Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"CSPGs"”.
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Altering Inhibitory Extracellular Matrix Promotes Remyelination
… response. Chondroitin sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules that provide structural rigidity to tissues and act as signalling molecules to neurons and glia in the developing nervous system. After injury, CSPGs become highly upregulated by astrocytes as …
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hepatocyte growth factor inhibits glial scar formation and
… species of chondroitin sulfate proteoglycans (CSPGs) that act as a potent inhibitor of axon growth. Thus, inhibition of glial scar formation and/or suppression of CSPGs production may support axonal regeneration following spinal cord injury. Hepatocyte growth factor (HGF), which was originally …
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Identification of the receptor for cellular internalization of an anti-nucleic acid antibody, 3D8 scFv
… (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) that are highly negatively charged molecules known as endocytic receptors for a variety of ligands. Treatment of soluble HS or CS reduced cell surface binding of 3D8 scFv to intact HSPGs. Intracellular co-localizations of three molecules were …
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MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
… injury, chondroitin sulfate proteoglycans (CSPGs) accumulate within the glial scar that forms at the lesion site in response to the insult. CSPGs inhibit axonal growth and regeneration, an action mediated by their sulfated glycosaminoglycan (GAG) chains, especially those with 4-sulfated (4S) …
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Developing an astrocyte-selective AAV-ADAMTS4 gene therapy to promote repair after spinal cord injury
… of chondroitin sulphate proteoglycans (CSPGs) after injury, which are potent inhibitors to axon regeneration and plasticity. A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS4) is a human enzyme that catalyses the proteolysis of CSPG protein cores. Infusion of …
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Restoring bladder function by promoting neuronal regeneration
… in part by chondroitin sulfate proteoglycans (CSPGs) manufactured by reactive astrocytes and oligodendrocytes. We examined the influence of the GDNF family neurotrophin artemin on the neuroarchitecture and extracellular matrix composition of the dorsal spinal cord following a bilateral dorsal …
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Effect of maternal separation on stress-related proteins measured in a 6-hydroxydopamine rat model of Parkinson’s disease
… proteins, chondroitin sulphate proteoglycans (CSPGs) or Nogo-A.
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… of inhibitory chondroitin sulfate proteoglycans (CSPGs) by reactive astrocytes in vitro, and this can be attenuated with noggin or LDN193189 treatments in SCI rats. Despite these early benefits, our work reveals that acute inhibition of BMP antagonism was not sufficient to improve long-term …
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Characterising changes in pathology and function in clinically relevant models of spinal cord injury and using chondroitinase ABC gene therapy to promote repair
… inhibitory chondroitin sulphate proteoglycans (CSPGs). However, ChABC treatment has met with limited success in more traumatic, translational models of SCI, such as contusive or compressive injuries. As such injury models mimic the most common form of SCI in humans, it is important to show …