Global ETD Search
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Showing 1 to 2 of 2 for “"CST–Polα/primase"”.
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On the Second Telomere Maintenance Machine: Structure, Recruitment, and Regulation of the CST–Polα/primase C-strand Fill-in Complex
… to do so: telomerase and DNA Polymerase α (Polα)/primase bound to Ctc1/Stn1/Ten1 (CST). Decades of research have focused on telomerase, which extends the G-rich telomeric strand to counteract telomere shortening in germline and stem cells. More recently, CST–Polα/primase,which synthesizes …
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53BP1/Shieldin Counteract DSB Resection Through Fill-In Synthesis
… of long 3' overhangs at DSBs by recruiting CST/Polα to counteract resection, challenging the long-standing model of a block to resection by this pathway. Like loss of 53BP1/RIF1/shieldin, disruption of CST/Polα/primase reverses the hallmarks of BRCA1- deficiency. CST/Polα localize to DSBs, …