Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CX-5461"”.
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Characterizing and targeting the genomic consequences of ATRX deficiency in glioma
… of action and efficacy of the G4 stabilizer CX-5461 as both a single agent and in combination with ionizing radiation (IR), a mainstay in the current standard of care, using patient-derived glioma stem cell (GSC) preclinical models. We found that ATRX-deficient GSCs demonstrate dose-sensitive …
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rRNA transcription as potential therapeutic target in triple negative breast cancers
… different levels of genotoxicity. Three drugs, (CX-5461, BMH-21 and PMR-116) are small molecules and selective inhibitors of RNAP1 transcription which have moderate effect on transcription by other nucleolar polymerases and protein translation and which are at different stages of clinical …
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Exploring genetic interactions with G-quadruplex structures
… three G4-stabilising ligands (PDS, PhenDC3 and CX-5461) using an independent siRNA approach. The latter siRNA methodology was used to screen 12 PDS derivatives with improved medicinal chemistry properties and ultimately identified SA-100-128, as a lead compound. The mechanism behind synthetic …
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Functional genetics reveals surprises about the mechanisms of action of chemotherapeutics
… the recently developed anti-cancer compound, CX-5461, was discovered to inhibit Topoisomerase 2 as its primary mechanism of action, instead of the previously assumed RNA polymerase I inhibition. Finally, new functional genetic tools were developed for examining tumor progression and …
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Functionalising peptide hydrogels to improve drug delivery for the treatment of glioblastoma
… hydrogels. We show that three anticancer agents (CX-5461, PMR-116 and fucoidan) can be incorporated into the hydrogels without disrupting the hydrogel assembly mechanism or the anticancer activity of the drugs in GBM cells. In addition, we show that the method of drug incorporation has a major …
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Functionalising peptide hydrogels to improve drug delivery for the treatment of glioblastoma
… hydrogels. We show that three anticancer agents (CX-5461, PMR-116 and fucoidan) can be incorporated into the hydrogels without disrupting the hydrogel assembly mechanism or the anticancer activity of the drugs in GBM cells. In addition, we show that the method of drug incorporation has a major …