Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CTLH"”.
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Regulation of C-RAF stability by the RanBPM/CTLH complex
… RanBPM is identified as a key member of the CTLH complex, an orthologous complex to a yeast E3 ubiquitin ligase complex, the exact function of which remains unknown. Previously, our laboratory identified RanBPM as an inhibitor of the ERK1/2 pathway through the modulation of C-RAF protein …
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Systematic C-degron activity profiling implicates conditional regulation of the CTLH E3 ligase complex in ribosome maturation.
… by the Muskelin substrate adapter of the CTLH E3 ligase complex. Characterisation of ZMYND19 stability revealed conditional regulation, whereby CTLH-mediated degradation was suppressed by TNF-a stimulation and enhanced by inhibition of mTOR signalling. These findings established that CTLH …
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Characterizing the Role of the E3 Ubiquitin Ligase Subunit MAEA in DNA Repair and Replication
… describes for the first time the role of the CTLH E3 ubiquitin ligase complex catalytic subunit MAEA in the DNA damage response. I identified MAEA through focused CRISPR- Cas9 screens using the chemotherapeutic agents camptothecin and etoposide. My subsequent investigations demonstrate that …
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Precise Temporal Regulation of Ribonucleoprotein Complexes during the Drosophila Maternal-to-Zygotic Transition
… distinct times: the C-terminal to Lis1 Homology (CTLH) complex targets Cup, TRAL and ME31B for degradation early in the MZT; the Skp/Cullin/F-box-containing (SCF) complex targets SMG at the end of the MZT. Deleting the C-terminal 233 amino acids of SMG abrogates interactions with F-box proteins …