Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"CTGF"”.
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Connective Tissue Growth Factor in Pancreatitis
… role for connective tissue growth factor (CTGF/CCN2) in pancreatic inflammation and fibrosis in a new model of experimental pancreatitis. Progress in studying alcohol pancreatitis has been hampered by the lack of a cost-effective, reproducible and efficient model in mice, reflecting their …
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Effects of Growth Hormone and Insulin-Like Growth Factor-I on Milk Protein Gene Expression and Nutrient Uptake and Cell Proliferation in Clonal Bovine Mammary Epithelial Cells
… the role of connective tissue growth factor (CTGF) on IGF-I-stimulated proliferation of MAC-T cells was investigated. A microarray analysis revealed that IGF-I decreased CTGF mRNA expression in MAC-T cells (P < 0.01). This effect of IGF-I was further found to be mediated through the PI-3 …
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Development of drug screening assays for identification of new molecules against pancreatic ductal adenocarcinoma
… partner in the functional activity of YAP and CTGF is considered one of the main representative target genes whose expression is regulated by this couple of transcriptional regulators.Chromatin immunoprecipitation experiments allowed us to demonstrate that GF 109203X interferes with YAP binding …
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The Transformation of Human Retinal Pigment Epithelial Cells
… TGFβ induces myofibroblast markers (αSMA and CTGF), although vitreous suppresses their expressions. Vitreous also down-regulates the expression of TGFβ. The combination of TBI replicates the effect of vitreous as it decreases αSMA and CTGF. IL1β suppresses myofibroblast markers. In a dose- …
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A Stem Cell-Based Strategy for Modeling Human Kidney Disease and Discovering Novel Therapeutics
… revealed that the mechanosensitive proteins YAP, CTGF, and Cyr61 may be viable endogenous therapeutic targets, while CTGF and Cyr61 expression could serve as biomarkers of podocyte mechanical integrity and cell health. Additionally, our preliminary high-throughput drug screens have identified …
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Biomechanical regulation of arteriogenesis : defining critical endothelial-dependent events
… of Connective tissue growth factor (CTGF). Moreover, delivery of endothelial conditioned medium generated throughout the collateral flow experiments to culture smooth muscle cells (SMC) resulted in the modulation of SMC genes related to vessel maturation and stabilization. In the …
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Phenotypic Characterization of Segmental Human Trabecular Meshwork Cells
… Relative expressions of COLIV, TIMP1, SPARC, CTGF, and MMP1 mRNA in segmental cells seeded on soft and stiff hydrogels, and on glass (control) were assessed; (2b) and phagocytic ability with/without DEX for 72 h, was quantified. Results: (1) LF VehM was 2-fold stiffer than HF VehM (p < 0.05). …
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Investigating the role of PKC-β in tumour activated stromal cells
… in part by connective tissue growth factor (CTGF). BMSC- derived CTGF promotes CLL survival and drug resistance. My data show that PKC-β inhibitors antagonise activation of BMSCs to a cancer associated fibroblast (CAF)-like phenotype. In-vivo expression of PKC-β was confirmed in fibroblasts …
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CONNECTIVE TISSUE GROWTH FACTOR IS REQUIRED FOR CHONDROGENESIS
Connective tissue growth factor (CTGF, CCN2) is expressed by mesenchymal cells during development. Mice genetically deficient in CCN2 display severe bone defects and die immediately after birth. The molecular basis of this defect is not known. We've used in vitro models of chondrogenesis to show …
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Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
… Moleküle der extrazellulären Matrix wie Ctgf, Timp3, TenascinC und die Integrine α 3 und α 5, sowie Moleküle die eine regulierende Funktion auf TGF-β Signale selbst ausüben können wie Smad7, Igf2r und Fstl3. Durch die Regulation von Genen, die an der Übertragung von Notch- und …
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Der Einfluss von Mycophenolat-Mofetil (MMF) auf die renale Fibrogenese: Bedeutung für neue therapeutische Ansätze
… werden. Die Effekte von MPA auf eine veränderte CTGF-Expression waren z.T. IMPDH-abhängig, z.T. IMPDH-unabhängig. Des Weiteren zeigten die beschriebenen Effekte eine Abhängigkeit vom zeitlichen Verlauf. So führte MPA initial zu einer supprimierten Genexpression von CTGF, später jedoch zur …
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Cullin 4B Ubiquitin Ligase Is Important for Cell Survival and Regulates TGF-β1 Expression in Pleural Mesothelioma
… of Hippo pathway genes including YAP1, CTGF, and survivin. Interestingly, CUL4B and not CUL4A knockdown reduced TGF-β1 and MMP2 expression, suggesting a unique association of CUL4B with this pathway. However, the treatment of PM cells with exogenous TGF-β1 following CUL4B knockdown did …
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… decrease in connective tissue growth factor (CTGF), a 43.1% inhibition in phosphorylated Smad 2 and a 66.2% reduction in phosphorylated ERK1/2 in the arteriole wall of the cremaster muscle. Microvascular remodeling was independent of TGF-beta expression. The dual-specificity phosphatase-1 …
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Regulation of endometrial repair and its impact on heavy menstrual bleeding
… (AM), connective tissue growth factor (CTGF) and endothelin-1 (ET-1) were all maximally expressed during the menstrual and/or proliferative phases of the cycle, consistent with the onset of endometrial repair. Endometrial cells and tissue explants treated with 100nM PGE2/F2α and/or …
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Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
… Expression of the YAP/TAZ downstream genes like CTGF, CYR61 and ANKRD1 were elevated in the SIRT6-deficient HSCs. Biochemical and mutagenic analyses have revealed that SIRT6 deacetylates YAP and TAZ at key lysine residues and reprograms the composition of the TEA domain transcription factor …
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Modelling Human Glomerulosclerosis in vitro
… of fibrosis in the 3D tri‐culture, TGF‐β and CTGF were demonstrated as key inducers of fibrosis. With a synergistic relationship, both cytokines required targeting for successful attenuation of fibrosis. Direct targeting of TGF‐β is impractical due to its varied and systemic modes of action. …
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Sgk1 como mediador de los efectos deletéreos del receptor de mineralocorticoides
… Finally, we validated two additional genes, CTGF and PTGD, as direct MR targets that are directly or indirectly involved in the development of cardiovascular disease.
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Analyse der Differenzierung von Makrophagen aus embryonalen Stammzellen im Mausmodel
… differentiation processes were identified, e.g. Ctgf encoding the connective-tissue growth factor and Csf1, the macrophage-colony stimulating factor. This data demonstrates that embryonic stem cell derived macrophages show typical properties of macrophages but at the same time can be …
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The Role of the Discoidin Domain Receptor-1 (DDR1) in Vascular Smooth Muscle Cell (VSMC) Mechanosensing
… of Ddr1 and the canonical YAP/TAZ target gene Ctgf. In summary, these studies show a key role for DDR1 as a stiffness sensor in vascular smooth muscle cells to influence vascular pathologies like vascular calcification. DDR1 can mediate mechanosignaling via a positive feedback loop between DDR1 …
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