Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"CST complex"”.
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Clarifying the Role of the CST Complex in DNA Replication and Repair
… are protected by a number of essential protein complexes including the shelterin complex and CST (CTC1 – STN1 – TEN1) complex. CST is an RPA-like ssDNA binding protein that is vital for telomere length maintenance via inhibition of telomerase and stimulation of DNA polymerase α -primase during …
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Mechanisms That Ensure the Proper Terminal Structure of Mammalian Telomeres
… the telomeric function of the Ctc1/Stn1/Ten1 (CST) complex. Though the role of CST is not well understood, Ctc1 and Stn1 were originally identified as accessory factors of DNA polymerase α/primase and may contribute to fill-in synthesis of the telomeric C-rich strand. Finally, to identify …
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Biochemical and structural studies of human telomerase regulation
… telomeric repeats, telomerase is terminated by a CST (CTC1-STN1-TEN1) complex (Feng et al., 2018). In my thesis, I describe the biochemical and structural work aimed at understanding the molecular basis of human telomerase and its interaction with regulatory factors. In Chapter 2, I reconstruct …