Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"CSF biomarkers"”.
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Association between CSF Biomarkers and Performance on Neuropsychological Test in Patients with Mild Cognitive Impairment
… tau (P-Tau) in cerebrospinal fluid (CSF). To increase prognostic specificity of MCI to AD, studies have linked findings in CSF to neuropsychological profiles in MCI. The aim of this research was to find out if there is an association between critical biomarkers, such as tau and Aβ42 …
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Tests, Tests, and More Tests: A New Era for Dementia Diagnosis
Cerebrospinal fluid: CSF) proteins correlate with pathological changes that are hallmarks of Alzheimer’s disease: AD). CSF biomarkers have been used in research settings to predict AD diagnosis and rate of cognitive decline, however their use in clinical settings is limited. Given their potential …
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Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease
… affects the course of disease, we analyzed CSF levels of phosphorylated tau (P-tau) and assessed WMLs on brain scans in healthy controls and patients with mild cognitive impairment. We found that a pathological level of P-tau and WMLs in the parietal lobes independently increased the risk of …
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Predictive ability of cerebrospinal fluid biomarkers in diagnosing and evaluating Parkinson's disease
… promising relationships between various biomarkers and Parkinsonian symptoms that could lead to objective measures by using statistical methods and providing p-values. However, we could not find any literature that uses machine learning or directly tests predictive value. The goal of this …
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Neurodegenerative Biomarkers in Healthy Elderly - with special reference to the preclinical pattern of biological and cognitive markers for Alzheimer’s disease
… AD have been validated over the years, where CSF biomarkers are one of the most recent and accurate markers. The generally perceived notion today is that these biological markers will be altered also in the preclinical phase. An additional aspect is that a review made in this thesis of the …
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Long-term treatment response, predictors and biochemical markers in Alzheimer’s disease.
… placement but did not influence survival. CSF T-tau and P-tau were possible markers for disease severity and P-tau for the abundance of symptoms in AD. A fast pre-treatment progression rate was a positive predictor for response to ChEI treatment even after adjusting for disease severity, …
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Identification of Novel Fluid Biomarkers for Alzheimer's Disease
… cognitive impairment draws medical attention. Biomarkers that can detect AD pathology in its early stages and predict dementia onset and progression would, therefore, be invaluable for patient care and efficient clinical trial design. To discover such biomarkers, we measured AD-associated …
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Biomarkers of neurological tissue injury and inflammation in paediatric tuberculous meningitis
… and advanced tools for these are lacking. Biomarkers of neurological injury could help to assess severity and to prognosticate, but have not been assessed in paediatric TBM. This study examined serum and cerebrospinal fluid (CSF) biomarkers of neurological injury in paediatric TBM in …
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Hereditary diffuse leukoencephalopathy with spheroids: Insights into an adult onset neurodegenerative disease
… cases, radiological images, cerebrospinal fluid (CSF) biomarkers and molecular genetic data to place HDLS in a nosographic context and define its relationship with other neurodegenerative disorders. We updated the original Swedish HDLS family and created a pedigree consisting of 166 individuals. …
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Investigating the Differences between Neuropsychological and Physiological Markers in a PTSD-only Group Among Vietnam Veterans
… further assessment of the differences between CSF amyloid, CSF ptau, and PTSD symptoms, specifically sleep, may expand current research on AD risk factors and biomarkers. A total of 179 participants were included in this study and were split into two groups: a PTSD group (n = 96) and a control …
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DNA methylation of the clusterin promoter: Associations with Alzheimer’s Disease risk and related phenotypes
… in CLU (rs9331888/rs11136000), and pathological biomarkers (Chapter 3.2). The second study aimed to analyse the influence of methylation on longitudinal cognitive performance (Chapter 3.3). Aims The overarching aim of the study was to investigate methylation within the CLU promoter region in …