Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CUGBP1"”.
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Global analysis of mRNA decay rates and RNA-binding specificity reveals novel roles for CUGBP1 and PARN deadenylase in muscle cells
… and function of the RNA-binding proteins CUGBP1 and MBNL1 are disrupted, resulting in altered mRNA metabolism at the levels of splicing and translation. Intriguingly, despite strong evidence for CUGBP1 being a regulator of mRNA turnover in humans and other organisms, the possibility that …
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Understanding regulation of mRNA by RNA binding proteins
… splicing factors RBFOX2, MBNL1 and CELF1/CUGBP1. For each factor, the canonical motifs are recovered as well as additional near-optimal binding motifs. RNA secondary structure inhibits binding of RBFOX2 and CELF1, while MBNL1 favors unpaired Us but tolerates C/G pairing in UGC-containing …
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Regulation and function of the RNA-binding protein CELF1
… of mRNA decay is the RNA binding protein CUGBP1 and Etr3 Like Factor 1 (CELF1). CELF1 binds to a GU-rich element (GRE) harbored in target transcripts and promotes their rapid decay through the recruitment of RNA decay enzymes. The work presented in this thesis focused on elucidating the …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… binding proteins (RBPs), calreticulin (CRT) and CUGBP1, which were previously described to compete for binding to <em>CDKN1A</em> full-length mRNA and have opposite effects on p21 translation. Importantly, these two RBPs also compete for binding to <em>SPUD</em>. Furthermore, I showed that …