Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"CTPR"”.
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Engineering mono- and multi-valent inhibitors on a modular repeat-protein scaffold to target oncogenic Tankyrase
… and here the consensus-designed TPR (CTPR) sequence was used as a scaffold to create novel arrays of binding molecules. The platform allows us to display single and multiple functions with diverse geometrical arrangements by grafting short binding sequences onto the loops between …
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Engineering Synthetic Biomolecular Condensates with Rationally-Designed Modular Repeat Proteins
… based on consensus tetratricopeptide repeat (CTPR) proteins, modular folded non-globular domains, fused with low-complexity domains (LCDs), intrinsically disordered domains that drive phase separation. By systematically engineering a library of LCD-CTPR constructs sharing identical LCD …
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Bioenabled Synthesis of Anisotropic Gold and Silver Nanoparticles
… Then consensus sequence tetratricopetide repeat (CTPR) proteins with increasing number of repeats were used as model proteins to probe the effects of concentration as well as the protein shape on the morphology and resulting physicochemical properties of plasmonic gold nanoparticles. Since the …
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Designed bifunctional proteins for induced degradation of androgen receptor in prostate cancer
… tetratricopeptide repeat proteins (CTPRs) were deployed as artificial modular scaffolds, onto which AR- and E3 ligase-binding moieties were grafted to induce AR ubiquitination and degradation. As the degraders bind AR through protein-protein interactions, we can effectively target …
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Inhibiting Protein-Protein Interactions using Rationally-designed Repeat Proteins
… tetratricopeptide repeat proteins (CTPRs) make them very amenable to be rationally-designed into potential new PPI inhibitors. This study sets out to investigate whether this could be achieved through the grafting of binding peptides into the inter-repeat loops. The work focused on …
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Probing the protein homeostasis mechanisms in long-lived naked mole-rats
… tetratricopeptide repeat protein (CTPR). The results provide proof-of-concept validation of using CTPR-based probes to detect proteins in emerging animal models. Having established a set of reliable methods to investigate the molecular details of the UPR and autophagy in the NMR, we …
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Biomolecular Condensates Through a Computational Microscope Design, Mechanisms and Implications
… the interaction landscape. Similarly, in CTPR-based constructs and chromatin arrays, valency also emerges as a key determinant of stability, linking molecular-scale interactions to macroscopic properties. This study highlights the critical role of structural and mechanical properties in …