Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"CXC"”.
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The Novel Purification and Biophysical Characterization of CXC Chemokines
… from insulin resistance. In particular, the CXC family of chemokines are active as monomers, homodimers, and heterodimers, with binding affinities for multiple CXC G-protein-coupled receptors. This intricate network has been linked to many cell signaling pathways, but the overall protein …
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MUTANT P53 REGULATION OF CXC-CHEMOKINE EXPRESSION IN HEAD AND NECK SQUAMOUS CELL CARCINOMA
… pathways function to increase the expression of CXCL5, which has been identified as a key mediator in the process of tumor metastasis. Previous data from our lab suggested that the p53 homolog, p63, may function as a negative regulator of CXCL5 and that mutant p53 may inhibit this molecule to …
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Behavioral alterations in rat offspring following maternal immune activation and CXC chemokine receptor antagonism
… were also treated with the three injections of CXCL8(3–72)K11R/G31P (G31P) (500 µg/kg, i.p.), a chemokine receptor antagonist that binds CXCR1 and CXCR2 with high affinity. PolyI:C treatment significantly increased maternal levels of the chemokine CXCL1, the rodent analogue of IL-8 that binds …
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Neuropathological characterization of transgenic mice with astrocyte-directed production of the CXC chemokine ligand 10
… physiological and pathological states. The CXC chemokine ligand (CXCL) 10 (formerly known as IP-10) is induced locally in the central nervous system (CNS) during diverse neuroinflammatory disorders. In the present study, the impact of CXCL10 production in the CNS was examined in transgenic …
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The Interplay of Identity, Culture, School and Mathematics: A Caribbean Perspective
… in the Caribbean Examinations Council (CXC) Secondary Education Certificate (CSEC), examinations taken by students at the end of secondary school. It was thought that a study which looked at students' views of mathematics would get at answers for the perceived underachievement. Implicit …
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Ras Intrinsic and Extrinsic Pathways in Human Cancer
… I noted that one of these cytokines hCXCL-8 (IL-8) belonged to the ELR+ CXC family of cytokines, suggesting that the entire family of ELR+ CXC cytokines may promote Ras driven tumorigenesis. Indeed, I found that expression of oncogenic Ras led to secretion of all ELR+ CXC chemokines in …
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On the role of mast cells in chemokine-induced leukocyte recruitment
… are divided into two major subfamilies, CC and CXC. In general, CC chemokines exert chemotactic influence on monocytes and lymphocytes while CXC chemokine mainly attract neutrophils. However, the mechanisms of chemokine-induced leukocyte recruitment in vivo remain elusive. Mast cells are tissue …
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Mechanisms of neutrophil recruitment in septic lung injury
… of neutrophils, myeloperoxidase activity, and CXC chemokine in lung measured after CLP. We observed that sepsis triggered clear-cut lung damage characterized by edema formation, neutrophil infiltration, and increased levels of MIP-2 in the lung. We demonstrate that immunoneutralization with …
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Characterization of the Role of Glutaredoxin 3 and Its Binding Partners In Maintaining Iron Homeostasis In Saccharomyces Cerevisiae
… with a zinc-finger DNA binding domain and a CxC putative iron binding region was purified and tested for Fe-S cluster binding. When subjected to Fe-S cluster reconstitution, our preliminary evidence suggests that Aft2(1-204) binds a [2Fe-2S] cluster and forms a homodimer. Mutation of either …
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HOW ENGLISH LANGUAGE HEAD OF DEPARTMENTS PERCEIVE THEIR ROLES in TEACHER DEVELOPMENT AND TEACHER EFFICACY: A STUDY of EIGHT JAMAICAN SCHOOLS
… of the concerns about Jamaica’s poor ratings in CXC English Language passes and my perception that insights into how H.O.D.s perceived their roles could possibly generate a solution to enable them to facilitate teaching learning experiences that could redound to improved CXC English Language …
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SIGNALING MECHANISMS IN SEPSIS-INDUCED IMMUNE DYSFUNCTION
… recruitment of neutrophils via reduction of CXC chemokine production in lung macrophages and neutrophil activation in the circulation. It was noted that Rho-kinase inhibitor reduced sepsis-induced pulmonary recruitment of neutrophils and tissue injury via regulation of CXC chemokines …
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BIOLOGICAL AND TRANSDUCTIONAL EFFECTS OF ALLOSTERIC ANTAGONISTS ON THE ACTIVITY OF CHEMOATTRACTANT RECEPTORS
… expressed on the surface of neutrophils, CXCR1 and CXCR2.It is thought that targeting both receptors may be necessary for optimal inhibition of PMN influx in several inflammation disorders such as post-ischemia reperfusion injury, pulmonary fibrosis, sepsis, psoriasis among other. DF 2156A …
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Cxcr2 Expression In Tumor Cells Is A Poor Prognostic Factor and Promotes Invasion and Metastasis In Lung Adenocarcinoma
<p>CXC chemokine receptor 2 (CXCR2) is a G-protein coupled receptor which mediates signaling by binding to CXC chemokines CXCL1-3 and 5-8. In non-small cell lung cancer CXCR2 has been studied mainly in stromal cells and is known to increase tumor inflammation and angiogenesis. However, there is …
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The Role of Gene Transcription and Inflammatory Cytokines in Bone Fracture Repair
… third aim of this dissertation, we examined the CXC family of chemokines in skeletal repair through deletion of CXC family receptor 2 (Cxcr2). Several members of the CXC chemokine family are among the most highly upregulated genes following skeletal injury. Despite this, their impact of fracture …
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Effects of CXCL8 Overexpression on Tumor Cell Proliferation and Migration in an HNSCC Cell Model
… the chemotactic cytokines known as chemokines. CXCL8 (Interleukin-8), a CXC ELR+ Chemokine mainly responsible for neutrophil chemoattraction, has beenimplicated in increased tumor proliferation, migration and angiogenesis. The current studytests the effects of CXCL8 on the tumor proliferation …
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On Semi-isogenous Mixed Surfaces
… Let us consider a finite group acting on CxC, having some elements that exchange the factors, and assume that the subgroup of those elements that do not exchange the factors acts freely. We call the quotient a Semi-isogenous Mixed Surface. In this work we investigate these surfaces and we …
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Genome sequencing and phenotypic analysis of single cells in cancer
… heterogeneity in secretions of ELR+ CXC chemokines from single tumor and stromal cells and demonstrate how the true behavior of single cells can be hidden in bulk assays. We also describe assays to measure the growth kinetics of tens of thousands of single cells in parallel and to …
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Cxcr2 Macromolecular Complex In Pancreatic Cancer: A Potential Therapeutic Target In Tumor Growth
… signaling mediated by the chemokine receptor CXC chemokine receptor 2 (CXCR2) plays an important role in promoting the progression of many cancers, including pancreatic cancer, one of the most lethal human malignancies. CXCR2 possesses a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl …
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On Leukocyte Recruitment in Cholestatic Liver Injury
… of rhokinase attenuates cholestasis-induced CXC chemokine formation, leukocyte recruitment and hepatocellular damage in the liver. Thus, the results of this thesis clearly demonstrate that leukocyte recruitment in the liver plays a key role in the pathophysiology of cholestasis. Accordingly, …
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Adhesive and signaling mechanisms in abdominal sepsis
… secretion from platelets and via decreasing CXC chemokine formation in the lung. Moreover, HMG-CoA reductase inhibition maintained CD4 T-cell function in spleen by reducing apoptosis and by improving proliferation as well as by preserving the ability to produce IFN-γ in the spleen. Moreover, …
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