Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 135 for “"CTD"”.
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Mechanisms of recruitment of the CTD phosphatase Rtr1 to RNA polymerase II
The C-terminal domain (CTD) of the RNA polymerase II (RNAPII) subunit Rpb1 must exist in a hypophosphorylated state prior to forming a competent transcription initiation complex. However, during transcription, specific kinases and phosphatases act on the RNAPII CTD to regulate its phosphorylation …
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Time-dependent assimilation of CTD data to an open ocean Rossby wave model
For two CTD surveys taken two months apart during the 1981 Ocean Tomography experiment southwest of Bermuda, a time-dependent ocean state is estimated that evolves from the first to the second survey. The mesoscale motions are modelled by quasi-geostrophic dynamics, and the ocean model state is …
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The functions of the RNA polymerase II CTD in transcription and RNA processing
… activity, possesses a unique c-terminal domain (CTD) that consists of tandem heptad repeats with the consensus sequence of Tyr-Ser-Pro-Thr-Ser-Pro-Ser (Y1S2P3T4S5P6S7). Somewhat reflecting the complexity of the organism, the number of repeats varies, from 26 in yeast to 52 in vertebrates. The …
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Time-dependent assimilation of CTD data to an open ocean Rossby wave model
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Earth, Atmospheric, and Planetary Sciences, 1993.
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Interstitial lung disease (ILD) in adult patients with autoimmune connective tissue disease (CTD) at Groote Schuur Hospital
… other autoimmune connective tissue diseases (OCTD) which included idiopathic inflammatory myopathies, mixed connective tissue disease, systemic lupus erythematosus, primary Sjogren's syndrome and overlap syndromes. Factors associated with usual interstitial pneumonia (UIP) subtype were …
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DNA topology and Pol II CTD phosphorylation as stepwise regulators of chromatin architecture in differentiating human stem cells
… phosphorylation of its C-terminal domain (CTD), which modulates interactions with co-transcriptional regulators and condensates. These mechanisms likely intersect: phosphorylated Pol II may be recruited to negatively supercoiled or secondary structure-forming sites, while negative …
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Evaluating the impact of "Consent and capacity: everyday decision-making in long-term care" on staff critical thinking disposition.
… development of critical thinking disposition (CTD). This pilot study used a pre-test-post-test mixed methodology design to evaluate the impact of C&C ED in LTC on staff CTD. The California Critical Thinking Disposition Inventory (CCTDI) was used to measure CTD pre and post-C&C ED in LTC. The …
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Using constant time delay to teach the recognition of functional sight words to students with significant intellectual disabilities
… to measure the effects of a Constant Time Delay (CTD) intervention. CTD was implemented as an intervention to support four transition students’ abilities to recognize functional sight words. The sessions were held during a summer transition program on a large university campus where students were …
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Structural principles governing kinase specificity towards RNA polymerase II C-terminal domain and their impact on transcription
… of tools – the most interesting being the CTD of Pol II. The CTD sequence consists of seven amino acids repeated multiple times (Up to twenty-six repeats in yeast and fifty-two repeats in humans). Phosphorylation is just one of the many post-translational modifications carried out on the …
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Investigating the effect of simulated diabetic claw toe deformity on the gait patterns of healthy adults
… foot abnormalities, such as claw toe deformity (CTD). Areas of high pressure have been shown to correlate with common ulcer sites including MTPJs and hallux; however, little research has been carried out to identify the links between foot deformity, gait changes and ulcer development. Research …
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Characterization of the Association of mRNA Export Factor Yra1 with the C-terminal Domain of RNA Polymerase II in vivo and in vitro
<p>The unique C-terminal domain (CTD) of RNA polymerase II (RNAPII), composed of tandem heptad repeats of the consensus sequence YSPTSPS, is subject to differential phosphorylation throughout the transcription cycle. Several RNA processing factors have been shown to bind the appropriately …
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Architecture of Escherichia coli promoters that respond to reactive nitrogen species
… substitutions in the carboxyl terminal domain (CTD) of the α subunit of RNA polymerase was used to demonstrate direct interaction between NarL and RNA polymerase. NarL, the CTD of NarL, NarXL, NarP and the CTD of NarP were expressed from plasmids and transcription activation studied in cells …
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Investigation of the Polyprimidine Tract-Binding Protein-Associated Splicing Factor (PSF) Domains Required for the Hepatitis Delta Virus (HDV) Replication
… to interact with the carboxy terminal domain (CTD) of RNA polymerase II (RNAPII), and to facilitate the interaction of RNA transcripts with the CTD of RNAPII. Both PSF and RNAPII were found to interact with both polarities of the terminal stem loop domains of HDV RNA, which possess RNA promoter …
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Biomolecular condensation of intrinsically disordered regions in P. falciparum and H. sapiens transcription factors
… the P. falciparum RPB1 C-terminal domain (PfRPB1-CTD) that suggest a functionally divergent role in biomolecular condensation. This work demonstrates that the PfRPB1-CTD, as well as a panel of GTF-IDR fusion proteins, including P. falciparum (Pf) and Homo sapiens (Hs) TATA-binding protein-IDR …
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Improvements to the Cheng-Todreas wire-wrapped rod bundle friction factor correlation in response to pin number and in the transition flow region
The Cheng-Todreas Detailed (CTD) Pressure Drop Correlation (1986) is the most accurate correlation for measuring the pressure drop of sodium coolant through a Sodium-Cooled Fast Reactor (SFR). Although CTD is the most accurate correlation, there is room for improvement with new data and modern ways …
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Investigating the Biological Mechanisms Underlying Axis Morphogenesis Using a Novel Zebrafish Model of Idiopathic-like Scoliosis
… mutants present with a curly tail down (CTD) phenotype and are embryonic lethal. Using functional genetic approaches, I demonstrated that a dominant mutation in the gene scospondin (sspo) causes both the dmh4 scoliosis and CTD phenotypes. I showed that both CTD and scoliotic zebrafish …
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Influences of first-line oral monotherapy on outcomes in Pulmonary Arterial Hypertension in association with Connective Tissue Disease.
… association with connective tissue disease (PAH-CTD) is the most rapidly progressive and difficult to treat. Management of PAH has evolved significantly in the past ten years since the introduction of oral therapies. Evidence for the efficacy of these agents outside randomised controlled trials …
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Structural insights into RNA binding by NusA and interaction studies of Nun with E. coli Nus factors.
… free state, NusA cannot bind to RNA. Once alpha-CTD of RNA polymerase is bound to NusA the RNA binding inhibition is released. Direct interactions between alpha-CTD and NusA ar2 have been reported and therefore NusA ar2 could be a prime candidate for inhibiting the RNA binding of NusA. To further …
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Advancing Pattern Detection, Theory Development and Decision Making with Explainable AI
… computationally intensive theory development (CTD) is a subject of ongoing debate, particularly concerning how and whether these methods can be effectively employed, and how the reliability of their explanations can be ensured. This dissertation addresses these issues by systematically …
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