Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 54 for “"CTX"”.
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Multiple levels of regulation are associated with the production of CTX-M-14 and CTX-M-15 beta-lactamases in Escherichia coli
… Enterobacteriaceae is increasing rapidly. CTX-M type β-lactamases are the most prominent ESBL family worldwide and are produced mainly by E. coli. blaCTX-M-14 and blaCTX-M-15 genes are the dominant alleles circulating worldwide. The massive spread of CTX-M-producing organisms in both …
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The emergence of <i>Escherichia coli</i> with CTX-M extended-spectrum beta-lactamases in the United Kingdom
… multi-resistant <i>Escherichia coli</i> with CTX-M enzymes have rapidly become the leading producers of extended-spectrum β-Iactamases (ESBLs) worldwide. <i>E. coli</i> with CTX-M-15 β-Iactamases are the most common, and are now endemic in many UK hospitals and in the community. Their …
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Reevaluating Chlorotoxin Targets: Insights Into Glioblastoma Cell Migration and Neuropilin-1 Binding
… GBM is one such strategy. Chlorotoxin (Ctx), a 36-amino-acid residue polypeptide derived from Leiurus quinquestriatus scorpion venom, has shown selective binding to GBM cells, making it a promising candidate for diagnostic applications and improving tumor visualization. However, the …
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Diversidad de Beta-lactamasas de espectro extendido y de líneas genéticas en aislados de Escherichia coli de diferentes ecosistemas en La Rioja
… clínicas de E. coli resistentes a cefotaxima (CTXR) obtenidas durante 2004-2007 en el Hospital San Pedro de Logroño y 72 de ellas fueron productoras de BLEEs (73 %). La mayor parte de las cepas clínicas de E. coli BLEE+ correspondían a aislados de la comunidad (67 %) y fundamentalmente de …
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Investigation of biofilm development by antibiotic resistant urinary tract infection pathogens and evaluation of antimicrobial activity of Manuka honey on Escherichia coli CTX-M-15 biofilms
… and gene expression in Escherichia coli CTX-M-15 were investigated in this study. The antivirulence efficacy of Manuka honey as an alternative treatment was analysed for this strain. Method Biofilm formation was measured using the Tissue Culture plate method at different times: after 6, …
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The development of targeting nanosystems for the treatment of glioblastoma and neuroblastoma tumours
Chlorotoxin (CTX) peptide selectively targets glioblastoma multiforme (GB) and neuroblastoma (NB) and has excellent blood-brain barrier permeability. Therefore, CTX is a promising targeting molecule for nanoparticle (NP) based diagnostic and therapeutic applications. Bimetallic gold-platinum …
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Post-Translational Modifications of the Paired Box Transcription Factor 7 (Pax7) in Satellite Cells During the Repair of Injured Skeletal Muscle
… wild-type mice were injected with cardiotoxin (CTX) to induce muscle injury. The TA muscles where harvested 4, 7, 14, or 21 days post-injection to analyze the satellite cell response to regulate muscle repair following the CTX injury. Western Blot data showed that the total protein abundance of …
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The Effects of Dietary N-3 Polyunsaturated Fat from Plant Versus Marine Sources on Bochemical Markers of Bone Turnover in Healthy Adults
… markers of bone turnover [c-telopeptide (CTX); procollagen Type I N-terminal propeptide (PINT); and osteocalcin (OC)] were analyzed in serum at the end of each diet period in both studies.</p> <p><strong>Results:</strong>There were no significant changes in serum CTX, P1NP, and OC among …
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Epidemiological Typing and Mechanisms of Antibiotic Resistance in Clinically Relevant Klebsiella Pneumoniae Isolated at St. Marina University Hospital – Varna // Епидемиологично типизиране и механизми на антибиотична резистентност в клинично значими Klebsiella pneumoniae, изолирани в УМБАЛ „Света Марина“, Варна
… самостоятелно продуцирани така и в комбинация с CTX-M. При четири изолата се установи продукция на два вида CTX-M ензими. 4. Основният механизъм на резистентност към цефалоспорини от трета генерация в настоящата колекция от изолати K. pneumoniae се асоциира с продукцията на ESBLs в 96.9%, като …
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Beyond MICS: Determining the Role of Porin Production and β-Lactamase Expression in Resistance and Cellular Physiology of Klebsiella pneumoniae
… in transport of the outer membrane porins. CTX-M-15 expression was associated with differential expression of genes in the Rcs, Cpx, and σE regulon. Removal of the CTX-M-15 signal sequence altered the transcriptomic profile and led to upregulation of cytoplasmic chaperones but did not fully …
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Molecular detection, quantification and characterization of extended-spectrum β-lactamase (ESBL)- and AmpC-encoding genes in a cucumber agroecosystem
… (83.09%), blaTEM (69.01%), blaOXA (36.62%), blaCTX-M-Group-1 (35.21%) and blaCTX-M-Group-9 (9.86%)] and pAmpC, encoding genes [blaCIT (2.82%), blaEBC (2.82%), blaACC (1.41%), blaMOX (1.41%) and blaDHA (1.41%)] in the Enterobacteriaceae isolates. Thereafter, using Sanger sequencing, the gene …
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The Volcanic Evolution of Syrtis Major Planum, Mars
… data as the base layer, and draws on 6 m/pixel CTX data to provide additional information. Map 2 is a 1:250,000 scale map of the Nili Patera caldera and uses base layer mosaics of CTX data and CTX Digital Terrain Models. The mapping shows that there were two major phases of magmatism at Syrtis …
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Characterization of β-lactamases and Porins in Uropathogenic E. coli
… of the plasmid-borne β-lactamases, CMY-2, CTX-M-14, CTX-M-15, and KPC and the protein production of the porins, OmpC and OmpF in E. coli clinical isolates were characterized. It was hypothesized that increased β-lactamase production and/or outer membrane porin aberrations would result in …
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Biomarker Response After an Acute Running Bout in Participants with and without an Acute Knee Injury History
… concentrations (i.e., COMP, IL-1ß, MMP-13, CTX-II, CPII, and CTX-II/CPII ratio) assessed in this study were not found to be significantly different based on AKIH status pre exercise and after 30 min of running. AKIH participants did have significantly lower pre-exercise functional scores …
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Transcriptional Heterogeneity in ALS: Patients with Retrovirus-mediated Disease and Potential Cell-type Specific Therapeutic Approaches
… and controls were identified in the cortex (CTX) and spinal cord (SC). Differential expression analysis (DEA) revealed that certain loci associated with human endogenous retrovirus K (HERV-K), a type of transposable element (TE), as well as other non-TE features were dysregulated in patient …
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Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis
… to co-deliver IKBKE siRNA and cabazitaxel (CTX) for TNBC therapy. IKBKE siRNA significantly inhibits the proliferation, migration, and invasion of TNBC cells but has no apoptosis-inducing effect. In vivo studies also indicated that IKBKE siRNA can inhibit TNBC tumor growth. CD44-targeting …
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Community perspectives on vitamin D and bone health in three at-risk populations.
… significantly with c-terminal telopeptide (CTx) (P = 0.03), but not with age, body mass index, levels of fasting glucose or PTH. BMI and PTH levels were significantly correlated with each other (P = 0.001). c) CTx was suppressed after 12 months for all osteopenic participants (p=0.04) with …
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Mecanismos de resistencia y virulencia de aislados clínicos de klebsiella spp. Productores de beta-lactamasas de clase a, c y d: caracterización de los cambios producidos durante la colonización/infección
… spp., se describió por primera vez la variante CTX-M-273 (CTX-M-15 P167S), cuyo impacto en la resistencia a ceftazidima/avibactam se validó mediante ensayos de clonación. Finalmente, el estudio de la dinámica de plásmidos en este último grupo de aislados sugirió la transferencia horizontal intra …
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Global characterization of oncogenic kinase signaling
… Firstly, a novel broad-spectrum kinase inhibitor CTx-0294885 was developed and characterized as a kinase-capturing tool in order to increase the kinome coverage of the profiling technique. Using CTx-0294885 as a single reagent and in combination with others led to the identification of 235 and 261 …
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A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model
… high-frequency electroporation (H-FIRE) and QUAD-CTX tumor receptor-targeted cytotoxic conjugate therapies, individually and in combination, in selectively and thoroughly treating glioblastoma multiforme. In order to achieve this, an appropriate model must be developed and characterized. I have …
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