Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"CX3CR1"”.
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CX3CR1 Neuroimmune Microglial Cell Forkhead Box Class O1 (FoxO1) Contributions to Metabolic Homeostasis
… (FoxO1) in the (CX3C Chemokine Receptor 1) CX3CR1-microglial cell population leads to suppression &/or resistance to high-fat diet (HFD) diet induced obesity (DIO) metabolic consequences in a sexually-dimorphic manner in an CX3CR1 FoxO1-KO in vivo model.
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Sequential Changes of CX3CR1 in Dorsal Root Ganglion in a Rat Model of Lumbar Disc Herniation
… 요추간판 탈출증 모델 연구에서 케모카인중 하나인 프랙탈카인과 프랙탈카인의 수용체인 CX3CR1에 대한 연구는 대부분 척수 후각에서 연구되었으며 후근신경절에서의 CX3CR1의 시간적 변화에 대한 연구는 아직까지 보고된 바 없다. 이에 본 연구에서는 자가 수핵을 이용한 요추간판 탈출증 모델을 이용하여 통증의 발현 변화와 함께 후근신경절에서의 시간적 변화에 따른 CX3CR1의 발현 양상을 알아보고자 하였다. 백서에서 자가 수핵을 이용한 신경병증성 통증 모델을 만든 후 술 후 1일, 5일, 10일, 20일, 30일에 통각과민과 …
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An Examination of the Roles of CX3CR1 and Microglia in a Mouse Model of Degenerative Cervical Myelopathy
… as a major mediator of microglial activation, CX3CR1 represents a key target to understand and potentially treat secondary injury after decompression. We demonstrate that CX3CR1-signaling and Cx3cr1+ microglia impact immune responses after surgical decompression in a mouse model of DCM by …
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Characterizing the roles of gut microbiota, probiotic Lactobacilli and CX3CR1 in the development of autoimmunity in MRL/lpr mice
… combination. Additionally, our group generated a Cx3cr1-deficient MRL/lpr mouse which exhibits a distinct phenotype of exacerbated glomerulonephritis with concurrent change of the gut microbiota composition compared to Cx3cr1+/+ MRL/lpr littermates. Interestingly, upon correction of the gut …
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The Cx3Cl1-Cx3Cr1 Chemokine Axis Contributes to Tumor Immune Evasion and Its Blockade Enhances Responses to Anti-Pd-1 Immunotherapy
… playing a critical role in metastasis of CX3CR1 expressing cancer cells. While CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration, the mechanisms employed by this axis on these cells to mediate immune suppression remain poorly …
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Rheumatoid arthritis and atherosclerosis: common pathogenic mechanisms explored
… compared. I describe how a polymorphism of the CX3CR1 gene, which has been shown to have a protective association against atherosclerosis, is shown to have has a similar protective association against RA. Using immunohistochemistry and confocal microscopy, I demonstrate that monocytes …
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An Investigation of the Interplay Among CX3CR1, Immune Cells, and Gut Microbiota in Lupus-Associated Arthritis and Renal Disease using the MRL/lpr Mouse
… were studied to better understand the disease. CX3CR1, a surface protein that guides cell migration, was found to influence the production of inflammatory proteins IL-17A and IL-17F, as well as the gut microbiota—bacteria living in the gut. The gut microbiota was observed to influence IL-17A but …
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Structural mechanisms of experience-dependent synaptic plasticity in the mouse visual cortex
… functioning via the fractalkine receptor (CX3CR1) in OD plasticity following 3 days of MD. I first identify increased lysosomal content in microglia within layer 4 (L4) of binocular visual cortex following MD, which suggests microglia participate in this structural rearrangement. As it is …
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Investigating the role of macrophage-epithelial cell interaction in salivary gland regeneration
… currently remains unknown. Here, I show that CX3CR1+ macrophages home specifically to ductal cells following radiation injury, and that DNA damage is more severe upon the genetic depletion of macrophages compared to radiation alone. In addition, via in vivo analysis and a novel method for ex …
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Phenotype and function of intestinal CD103+ dendritic cells
… subset, expressing the chemokine receptor CX3CR1+ has been suggested to take up intestinal luminal antigens via transepithelial dendrites. The focus of this thesis has been to phenotypically and functionally characterize intestinal CD103+ DCs and to investigate the mechanisms that underlie …
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Visualizing The Dynamics of Immune Surveillance In Brain Tumors By Intravital Multiphoton Microscopy
… the BT core, CD11c+ DCs at the tumor margin, and CX3CR1+ microglia outside the tumor. T cells formed clusters around CD11c+ DCs, but not the microglia. Within these clusters, T cells vigorously interacted directly with CD11c+ DCs. CD11c+ DCs retained T cells and controlled their motility patterns, …
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Mechanisms of microglia induced retinal degeneration
… by neurons. The chemokine CX3C motif receptor 1 (CX3CR1) is expressed exclusively by microglia in the central nerves system (CNS) and the retina; whereas the ligand, chemokine C-X3-C motif ligand 1 (CX3CL1) is expressed by neurons. The interaction between CX3CL1 and CX3CR1 is an important …
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The Role of Fractalkine-mediated Neuroprotection in the Diabetic Retina
… DR. The microglia-neuronal crosstalk mediated by CX3CR1 and fractalkine (CX3CL1; FKN) signaling provides a neuroprotective environment in several neurological diseases. FKN is a protein expressed on neuronal membranes (mFKN) and undergoes constitutive cleavage to release a soluble domain (sFKN), …
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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
… stimulation. Knockout (KO) of the FKN receptor CX3CR1, which is specifically expressed on microglia, protected synapses from gp120-induced degeneration. These results indicate that the neuron-to-microglia intercellular FKN/CX3CR1 signaling is critical for gp120-induced synaptic degeneration. To …
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Effects of a Simulated Tennis Match on Lymphocyte Subset Measurements
… tested, which were CD4, CD8, CD19, CD95, and CX3CR1. Whole blood was added to red blood cell lysis buffer and fixation buffer, and the blood solution was incubated with antibodies specific to cell phenotype. The main results of this study indicated that there was a decrease in mainly post cell …
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Identifying the role of microglia in mediating ASD-relevant phenotypes in the adult brain
… of microglia-deficient rodent models such as Cx3cr1-/- mice display ASD-relevant behaviours such as hyperactivity and excessive grooming. As Cx3cr1 is also expressed by neurones and astrocytes it is unclear whether the ASD phenotypes seen in these mice are microglia specific. Csf1r deficient …
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The ontogeny and function of intestinal dendritic cells
… studies had identified a major subset of CX3CR1+ mononuclear phagocytes which, by virtue of their capacity to sample antigen from the intestinal lumen, were thought to play key roles in the initiation of intestinal adaptive immune responses. In paper I, we assess the relationship between …
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Steroid induced neuroprotection of damaged photoreceptor cells
… photoreceptor-microglial, fractalkine-CX3CR1 signalling 1000-fold in the P20 rd10 mouse. Known to prevent microglial activation, we hypothesise that Norgestrel acts as a vital anti-inflammatory in the diseased retina, driving fractalkine-CX3CR1 signalling to delay retinal degeneration. …
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Phylogenetic Analysis of Human Cytomegalovirus pUS27 and pUS28: Ascertaining an Independent or Linked Evolutionary History
… ancestor, the gene for human chemokine receptor CX3CR1, suggesting that a single human gene was captured and that a viral gene duplication event occurred. It also appears that after the gene duplication event, US27 may have undergone neofunctionalization, while US28 maintained the function of …
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