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Showing 1 to 2 of 2 for “"CSN6"”.
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Cop 9 Signalosome Subunit 6 Stabilizes Cop1, A Novel E3 Ubiquitin Ligase For 14-3-3Σ
… the first time that COP9 signalosome subunit 6 (CSN6) associates with COP1 and is involved in 14-3-3σ ubiquitin-mediated degradation. Mechanistic studies show that CSN6 expression leads to stabilization of COP1 through reducing COP1 self-ubiquitination and decelerating COP1’s turnover rate. We …
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The Novel Upstream Regulator of Fbxw7
… constitutive photomorphogenic 1 (COP1), AKT and CSN6 (i.e. the COP9 signalosome 6).</p> <p>COP1 is an E3 ubiquitin ligase targeting important substrates such as, p53, 14-3-3-σ, and c-Jun. I found that COP1 binds to FBXW7 at the binding motif at V200 and P201. Interestingly, binding between COP1 …