Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 419 for “"CSF"”.
-
Differentiation and activation of functionally distinct macrophage populations by CSF-1 and GM-CSF
… progenitor cells (BMDM) under the influence of CSF-1 or GM-CSF were compared for immune function. CSF-1- and GM-CSF-derived BMDM did not differ in their ability to kill L929 tumor targets or produce IL-6 and LTC$\sb4$ in response to IFN-$\gamma$ and LPS. CSF-1-derived BMDM secreted more …
-
Intranasal delivery of therapeutics targeted to CSF and Brain
… to the brain and cerebrospinal fluid (CSF) respectively. Therapeutic agents targeting CNS are currently being administered by invasive routes which are not patient compliant and do not allow frequent administration. Intranasal delivery of therapeutics to target CSF and brain is a …
-
Quality of Life in Patients With Confirmed and Suspected Spinal CSF Leaks
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Experimental investigations of thermodynamic properties of the LiF –CsF binary system and FliNaK
… also identified. New measurements of the LiF –CsF system filled some knowledge gaps on the melting behaviour and revealed an additional phase that was not previously reported in the open literature.
-
CBL and CBL-B Dictate CSF-1R Endocytic Traffic and Signaling in Macrophages
<p>Macrophage colony stimulating factor receptor (CSF-1R or MCSFR) is a receptor tyrosine kinase essential for the growth and function of macrophages. Understanding the mechanisms that regulate CSF-1R activation and deactivation will provide insights to clinical treatment of macrophage related …
-
Entwicklung von GM-CSF-produzierenden EBV-Vektoren für die Immuntherapie der B-CLL
… zu entwickeln, die das therapeutische Zytokin GM-CSF in Tumorzellen von B-CLL-Patienten (Chronische lymphatische Leukämie) exprimieren. Dabei entscheidend ist die Eigenschaft von EBV naive, wie auch reife und maligne B-Lymphozyten über den CD21-Rezeptor spezifisch zu infizieren. Als Grundlage …
-
Transcriptional regulation of the GM-CSF gene in T lymphocytes / Cameron Stuart Osborne.
Describes the investigation as to whether the mouse granulocyte-macrophage colony-stimulating factor and interleukin-3 genes are regulated in a similar manner as those of the human, focussing on regulation through an enhancer.
-
The role of the bone marrow niche and G-CSF in osteochondral repair
… agent granulocyte-colony stimulating factor (G-CSF). This cytokine has previously been shown to improve the repair of osteochondral tissues, however, the cellular mechanisms underlying this response are poorly described. This thesis investigates BMSC and HSPC interactions in bone and cartilage …
-
Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… granulocyte-colony stimulating factor (G-CSF) has shown promise in neonatal HI investigations by improving neuromotor function and reducing apoptosis in the brain. Furthermore, G-CSF is shown in the naïve rat to regulate hormones of the HPA axis. Therefore we hypothesized that G-CSF may …
-
Regulation of proto-oncogenes and immune system genes during CSF-1-induced macrophage differentiation
CSF-1-induced bone marrow-derived macrophage (BMDM) differentiating in vitro acquire both antigen presenting and tumoricidal capabilities. In order to understand the molecular origin of macrophage diversity transcriptional and post-transcriptional regulation of genes involved in affector and …
-
The utility of CSF PCR in central nervous system Varicella zoster infection in HIV
… database at Groote Schuur Hospital with positive CSF VZV PCR who were also HIV co-infected and whose folders were available for clinical review were reviewed. Clinical and biochemical data were collected. Patients were divided into two groups based an accepted case definition for TBM. Differences …
-
Association between CSF Biomarkers and Performance on Neuropsychological Test in Patients with Mild Cognitive Impairment
… tau (P-Tau) in cerebrospinal fluid (CSF). To increase prognostic specificity of MCI to AD, studies have linked findings in CSF to neuropsychological profiles in MCI. The aim of this research was to find out if there is an association between critical biomarkers, such as tau and Aβ42 …
-
Colony Stimulating Factor-1 Receptor (CSF-1R) Expression, Degradation, and Signaling in Lipid-Laden Macrophages
… growth factor colony stimulating factor-1 (CSF-1); however, understanding the changes in CSF-1 signaling and related pathways in foam cells remain poorly investigated. Lipid-laden macrophages were formed through exposure of murine bone marrow derived macrophages to 100 μg/ml acetylated LDL …
-
The Role of the Pituitary-Adrenal Axis in G-CSF Therapy after Neonatal Hypoxia-Ischemia
… granulocyte-colony stimulating factor (G-CSF) has shown promise in neonatal HI investigations by improving neuromotor function and reducing apoptosis in the brain. Furthermore, G-CSF is shown in the naïve rat to regulate hormones of the HPA axis. Therefore we hypothesized that G-CSF may in …
-
Progesterone Enhances Macrophage Colony-Stimulating Factor(M-CSF) Production in Human Endometrial Stromal Cells in vitro
本文データは平成22年度国立国会図書館の学位論文(博士)のデジタル化実施により作成された画像ファイルを基にpdf変換したものである
-
Investigating the effects of CSF-1R and PI3Kdelta inhibition on a breast cancer bone metastasis model
… by several of these factors, in particular CSF-1. Given the ability of PI3K signaling to promote osteoclast survival and activity in a CSF-1R dependent manner, we hypothesized that inhibition of CSF-1R or PI3K signaling with compounds GW2580 and ABT-869, and IC87114, respectively, would …
-
Continuous improvement CSF framework for assessing CI maturity in ISO and non-ISO certified construction contracting organizations
… is to determine the Critical Success Factors (CSFs) for Continuous Improvement (CI) as a focused independent management tool in the Planning and Scheduling (P&S) of construction projects. 38 Success Factors of CI for P&S of construction projects from literature review were listed and verified …
-
Describing the immune cell profile of ventricular cerebrospinal fluid (CSF) in paediatric central nervous system (CNS) infections
… of infected ventricular cerebrospinal fluid (CSF), but there is often a paucity of cells in CSF samples, especially in conditions like tuberculous meningitis (TBM), and these undergo rapid immune cell death after sampling. Consequently, the cell populations in CSF are not well described. …
Page 1 of 21