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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 163 for “"CTL"”.

  1. Zytotoxische-T-Lymphozyten (CTL)-vermittelte Zytolyse bei der HIV-Infektion

    Ehret, RobertUniversität Würzburg

    … HIV-spezifische zytotoxische T-Lymphozyten (CTL) bewirkt wird, untersucht. Grundsätzlich erscheinen in der Abwehr viraler Infekte sowohl CD4+ wie CD8+ CTL. In chronisch HIV-Infizierten sind in der Regel lediglich CD8+ CTL zu finden. HIV-spezifische CD4+ CTL können aber zum Beispiel in …

    wurz-thes Repository record

  2. How TCR signal strength controls CTL polarisation for target killing

    Frazer, Gordon LeeUniversity of Cambridge2018

    Cytotoxic T lymphocytes (CTL) are major effector cells in the adaptive immune response against intracellular pathogens and cancers, killing targets with high precision. Precision is achieved through the specificity of the clonally expressed T cell receptor (TCR). TCRs recognise a specific peptide …

    cambridge Repository record

  3. THE CRITICAL ROLE OF CD4+ TH CELLS IN CD8+ CTL RESPONSES AND ANTI-TUMOR IMMUNITY

    Sokke Umeshappa, ChannakeshavaUniversity of Saskatchewan2013

    … provide help for CD8+ cytotoxic T lymphocyte (CTL) responses in different immunization types. The establishment of diseases, such as chronic infections and cancers, is attributed to severe loss of or dysfunctions of CD4+ T cells. Even in acute infections, CD4+ T cell deficiency leads to poor …

    sask Repository record

  4. The role of early cytotoxic lymphocyte (CTL) escape in the pathogenesis of HIV-1 subtype C infection

    Ntale, Roman SabaDivision of Virology2012

    … frequency and timing of cytotoxic T-lympthocyte (CTL) escape and its pathogenic consequences on HIV-1 subtype C disease progression.

    cape-town Repository record

  5. Naturally occuring peptides recognized by cytotoxic T lymphocytes (CTS) : peptide abundance as a determinant of CTL function

    Tsomides, Theodore JMassachusetts Institute of Technology1996

    Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.

    mit Repository record

  6. The identification of cytotoxic T lymphocyte (CTL) escape in a large, longitudinal subtype C HIV-1 sequence dataset

    Mphahlele, RuthComputational Biology Division2023

    … rapidly escapes cytotoxic T-cell lymphocyte (CTL) immune responses exerted by the host. Mutation patterns and HLA associated footprints linked to viral escape have been identified, making it possible to use viral sequence data, combined with the host HLA allele information, to predict escape. …

    cape-town Repository record

  7. Impact of Cytotoxic T Lymphocyte (CTL) escape mutations in acute/Early HIV-1 Subtype C Infection on Disease Progression

    Chopera, Denis RutendoDivision of Virology2009

    … strong anti-HIV cytotoxic T lymphocyte (CTL) responses. Evolved evasion mutations that undermine host immune responses pose a major challenge to the development of such vaccines. Understanding the mechanisms that selectively favour the emergence of CTL evasion mutations in vivo and the …

    cape-town Repository record

  8. Characterization of an IL-12-driven Anticancer Response, and the CD4+ CTL Population Incited, in a Murine Model of Leukaemia

    Nelles, Megan Elizabeth2012

    For the treatment of cancer, immunotherapy has some inherent advantages over other treatment modalities: disseminated disease can be eradicated due to the systemic nature of immunity, the immune system is effective against a wide range of targets, long-term memory can offer added protection against …

    toronto-retro Repository record

  9. Identifying regulators of cytotoxic T cell function through molecular and genetic screening

    Strege, KatharinaUniversity of Cambridge2019

    Cytotoxic T lymphocytes (CTL) are crucial components of the adaptive immune system that kill infected and tumourigenic cells. CTL killing requires focused secretion of cytotoxic compounds from lytic granules. This process is known as degranulation. In this study, I aimed to establish the …

    cambridge Repository record

  10. T lymphocyte responses to equid herpesviruses 1 and 4 in horses

    O'Neill, TerryThe Open University1995

    … proliferative and cytotoxic T lymphocyte (CTL) responses in the blood of horses. Equine T cell blast cells stimulated from peripheral blood mononuclear cells (PBMC) with pokeweed mitogen were found to perform best as targets for CTL in "Cr release assays. CTL induced in vitro with an …

    the-open-u Repository record

  11. Untersuchung zur Funktion von Cathepsin B in der durch zytotoxische T-Zellen vermittelten Lyse von Tumorzellen

    Ensslen, Miriam2012

    … darauf, dass zytotoxische T-Lymphozyten (CTL) sich selbst vor der Lyse durch ihr eigenes Perforin mittels Expression von Cathepsin B auf der Zelloberfläche schützen. Interessanterweise wird Cathepsin B auch in vielen Tumorzellen vermehrt exprimiert und ist möglicherweise in die …

    goettingen Repository record

  12. The role of JAK1 and JAK3 in CD8<sup>+</sup> effector T cells

    Rollings, ChristinaUniversity of Dundee2016

    … IL-2 control of effector CD8+ cytotoxic T cells (CTL). On the basis of these preliminary data, a detailed analysis of the effect of tofacitinib on effector CD8<sup>+</sup> T lymphocytes was performed. <br/><br/>Phosphorylation events regulated by tofacitinib were identified using mass spectrometry …

    dundee Repository record

  13. Dissecting the interplay between cytotoxic T lymphocytes and the pancreatic cancer stroma

    Golo, Matteo ; https://orcid.org/0000-0002-1604-3887UNSW, Sydney2026

    Cytotoxic T lymphocytes (CTLs) are key effectors in antitumour immunity, patrolling tissues to detect and destroy cancerous cells by directing cytotoxic granules toward the immunological synapse formed with their target. Although CTL infiltration into solid tumours often correlates with improved …

    unsw Repository record

  14. Respuesta del olivo (cv Arbequina) a riego deficitario bajo condiciones superintensivas en La Rioja

    Arbizu Milagro, JuliaUniversidad de La Rioja (España)2015

    … cinco tratamientos de riego: i) Control (CTL), regado al 100% de la ETc, ii) Riego deficitario controlado con estrés moderado (RDCEM), regado como CTL excepto en la fase II del crecimiento del fruto donde se regó al 50% del CTL; iii) Riego deficitario controlado con estrés severo (RDCES), …

    dialnet Repository record

  15. Low-Frequency Sonophoresis Assisted Cancer Immunotherapy

    Sinha, DiviyaMassachusetts Institute of Technology2021

    … and maintaining a long-lived potent cellular CTL (Cytotoxic T Lymphocyte) response is of significant interest to the global scientific community. Protection against most intracellular pathogens (e.g., HIV) and tumors require functional CTL immunity and are ineffectively treated by antibodies …

    mit Repository record

  16. T cell receptor- and calcium-induced Gli signalling in CD8+ T cell effector function

    Beke, FlavioUniversity of Cambridge2025

    CD8+ cytotoxic T lymphocytes (CTLs) are potent effector cells of the immune system, capable of directly lysing neoplastic and infected cells. The Hedgehog (Hh) signalling pathway - a critical regulator of embryonic development and adult tissue maintenance - is induced in CTLs following TCR …

    cambridge Repository record

  17. Visualizing the dynamics of HIV-specific cytotoxic T-cells in extracellular matrix

    Foley, Maria HotteletMassachusetts Institute of Technology2012

    Cytotoxic lymphocytes (CTLs) traffic through tissues in search of antigen and mount protective immune responses against viral infections and cancer. While molecular mechanisms of CTL antiviral effector functions have been established in vitro, they have been defined in the absence of physiological …

    mit Repository record

  18. Effects of Peripartal Supplementation of Yeast-Based Products on Performance, Rumen Fermentation Profile, and Circadian Rhythms in Dairy Cows

    Begalli, GustavoVirginia Tech2025

    … 100 g/d of ground corn and 25 g/d of placebo (CTL; n = 30) or a basal diet plus 100 g/d of ground corn and 25 g/d of PB (PB; n = 31). Cows were fed 1X/d with TMR, and treatments were top-dressed. From -35 to -22 DIM, cows were fed a far-off diet; from -21d until calving, cows received a …

    vt Repository record

  19. Screening for genes involved in CD8⁺ T cell cytotoxicity and characterisation of a super-killer

    Barton, PhilippaUniversity of Cambridge2020

    Cytotoxic T Lymphocytes (CTL) are cells of the adaptive immune system that are responsible for the elimination of virally infected, tumorigenic or damaged cells through mechanisms that induce target cell lysis. The aim of this project was to identify genes that can impact CTL lytic capacity, using …

    cambridge Repository record

  20. Alternate pathways of cytotoxic T lymphocyte and natural killer cell activation

    Goté, Lisa R.Virginia Tech1995

    … CD44 expressed on cytotoxic T lymphocytes (CTls), can trigger the lytic activity of CTls and redirect CTl-mediated lysis to antigen-negative Fc receptor-positive target cells. Similar redirected lysis was also inducible using mAb MEL - 14, directed against the lymphocyte homing receptor for …

    vt Repository record

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