Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"CX3CL1"”.
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Crosstalk between CX3CL1 and the Cytoskeleton during Vascular Inflammation
… cells and the unique transmembrane chemokine, CX3CL1, which is strongly implicated in the recruitment of leukocytes to the vascular intima and the progression of atherosclerosis. I document a novel cytoskeletal regulatory mechanism that limits the interactions between CX3CL1 and the …
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The Cx3Cl1-Cx3Cr1 Chemokine Axis Contributes to Tumor Immune Evasion and Its Blockade Enhances Responses to Anti-Pd-1 Immunotherapy
<p>CX3CL1 secreted in the tumor microenvironment serves as a chemoattractant playing a critical role in metastasis of CX3CR1 expressing cancer cells. While CX3CR1 can be expressed in both cancer and immune-inhibitory myeloid cells to facilitate their migration, the mechanisms employed by this axis …
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Investigating the role of macrophage-epithelial cell interaction in salivary gland regeneration
… and tissue-resident macrophages occur via the CX3CL1-CX3CR1 axis. Using CX3CL1 reporter mice I confirm that KRT14+ cells produce CX3CL1, the sole ligand for CX3CR1, providing robust evidence that macrophages directly communicate with KRT14+ cells during the repair process. Indeed, upon the …
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Identification of Anti-Beta2 Glycoprotein I Auto-antibody Regulated Gene Targets in the Primary Antiphospholipid Syndrome Using Gene Microarray Analysis
… were induced including chemokines CCL20, CXCL3, CX3CL1, CXCL5, CXCL2 and CXCL1, the receptors Tenascin C, OLR1, IL-18 receptor 1 and growth factors, CSF2, CSF3, IL-6, IL1 and FGF18. Downregulated genes were transcription factors/signaling molecules including ID2. Microarray results were …
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The role of stromal cells in the establishment of Glioblastoma tumour microenvironment immunosuppression
… ICAM-1 and VCAM-1, and chemokines such as CX3CL1, compared to their NNP counterparts. In contrast, GBM stromal cells also showed an increase in the expression of the cytokine, IL-6. To investigate the changes in signalling pathways resulting in these differing responses, key inflammatory …
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Sequential Changes of CX3CR1 in Dorsal Root Ganglion in a Rat Model of Lumbar Disc Herniation
… 염증 매개체가 관여하는 것으로 되어 있다. 이중에서 케모카인 중의 하나인 프랙탈카인(CX3CL1)은 말초신경 손상의 경우 신경세포에서 유리되어 척수 후각의 미세아교세포를 활성화함으로써 통증을 촉진하는 것으로 보고하고 있다. 수핵을 이용한 요추간판 탈출증 모델 연구에서 케모카인중 하나인 프랙탈카인과 프랙탈카인의 수용체인 CX3CR1에 대한 연구는 대부분 척수 후각에서 연구되었으며 후근신경절에서의 CX3CR1의 시간적 변화에 대한 연구는 아직까지 보고된 바 없다. 이에 본 연구에서는 자가 수핵을 이용한 요추간판 탈출증 모델을 …
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Mechanisms of microglia induced retinal degeneration
… the ligand, chemokine C-X3-C motif ligand 1 (CX3CL1) is expressed by neurons. The interaction between CX3CL1 and CX3CR1 is an important mechanism to avoid uncontrolled microglial activation. Microglia can be activated by inflammatory cytokines through the JAK/STAT pathway of cytokine …
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Small Solutions to Big Problems: Design and Synthesis of Nanoparticles for Biomedical Applications
… streptavidin-Cy3, interferon gamma (IFN-γ), and CX3CL1. Poly(methacrylic acid), chitosan, and polyinosinic-polycytidylic acid (poly(I:C)) were successfully adsorbed to the surfaces of nanoparticles to enhance particle stability and targeting. Iron-based coupling media capable of eliminating ~ 90% …
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The Role of Fractalkine-mediated Neuroprotection in the Diabetic Retina
… crosstalk mediated by CX3CR1 and fractalkine (CX3CL1; FKN) signaling provides a neuroprotective environment in several neurological diseases. FKN is a protein expressed on neuronal membranes (mFKN) and undergoes constitutive cleavage to release a soluble domain (sFKN), while the C-terminal …
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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
… gp120. Fractalkine (FKN; a.k.a.CX3C ligand-1 or CX3CL1), a microglia-activation chemokine that is specifically expressed in neurons, was up-regulated in response to gp120 stimulation. Knockout (KO) of the FKN receptor CX3CR1, which is specifically expressed on microglia, protected synapses from …
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Identifying sm22 as a key player in arterial diseases
… molecules including Vcam1, Icam1, Cx3cl1, Ptgs2 and Ccl2. The medial chondrogenesis was characterized by augmented expression of type II collagen, aggrecan, osteopontin, Bmp2 and the key osteochondrogenic transcription factors Sox9. In accordance with the in vivo findings, …
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The effect of testosterone on factors associated with diabetes, atherosclerosis and obesity.
… Testosterone decreased secretion of CCL2 and CX3CL1 from 3T3L1 adipocytes while increasing PAI-1 mRNA expression in these cells. The action of testosterone was based on the type of cells and time, route and dose size of treatment. In conclusion, although testosterone therapy showed a positive …
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Visualizing The Dynamics of Immune Surveillance In Brain Tumors By Intravital Multiphoton Microscopy
… of the neuronal chemokine Fractalkine (CX3CL1). Deficiency of the Fractalkine receptor CX3CR1 resulted in decreased CD11c+ DC recruitment. In addition, decreased CD11c+ DC recruitment was accompanied by decreased T cell recruitment, an increase in the spatial diffusion of the few …
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Influenza infection induces neuroinflammation and impacts hippocampal structure and function
… (BDNF, NGF), and immunomodulatory (CD200, CX3CL1) factors. To better understand the cellular mechanisms underlying these effects, changes in microglia reactivity and hippocampal neuron morphology were assessed at the same timepoint in which heightened inflammation and cognitive deficits …