Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"CXCL1"”.
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Suppression of LPS-induced cytokines/chemokines production by CXCL1 siRNA
… via factors such as NF-κB, TNF-α, IL-1β, and CXCL1. Down -regulation of these inflammatory mediators induced by periodontal bacteria through inhibitors may result in inhibition or resolution of inflammation and subsequent disease. Preliminary data indicated that Porphyromonas gingivalis (P. …
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The recruitment of stromal cells to the site of tumor formation
… carcinoma model, termed BPLER, we identified CXCL1, VEGF, CCL5, and IL-6 as factors that may be important for the recruitment of myofibroblasts. We tested the ability of CXCL1, VEGF164, or CCL5 to affect tumor formation and induce the incorporation of a-SMApositive cells. We show that the …
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Adipocyte-Induced Inflammation In Prostate Tumor Progression In Bone: Role Of Cxcr2 And Osteopontin
… focused on two adipocyte-supplied chemokines, CXCL1 and CXCL2, and bone marrow macrophage-secreted osteopontin as key drivers of pro-inflammatory environment in the bone marrow and important regulators of tumor growth and survival in bone. </p> <p>Our results revealed that adipocyte-supplied …
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Stat3 Controls The Neutrophil Migratory Response to Cxcr2 and Its Ligand Mip-2 (Cxcl2)
… the mechanism was unknown. The chemokines KC (Cxcl1) and MIP-2 (Cxcl2), and their shared receptor CXCR2 (l8rb), also stimulate neutrophil mobilization, in contrast to SDF-1 (Cxcl12), which contributes to neutrophil retention in the bone marrow, requiring downregulation to promote neutrophil …
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The effect of gender on Helicobacter pylori and gastric cancer
… associated with cellular movement and cancer. CXCL1, a murine homolog of IL-8, was downregulated by treatment at both local and systemic levels, which led to a decreased neutrophilic infiltrate. 17[beta]-estradiol and Tamoxifen mediated the disruption of a positive feedback loop coupling CXCL1 …
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Molecular events governing hematopoietic stem cell recruitment in Vivo in murine liver following Ischemia-reperfusion injury
… not upregulate adhesion molecule expression but CXCL12 and CXCL1 did significantly enhance HSC adhesion to endothelium. However, blockade of CXCR4 (CXCL12 receptor) failed to reduce HSC adhesion in vivo following IR injury. Furthermore, we demonstrated exogenous HSCs were identified primarily in …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… increased maternal levels of the chemokine CXCL1, the rodent analogue of IL-8 that binds CXCR1 and CXCR2. The offspring of polyI:C-treated dams showed impaired associative recognition memory and multisensory integration, as well as subtle impairments in prepulse inhibition (PPI). G31P …
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Development of an inhaled liposomal-loaded azithromycin formulation for the treatment of chronic respiratory infection
… in a decrease in pro-inflammatory cytokine CXCL1 from a lipopolysaccharide stimulated murine alveolar macrophage cell line in vitro. Finally, the adjustment of protectant sugar to a mixture of trehalose and dextran offered further improvements in glass transition temperature and water …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… of pro-inflammatory cytokines such as Il1β, Cxcl1, and Ccl2. This animal model was thus validated in studying colitis progression and highlighted the potential of dietary interventions, such as the modified (MOD) diet, to alleviate inflammation. Subsequent research focused on tuft cells, …
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BREAST CANCER DURING PREGNANCY AS A SPECIAL TYPE OF EARLY-ONSET BREAST CANCER: INSIGHTS INTO THE TUMOR MICROENVIRONMENT AND IMMUNE TRANSCRIPTOME
… PrBCT-specific, one (PECAM1) upregulated and 3 (CXCL1, CCL21, and HGF) downregulated. The TME and immune transcriptome of PrBC are characterized by specific patterns of TIL subpopulations and distinct gene expression patterns. Assessment of TILs and TILs subtyping in these patients might help to …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… CCL20, CXCL3, CX3CL1, CXCL5, CXCL2 and CXCL1, the receptors Tenascin C, OLR1, IL-18 receptor 1 and growth factors, CSF2, CSF3, IL-6, IL1 and FGF18. Downregulated genes were transcription factors/signaling molecules including ID2. Microarray results were confirmed for selected genes …
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M2 Polarization and Pro-Fibrotic Transition of Lupus Nephritis Macrophages
… Th2-associated mediators, including CXCL1, CCL11, IL-6, IL-9, and TSLP, in shaping macrophage function within the LN microenvironment. To determine whether macrophages contribute directly to fibrosis, we examined the effects of TGF-β and LN patient serum on macrophage reprogramming. …
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The Recruitment and Function of Tumor Microenvironment Components During Gastric Carcinogenesis
… in both models, namely IL-6, IL-1β, and CXCL1. While H. felis infection had no effect on the phenotype of K19kras mice, epidemiological studies have shown that in humans, obesity increases one's risk of a wide variety of cancers, including gastric cancer, and indeed, we noted a synergy …
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Investigating the Role of Trimeric Autotransporter Adhesins in Fusobacterium nucleatum Pathogenesis
… the bacterium also promotes the secretion of CXCL1, which is an important signaling protein that promotes tumor metastases. Overall, the work provided in this dissertation has delivered the initial characterization of TAAs in F. nucleatum virulence, a framework for future studies of Type 5c …
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
… mediates signaling by binding to CXC chemokines CXCL1-3 and 5-8. In non-small cell lung cancer CXCR2 has been studied mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. However, there is controversial data in the literature about CXCR2 expression in tumor cells …
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Investigating the role of primary cilia loss in intrahepatic cholangiocarcinoma
… of pro-inflammatory cytokines such as Cxcl9, Cxcl10 and Cxcl11. However, the expression of neutrophil-specific chemokines such as Cxcl1, Cxcl2 and Cxcl5 was significantly suppressed. In concordance, immunohistochemical analysis revealed that neutrophil infiltration was frequently decreased in …
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Pancreatic Cancer: Oncomicrobes, Electric Fields, and Fluid Flow
… profile, characterized by elevated IL-8, CXCL1, MIP-3α, and GM-CSF. F. nucleatum invasion promoted migration and proliferation in Panc1 and BxPC3 cancer cell lines. Conditioned media from infected BxPC3 cells stimulated migration in both uninfected BxPC3 and Panc1 cells, suggesting …
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Decoding novel virulence strategies in Fusobacterium invasion and survival
… in inducing secretions of the cytokines IL-8 and CXCL1 while confirmed the specific association of Fap2 in bacterial-induced cytokine secretion. Thus, our findings provided the first comparative and functional analysis of Fusobacterium type 5a autotransporter proteins in colorectal cancer cells …
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Protein Kinase D1 in Myeloid Cells Promotes Disease Progression and Severity in S. rectivirgula Induced Hypersensitivity Pneumonitis
… and IFNγ. Chemokine levels of CCL2, CCL3, CCL4, CXCL1, CXCL2, and CXCL10 were also lowered. Neutrophilic alveolitis was decreased, as was granuloma formation and fibrosis over longer exposure periods. Minor alterations in B cell populations and levels of immunoglobulin subtypes were altered, with …
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New roles of Rac-GEFs in Neutrophils and in Glucose Homeostasis
… avidity in Tiam1–/– neutrophils stimulated with CXCL1, and increased migration of Tiam1–/– neutrophils under shear stress. These results contribute to our elucidation of the mechanisms underlying the paradoxical increase in the adhesion of Tiam1-deficient neutrophils. In the second part, I …
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