Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"CTC1"”.
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Clarifying the Role of the CST Complex in DNA Replication and Repair
… including the shelterin complex and CST (CTC1 – STN1 – TEN1) complex. CST is an RPA-like ssDNA binding protein that is vital for telomere length maintenance via inhibition of telomerase and stimulation of DNA polymerase α -primase during C-strand fill-in synthesis. CST is also known to …
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Mechanisms That Ensure the Proper Terminal Structure of Mammalian Telomeres
… while promoting the telomeric function of the Ctc1/Stn1/Ten1 (CST) complex. Though the role of CST is not well understood, Ctc1 and Stn1 were originally identified as accessory factors of DNA polymerase α/primase and may contribute to fill-in synthesis of the telomeric C-rich strand. Finally, …
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On the Second Telomere Maintenance Machine: Structure, Recruitment, and Regulation of the CST–Polα/primase C-strand Fill-in Complex
… and DNA Polymerase α (Polα)/primase bound to Ctc1/Stn1/Ten1 (CST). Decades of research have focused on telomerase, which extends the G-rich telomeric strand to counteract telomere shortening in germline and stem cells. More recently, CST–Polα/primase,which synthesizes the complementary C-rich …
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Biochemical and structural studies of human telomerase regulation
… repeats, telomerase is terminated by a CST (CTC1-STN1-TEN1) complex (Feng et al., 2018). In my thesis, I describe the biochemical and structural work aimed at understanding the molecular basis of human telomerase and its interaction with regulatory factors. In Chapter 2, I reconstruct …