Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 7 of 7 for “"CSF-Biomarker"”.
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Modeling the Early Identification and Intervention of Alzheimer’s Disease
Advances in neuroimaging and biomarkers now provide the ability to detect evidence for the pathophysiological process of Alzheimer’s disease (AD) before clinically detectable dementia. Because of these findings, AD research has begun to focus on the preclinical or prodromal stages of the disease. …
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Predictive ability of cerebrospinal fluid biomarkers in diagnosing and evaluating Parkinson's disease
… promising relationships between various biomarkers and Parkinsonian symptoms that could lead to objective measures by using statistical methods and providing p-values. However, we could not find any literature that uses machine learning or directly tests predictive value. The goal of this …
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Sex-Differences in Early-Onset Alzheimer's Disease
… sex and then by APOE ε4 carrier status. Imaging biomarkers were compared across strata, and voxel-wise multiple linear regressions generated statistical maps of gray matter density, amyloid, and tau PET burden. Chapter 3 analyses evaluated the impact of sex and APOE ε4 on plasma and cerebrospinal …
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Identification of Functional Variants in Alzheimer's Disease-Associated Genes
… are also associated with cerebrospinal fluid (CSF) amyloid-beta 1-42 (Aβ<sub>42</sub>) and phosphorylated tau<sub>181</sub> (ptau<sub>181</sub>) levels, we combined CSF biomarker datasets from several studies and performed single-variant, set-based, and conditional analyses for each locus. …
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Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease
… AD have been validated over the years, where CSF biomarkers are one of the most recent and accurate markers. The generally perceived notion today is that these biological markers will be altered also in the preclinical phase. An additional aspect is that a review made in this thesis of the …
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SMN DEFICIENCY INDUCES NEUROACTIVE AMINOACIDS DYSMETABOLISM: BRIDGING INSIGHTS FROM PRECLINICAL MODELS TO CLINICAL EVIDENCE IN SMA PATIENTS
… therapeutic strategies and robust biomarkers to enable personalised disease management. We investigated how SMN deficiency disrupts amino acid metabolism and neurotransmission across central and peripheral systems, integrating data from SMA mouse models, Drosophila, and patient …