Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"CSN5"”.
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COP9 signalosome subunit knockdown in K562 provides novel insight into the function and potential regulation of the CSN
… In this study the deneddylase catalytic subunit CSN5 and the non-catalytic subunit CSN2 were knocked down in the human haematopoietic cell line and chronic myeloid leukemia model, K562. Both knockdowns had similar consequences for CRL activity whilst having divergent effects on the levels of SRS …
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Role of the COP9 Signalosome In Defense Responses In tomato
… was shown that silencing of the CSN subunit <em>CSN5</em> resulted in reduced wound-and herbivory-induced levels of jasmonic acid and reduced expression of wound-response genes. Unexpectedly, these plants also showed increased pathogenesis-related gene expression. Consequently, …
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Disentangling bacterial virulence mechanisms: Klebsiella pneumoniae targets post-translational modifications (PTMs) to manipulate innate immunity
… via increased expression of the deNEDDylases CSN5 and SENP8. This prevents activation of the E3 ubiquitin ligase component Cullin1 to reduce ubiquitin-mediated PP2Ac degradation. <br/><br/>Reduced ISGylation was achieved by increased expression of the deISGylase USP18 during infection. …
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Post-translational modifications of c-FLIP: opportunities for therapeutic intervention
… E3 ligases which alter FLIP'S stability. CSN5, a component of the COP9 signalosome was identified from a DUB screen for FLIPl, but had also appeared on a yeast-2- hyrbid screen for FLIPl from our laboratory. It was found to interact with FLIP in a ubiquitination-dependent manner and when …
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Functional analysis of novel protein-protein interactions involving ROP GTPases in Arabidopsis thaliana and Populus trichocarpa
… ROP11 also interacts with the COP9 subunit CSN5A in Arabidopsis. We confirmed the interaction of ROP11 and CSN5A in Y2H and employed available mutants for ROP11 and CSN5A in Arabidopsis to genetically characterize this interaction. Surprisingly, loss of ROP11 was found to rescue the csn5a-2 …
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Jab1 Negatively Regulates Pten and Promotes Resistance to Trastuzumab In Her2-Positive Breast Cancer
<p>HER2-positive breast cancer, which is characterized by the over-expression of the HER2 onco-protein, accounts for approximately 20% of all breast cancer cases. Trastuzumab (Herceptin), the first targeted therapy approved for HER2-positive disease, potently prevents the activation of signaling …