Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"CSF-1"”.
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Differentiation and activation of functionally distinct macrophage populations by CSF-1 and GM-CSF
… progenitor cells (BMDM) under the influence of CSF-1 or GM-CSF were compared for immune function. CSF-1- and GM-CSF-derived BMDM did not differ in their ability to kill L929 tumor targets or produce IL-6 and LTC$\sb4$ in response to IFN-$\gamma$ and LPS. CSF-1-derived BMDM secreted more …
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Regulation of proto-oncogenes and immune system genes during CSF-1-induced macrophage differentiation
CSF-1-induced bone marrow-derived macrophage (BMDM) differentiating in vitro acquire both antigen presenting and tumoricidal capabilities. In order to understand the molecular origin of macrophage diversity transcriptional and post-transcriptional regulation of genes involved in affector and …
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Colony Stimulating Factor-1 Receptor (CSF-1R) Expression, Degradation, and Signaling in Lipid-Laden Macrophages
… growth factor colony stimulating factor-1 (CSF-1); however, understanding the changes in CSF-1 signaling and related pathways in foam cells remain poorly investigated. Lipid-laden macrophages were formed through exposure of murine bone marrow derived macrophages to 100 μg/ml acetylated LDL …
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Characterization Of The Skeletal Phenotype In Idua-W392X Knock-In Mice: Bone Metabolism Biomarkers
… quantified: collagen (I), RANKL, OPG, TNFα, and CSF-1 isolated from tibiae of wild type, heterozygous, and DUAW392X mice. No significant differences were found between the genotypes for PINP, TRAP5b, and transcription levels of type I collagen. Lower transcriptional levels were found for RANKL, …
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Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model
… by several of these factors, in particular CSF-1. Given the ability of PI3K signaling to promote osteoclast survival and activity in a CSF-1R dependent manner, we hypothesized that inhibition of CSF-1R or PI3K signaling with compounds GW2580 and ABT-869, and IC87114, respectively, would …
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Periventricular white matter damage in the post-natal brain in hypoxic conditions
… and macrophage-colony stimulating factor (M-CSF) expression was observed. Immunoexpression of these was specifically located in AMC from 24h-7d. However, CSF-1 receptor (CSF-1R), TNF-a and IL-1ß immunoexpression was increased in the astrocytes from 7-14d. TNF receptor 1 (TNF-R1) and IL-1 …
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The role of Nox2 containing NADPH oxidase in hypertensive heart disease
… crucial in the chemotaxis of these cells towards CSF-1 stimulation. Also the speed and persistence of their migration was significantly reduced following the loss of Nox2.<br/>Chimeric mice (WT mice with Nox2-/- marrow and Nox2-/- mice with WT marrow) were generated in-house by lethal radiation …