Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CTSB"”.
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Involvement of the lysosomal cysteine peptidase cathepsin B in tumour progression and formation of metastases
… of the lysosomal cysteine peptidase cathepsin B (CTSB) in tumour progression and metastasis, transgenic mice FVB/N-TgN(MMTVPyVT)634Mul, developing multifocal metastasising mammary carcinomas, were utilised. CTSB deficient mice, with a mixed C57BL/6J and 129SvJ background were made congenic for the …
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Independent predictors of executive function: Cathepsin B and strength
… examine the molecule of interest, Cathepsin B (CTSB), maximal strength testing to assess isokinetic strength using a Biodex dynamometer (Biodex System 3, Shirley, NY), and a Spatial Reconstruction Task to assess relational memory. Attentional inhibition, a component of executive function, was …
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Identification of Cathepsin B and L as Novel Uva Targets Upstream of Cutaneous Lysosomal-Autophagic Dysregulation
… only dual genetic antagonism (targeting both CTSB and CTSL expression) could mimic UVA-induced autophagic-lysosomal alterations, whereas single knockdown (targeting CTSB or CTSL only) did not reproduce the UVA-induced phenotype. Similarly, TEM revealed massive accumulation of …
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Synthesis And Biological Evaluation Of Nitrile-Based Inhibitors Of Cysteine Proteases Caged With Ruthenium Complexes
… for synthesizing nitrile-based caged CTSK and CTSB inhibitors. Light activated release of inhibitors, followed by toxicity and stability data were studied. Cathepsin enzyme activity inhibition in 2D and 3D assays were established. This work showcased the applicability of ruthenium complexes in …