophagy in several neuronal models, including primary mouse neurons and iPSC-derived neurons. Similarly, CXCL10 promoted autophagy in SH-SY5Y cell line and …
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Cytokines regulation of chemokine and chemokine receptor in relation to multiple sclerosis.
Expression of chemokines CXCL10 and CCL2 is elevated within inflammatory lesions in the central nervous system (CNS) of multiple sclerosis (MS) patients, particularly in astrocytes. These chemokines play a critical role in the recruitment of inflammatory cells into the CNS during inflammation. …
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Effects of β-funaltrexamine on lipopolysaccharide-induced inflammation and behavior
… and spleen tissues were harvested. CCL2, CXCL10, and IL-1β levels were measured in cell supernatant, CCL2 and CXCL10 were measured in frontal cortex, hippocampus, and spleen tissues, and IL-1β and corticosterone were measured in mouse plasma via ELISA. IDO1 and NLRP3 transcription were …
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Characterization of pro- and anti-inflammatory immune responses in SARS-CoV-2 infection
… COVID-19 patients is C-X-C motif chemokine 10 (CXCL10), which has been explored as a prognostic marker as it is shown to be predictive of disease outcome in hospitalized patients. To prevent severe outcomes like cytokine storm, a delicate balance must be struck, to ensure that this inflammation …
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O papel das quimiocinas na resposta imune de pacientes com leishmaniose mucosa
… significativamente mais elevados de CCL4 e CXCL10 em amostras de soro de pacientes com LM em comparação a pacientes com LC e grupo controle. Discussão: As diferentes quimiocinas interferem de diversas formas na multiplicação do parasita, sendo assim, agem de maneiras diferentes na inflamação …
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Ecology of Hantaviruses in Rodent Reservoirs and Their Early Innate Immune Responses in Human Model Systems
… analysis revealed the mRNA levels of only CCL5, CXCL10, CXCL11, IDO1, IFNB1, IRF7, and TLR3 we increased during infection of each viruses. The measurement of CCL5, CXCL10, CXCL11, IDO, and IFN-β secreted protein levels in the same HLMVEC donor during infection confirmed gene expression findings. …
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Mutations In Stat3 Associated With Human Hyper Ige Syndrome Enhance Nfκb and Mapk-Mediated Gene Expression
… expression of the NFκB target genes IL6 (IL-6), Cxcl10 (IP- 10), and Tnf (TNFα) in RAW cells, as indicated by qPCR. Furthermore, overexpression of wild type STAT3 in Stat3-deficient murine embryonic fibroblasts significantlyreduced LPS-stimulated expression of IL6, Cxcl10, and IL12p35. In …
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Molecular and Cellular Mechanisms of the Angiogenic Effect of Poly(methacrylic acid-co-methyl methacrylate) Beads
… TNF-α and Spry2, but decreased the expression of CXCL10 and CXCL12, compared to PMMA and no beads. MAA beads also appeared to modulate the expression of OPN. In vivo, the global gene expression of OPN was increased in wounds treated with MAA beads, compared to PMMA and no beads. In contrast, …
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Characterizing Zika and West Nile virus infection in mast cells and the antibody-dependent enhancement potential mediated by dengue virus antibodies
… of ZIKV by D11C was coupled to CCL5, IL-1b, and CXCL10 mediator release. Surface FcγRII was essential for both ZIKV and WNV ADE in mast cells since blocking the receptor-antigen interaction diminished both viral replication and immune mediator release. KU812 cells were exceptionally permissive to …
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Loss of Ptdss1 in tumor cells improves anti-PD-1 therapy
… of IFNγ-regulated genes, including B2m, Cxcl9, Cxcl10, and Stat1. Loss of PTDSS1 in tumor cells also led to increased expression of MHC-I, which was associated with increased expression of cytolytic function related genes in CD8<sup>+</sup> T cells and increased frequency of an iNOS<sup>+</sup> …
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The role of DNA damage associated microRNAs in enhancing the chemotherapeutic responses in triple negative breast cancer (TNBC)
… associated with concurrent increases in IL-6 and CXCL10 levels (p < 0.01 and p< 0.001 respectively). Meanwhile, these low dose radiation effects were associatedwith a reduction in miR-21 levels (p < 0.05). To verify this association, the miR-21 expression was inhibited using an anti-miR-21 …
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Pharmacological studies of bioactive compounds from medicinal mushrooms in Northeast of Thailand
… at 150 μg/ml for P and E. All six genes (Ccl2, Cxcl10, Cxcl13, Tnfsf10, Il6, and Tnf-α) showed downregulation in all samples. RNA-Seq of P and E showed the cytokine-cytokine receptor interaction pathway was affected in almost all treatment samples. RT-qPCR showed that TNFα, IL6 and CCL2 were …
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The Role of Human Guanylate Binding Proteins in Host Defense and Inflammation
… of several chemokines, including CXCL1, CXCL9, CXCL10, and CCL2, which act as chemoattractants for professional immune cells. This role in chemokine expression was independent of the GBP1 PBM and CaaX motif necessary for bacterial targeting, and extended not only to B. thailandensis, but also L. …
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Molecular mechanisms of T cell homing in Hodgkin's lymphoma : implications for T-cell-based therapies
… on minor populations. Tumour cells expressed CXCL10, CXCL12 and CCL21. Vessels expressed ICAM-1, CXCL12, CCL17 and CCL21. Tumour cell lines secreted factors that mediated chemotaxis of lymphoblasts in vitro and TIL demonstrated chemotaxis to CXCL12 but not CCL17. VAP-1 was expressed on vessels …
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