Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"CTCs"”.
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Μελέτη της προβλεπτικής αξίας κυτταρικών υποπληθυσμών στο μυελό των οστών και στο περιφερικό αίμα ασθενών με πολλαπλό μυέλωμα
… για τα κυκλοφορούντα καρκινικά κύτταρα (CTCs) στο πολλαπλό μυέλωμα (MM), αλλά η χαμηλή τους συχνότητα στο περιφερικό αίμα (PB) καθώς και τα διάφορα όρια (cut-offs) που έχουν προταθεί από διαφορετικές επιστημονικές ομάδες θέτουν ερωτήματα ως προς την κλινική τους χρησιμότητα. Σκοπός της …
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Optimisation of the isolation and identification of circulating melanoma cells
… disease progression. Circulating tumour cells (CTCs) are released into the bloodstream by the tumours within a patient, this being a key step in melanoma spread. Since CTCs can be detected in the blood of metastatic melanoma patients, these cells can be used as a “liquid biopsy”, providing …
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Biological and Clinical Significance of Circulating Tumor Cells in Breast Cancer
Circulating tumor cells (CTCs) represent a unique source of information that might help clarifying numerous aspects of metastasis biology and finding new clinically relevant biomarkers. On the hypothesis that CTCs possess a distinct profile compared to solid primary and secondary lesions, the …
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LINEAGE TRACING REVEALS PAEP AS A CHEMOTHERAPY-INDUCED METASTATIC DRIVER AND EXPOSES METABOLIC VULNERABILITIES OF CIRCULATING TUMOR CELLS IN BREAST CANCER
… metastasis‐derived circulating tumor cells (CTCs), with the goal of revealing actionable vulnerabilities. I adapted a human TNBC (MDA‐MB‐231) xenograft to a clinically relevant AC regimen that produced stable disease, mirroring chemoresistant residual disease in patients. High‐complexity …
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Social factors associated with adherence/non adherence to Antiretroviral therapy among People Living with HIV/AIDS. The case study of three CTCs, Mwananyamala, Amana and Temeke in Dar es Salaam
… in selected three care treatment centers (CTCs) that were Mwananyamala, Amana and Temeke. The interview questions designed in form of open ended questions. The purposes of using such tools were to give the respondents a wide room of expressing their feelings, ideas and opinions about the …
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Cell and nanomaterial-based approaches for diagnosis and chemotherapy of metastatic cancer cells
… secondary tumor, and circulating tumor cells (CTCs). While much work has focused on primary tumors, less effort has concentrated on targeted isolation, detection and therapy of deeply penetrated metastases and CTCs. Here, I discuss cell and nanomaterial-based approaches for detecting and …
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Functional characterization of mobilized tumor cells
… mobilized tumor cells: circulating tumor cells (CTCs), intraoperatively shed tumor cells, and malignant pleural effusions (MPE). We investigated the functional behavior of mobilized tumor cells in order to explain the discrepancy between the number of tumor cells in circulation and the number …
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Development and evaluation of methodologies for analysis of CTC and ctDNA in patients with ovarian carcinoma
… improve phenotypic characterization of detected CTCs, genomic validation of putative CTCs, and the evaluation of the clinical validity of ctDNA as biomarker of response to neoadjuvant chemotherapy (NACT). This thesis consists of six chapters: a general introduction to OC (Chapter 1); a thorough …
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A blood exchange method to study circulation kinetics of tumor cells in the blood
… estimated vastly conflicting half-life time of CTCs, ranging from seconds to hours. However, these studies are limited in that they typically involve monitoring the decay in concentration of injected in vitro cultured cells, rather than that of native, unprocessed tumor cells. Measuring the …
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Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma
… Aims: We proposed that circulating tumour cells (CTCs) are a viable source of tumour genetic material in which patient prognosis could be analysed. Firstly, we aimed to increase the sensitivity of an immunomagnetic enrichment protocol to capture CTCs. Secondly, we aimed to evaluate whole genome …
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Experimental Validation of Heteroclinic Orbit Dynamics in Inertial Microfluidics
… label-free isolation of circulating tumor cells (CTCs) for liquid biopsy applications. CTCs are extremely rare in blood, making their separation both technically challenging and clinically significant. Inertial microfluidics offers a promising alternative to traditional methods by exploiting …
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An optofluidic platform for longitudinal circulating tumor cell studies in mouse models of cancer
… cancer-related deaths. Circulating tumor cells (CTCs) that are shed from primary tumors represent the disseminating "seeds" that give rise to distant malignant growths. Despite their importance to metastasis, understanding of their role has been hindered by the extreme difficulty of …
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Microfluidic-based Fluorescence Detection for Biomarker Analysis
… The first platform described here is to isolate CTCs with high purity by using 2-stage sorting technique and herringbone features for aliquot stretching, including axial and lateral mixing to spread cells. We achieved a roughly 70-fold improvement in target cell purity to 70%, compared to our …
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Development of High-speed Photoacoustic Imaging technology and Its Applications in Biomedical Research
… and imaging of circulating tumor cells (CTCs) in melanoma models, which can provide valuable information about a tumor’s metastasis potentials. We probed the melanoma CTCs at the near-infrared wavelength of 1064 nm, where the melanosomes absorb more strongly than hemoglobin. Our …
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INFERRING TUMOR PROPERTIES FROM GENE EXPRESSION DATA
… detection by means of circulating tumor cells (CTCs) or cell-free RNA (cfRNA) and the identification of mislabelled cell lines. So far those problems have been addressed separately but we ask if one classifier is sufficient to solve them all and investigate what are the determinants of cancer …
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Technologies for the isolation of circulating tumor cells
… cancer-related deaths. Circulating tumor cells (CTCs) are exceedingly rare cells found in the whole blood of cancer patients which have the potential to serve as a 'blood biopsy'. The intricate characterization of these cells could result in an entire new class of therapies directly targeting …
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The hybrid epithelial/mesenchymal phenotype and its implications in cancer metastasis
… as clusters of Circulating Tumor Cells (CTCs) that can be apoptosis-resistant and can initiate 50 times more tumors as compared to individually migrating CTCs. However, the hybrid E/M remains poorly characterized and has been tacitly assumed to be ‘metastable’ or transient. This study, …
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Genome sequencing and phenotypic analysis of single cells in cancer
… genome from single circulating tumor cells (CTCs) is both possible and useful clinically. We also describe a statistical framework for evaluating amplification bias in single-cell sequencing and two new methods for enriching CTCs from blood. In the second half of my thesis, I present our …
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Selective Isolation of Circulating Tumor Cells in Antibody-Functionalized Microsystems
… number of BT-20 cells at a concentration of 500 CTCs per milliliter blood or 50 CTCs per milliliter blood. After a pretreatment to enrich the CTCs, the samples were driven through microchannel arrays functionalized with anti-EpCAM. For both samples, around 55% of the target CTCs were captured in …
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Bioengineered surfaces and hydrogels for specific cell capture and release from whole blood
… and releasing rare circulating tumor cells (CTCs) from the whole blood of a prostate cancer patient; specific immunostaining indicated that the released cells were CTCs based on their expression of cytokeratin and prostate specific antigen. This technology has the promise to significantly …
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