Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"CT26"”.
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Comparative Study of Colon Cancer Subclones Uncovers Potential Roles for AKAP7 and TP53RK in the Antiviral Response.
… the murine OV-resistant colon cancer cell line CT26.WT and its hypersensitive subclone CT26.lacZ. This study led to the identification of retroviral insertion sites in AKAP7 and TP53RK genes, that are potentially involved in conveying sensitivity to infection by OVs and the dysregulation of the …
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Orthotopic liver metastasis mouse models of mismatch repair-proficient colorectal cancer recapitulate clinical inefficacy of immune checkpoint blockade
… CRC do not respond to ICB therapy. MC38 and CT26 are two of the most commonly used mouse syngeneic CRC cell lines in preclinical studies of colorectal cancer. In most of these preclinical studies, MC38 and CT26 are implanted under the skin in the hind flank of the mice where they grow into …
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Applications of Ephb4 Receptor Specific Peptides In Targeted Cancer Imaging and Therapy
… RAW specifically bind to CT26 and PC-3M cells but not to A549 cells. In vivo, Small-animal PET/CT clearly showed the significant uptake of <sup>64</sup>Cu-DOTA-TNYL-RAW in CT26 and PC-3M tumors but not in A549 tumors. Furthermore, µPET/CT and near-infrared optical imaging …
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Studies on immunology of Leishmania mexicana
… Antigen (SLA), L. mexicana gp63 cDNA and CT26 tumour cells transfected with L. mexicana gp63, were compared. It was shown that DNA immunisation using L. mexicana gp63 generated the highest immunity to the parasite among the four tested vaccines where the killed leishmania vaccine and L. …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
… mRNAs in a mouse metastatic tumor model using CT26.CL25 cells. CT26.CL25 cells are VEGF-producing murine colon carcinoma cells transfected with the lacZ gene, which expresses B-galactosidase activity. These cells, injected intravenously, form tumor nodules in the lung. A pilot study revealed …
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Development and Characterization of B7-H3-Targeted Radioimmunotherapies For The Treatment of Solid Tumors
… harboring established syngeneic subcutaneous CT26 tumors, a radio-resistant colorectal cell type transfected with human B7-H3 (CT26 hB7-H3) compared to with tumors transfected with vector control (CT26 vector). Mice whose tumors regressed in response to <sup>90</sup>Y-DOTA-MIL33B treatment …
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
… a Th1-type profile. Finally, the combination of CT26-derived TEXs and MBP-D8-mFAT1 OMVs elicited synergistic protective activity against mouse challenge with CT26 cell line. Conclusions OMVs decorated with tumor antigens elicit antigen-specific, protective anti- tumor responses in mice. The …
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… was not, however, found to be effective in the CT26 colorectal carcinoma and the DEN-induced Hepatocellular carcinoma. Combination therapy with CFA and anti-CTLA-4, which blocks the inhibitory effects of CTLA-4 on T cells, did not improve CFA treatment efficacy in either the P815 or 4T1 models, …
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The Treatment of Solid Tumours with Complete Freund's Adjuvant
… was not, however, found to be effective in the CT26 colorectal carcinoma and the DEN-induced Hepatocellular carcinoma. Combination therapy with CFA and anti-CTLA-4, which blocks the inhibitory effects of CTLA-4 on T cells, did not improve CFA treatment efficacy in either the P815 or 4T1 models, …
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Toll-Like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice
… GI tissue by Entolimod. In a syngeneic mouse CT26 colon adenocarcinoma model, Entolimod reduced the systemic toxicity of 5-FU, but did not reduce its antitumor efficacy indicating that the protective effect of Entolimod was selective for normal, noncancerous tissues. These results suggest that …
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Immunostimulatory activity and antitumor efficacy of mSOT201 immunocytokine
… completely cured all MC38 and the majority of CT26...
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Identification and Knockout of Immunodominant Endogenous Retroviral Antigen in Murine Tumor Models
… for preclinical studies B16F10, MC38, 4T1, and CT26 were able to produce replication-competent eMLV able to infect other murine cells in vitro and T cells in vivo. Human tumors have not been shown to produce infectious ERV, and so we removed the infectious potential of these murine tumor models …
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Potentiation of The Immune Checkpoint Blockade Response By Metabolic Modulation Is Predictable Using Molecular Imaging
… (ITPP), increases oxygen release into the TME of CT26 and 4T1 tumors, increasing tumor immunogenicity and potentiating ICB tumor control. Tumor control using ITPP and ICB can be predicted using Multispectral Optoacoustic Tomography (MSOT) to measure oxygen saturation (SO2). This effect corresponds …
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Modulation of Pi3K-Akt Pathway In Colorectal Cancer
… of combined PI3K and PD-1 inhibition in CT26 CRC mouse model.</p> <p>We conclude that AKT inhibition in metastatic CRC induces FOXO-mediated adaptive upregulation of RTKs, namely IGF1R, possibly reactivating the pathway. PI3K-altered MSS CRC is an immunologically distinct subgroup with …
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Development of new photoluminescent sensing materials, systems and applications for cell analysis
… extracellular pH in grafted tumours produced by CT26 cells and freshly excised from animals on a portable FLIM imager. The new pH sensors and dual pH/O2 sensors showed high stability (>1 year of storage), fast response and stable calibration, being well-suited for detailed metabolic studies of …
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Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
… and extends survival of Colon Tumor #26 (CT26) tumor-bearing mice. Our study demonstrated the feasibility of using phage display to discover new innate immune checkpoint inhibitors. Our results also suggested that the anti-CD47 peptides represent a promising innate immune checkpoint …
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Discovery of IKBKE and CD24 siRNAs for the treatment of triple-negative breast cancer
… tumor growth and increased the survival of CT26 tumor-bearing mice. The CLV3 dAb is therefore a promising PD-L1 inhibitor that can be used for cancer immunotherapy.
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New photonic imaging systems for biomedical applications
… the grafts. The live animals were injected with CT26 cells stained with the NanO2-IR probe to develop tumours with characteristic phosphorescence. The animals were monitored, and tumours were allowed to grow for 3, 7, 10 and 17 days. O2 imaging of live and euthanized animals at different time …