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Showing 1 to 1 of 1 for “"CUL4B-DDB1 complex"”.
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Role of 4E-BP2 in neuronal translation
… because it binds with higher affinity to a complex, comprising the mTORC1 protein Raptor and the ubiquitin E3 ligase CUL4B. Deamidated 4E-BP2 (2D) stability is regulated by mTORC1 and AMPAR activity but not NMDARs. We also showed that 4E-BP2 deamidation is neuron-specific and occurs in human …